西罗莫司缓释片的制备及其释药因素考察
Preparation of sirolimus sustained-release tables and observe of influence factors on releasing drug
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摘要: 目的: 制备西罗莫司缓释片并对其释药因素进行考察。 方法: 采用羟丙基甲基纤维素(HPMC)为基本骨架材料制备了西罗莫司凝胶骨架片,对影响释药的因素,如采用羟丙基甲基纤维素(HPMC)规格、用量、填充剂种类、致孔剂用量、压片压力及释放介质等进行了考察。 结果: 以30%羟丙基甲基纤维素(HPMC K4M)为骨架材料、2%乳糖为致孔剂、微晶纤维素(MCC)为填充剂时,缓释片呈明显一级释放特征。 结论: 该制剂在体外具有良好的缓释效果,且制备工艺简单易行。
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关键词:
- 西罗莫司 /
- 凝胶骨架缓释片 /
- 体外释放 /
- 羟丙基甲基纤维素(HPMC)
Abstract: Objective To prepare the sirolimus sustained-release tablets and study the influence factor. Methods The sirolimus sustained-release tablets were prepared by HPMC as the matrix material.The effects of viscosity of HPMC,sort of an adhensive amount of a lubricant,and the preparation Methods on the release of sirolimus from matrix tablets were observed. Results Based on the Results of single factor tests,an optimal self-prepared matrix sustsained-release tablets which contained 30 % HPMC(K4M),2 % lactose and MCC was definited.The release of the drug was an obvious characteristic in first class. Conclusion The tables have desirable sustain-release property in vitro.The preparation process was simple and can be applied in production.-
Key words:
- sirolimus /
- matrix sustained-release tablets /
- drug release in vitro /
- HPMC
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