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烟酰胺磷酸核糖转移酶的调控因素及药物作用

吕小群 张偌瑜 缪朝玉

吕小群, 张偌瑜, 缪朝玉. 烟酰胺磷酸核糖转移酶的调控因素及药物作用[J]. 药学实践与服务, 2011, 29(1): 11-14.
引用本文: 吕小群, 张偌瑜, 缪朝玉. 烟酰胺磷酸核糖转移酶的调控因素及药物作用[J]. 药学实践与服务, 2011, 29(1): 11-14.
LV Xiao-Qun, ZHANG Ruo-Yu, MIAO Chao-Yu. The regulatory factors and drug effects of nicotinamide phosphoribosyl transferase[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 11-14.
Citation: LV Xiao-Qun, ZHANG Ruo-Yu, MIAO Chao-Yu. The regulatory factors and drug effects of nicotinamide phosphoribosyl transferase[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 11-14.

烟酰胺磷酸核糖转移酶的调控因素及药物作用

基金项目: 国家973计划课题(2009CB521902);国家"重大新药创制"科技专项(2009ZX09303-002) ;上海市优秀学科带头人计划(10XD1405300);上海市血管生物学重点实验室开放课题基金(GXY2009001001).

The regulatory factors and drug effects of nicotinamide phosphoribosyl transferase

  • 摘要: 烟酰胺磷酸核糖转移酶(Nampt)是生命过程中不可或缺的蛋白,具有多种生理功能,对许多疾病如心脑血管疾病、糖尿病、癌症、自身免疫性疾病等有潜在的作用。阐明各种生理、病理状态以及化合物对Nampt表达水平的改变,可为Nampt的基础性和应用性研究起到推动作用。本文就各种因素对Nampt转录、表达调控的研究进展进行了较为系统的综述。
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    [2] Revollo JR, Korner A, Mills KF, et al. Nampt/PBEF/visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme[J]. Cell Metabolism, 2007, 6(5):363.
    [3] Van der VE, Ho C, O'Neil C, et al. Extension of human cell lifespan by nicotinamide phosphoribosyltransferase[J]. Journal of Biological Chemistry, 2007, 282(15):10841.
    [4] Yang HY, Yang T, Baur JA, et al. Nutrient-sensitive mitochondrial NAD(+) levels dictate cell survival[J]. Cell, 2007, 130(6):1095.
    [5] Kendal CE, Bryant-Greenwood GD. Pre-B-cell colony-enhancing factor (PBEF/visfatin) gene expression is modulated by NF-kB and AP-1 in human amniotic epithelial cells[J]. Placenta, 2007, 28(4):305.
    [6] Luk T, Malam Z, Marshall JC. Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity[J]. J Leukoc Biol, 2008, 83(4):804.
    [7] Wang T, Zhang X, Bheda P, et al. Structure of nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme[J]. Nat Struct Mol Biol, 2006, 13(7):661.
    [8] Frydelund-Larsen L, Akerstrom T, Nielsen S, et al. Visfatin mRNA expression in human subcutaneous adipose tissue is regulated by exercise[J]. Am J Physiol Endocrinol Metab, 2007, 292(1):E24.
    [9] Pilz S, Mangge H, Obermayer-Pietsch B, et al. Visfatin/pre-B-cell colony-enhancing factor:a protein with various suggested functions[J]. J Endocrinol Invest, 2007, 30(2):138.
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    [12] Sun G, Bishop J, Khalili S, et al. Serum visfatin concentrations are positively correlated with serum triacylglycerols and down-regulated by overfeeding in healthy young men[J]. Am J Clin Nutr, 2007, 85(2):399.
    [13] Pagano C, Pilon C, Olivieri M, et al. Reduced plasma visfatin/pre-B cell colony-enhancing factor in obesity is not related to insulin resistance in humans[J]. J Clin EndocrinolMetab,2006, 91(8):3165.
    [14] Botella-Carretero JI, Luque-Ramirez M, lvarez-Blasco F, et al. The increase in serum visfatin after bariatric surgery in morbidly obese women is modulated by weight loss, waist circumference, and presence or absence of diabetes before surgery[J]. Obes Surg, 2008, 18(8):1000.
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    [17] Unluturk U, Harmanci A, Yildiz BO, et al. Dynamics of nampt/visfatin and high molecular weight adiponectin in response to oral glucose load in obese and lean women[J]. Clin Endocrinol (Oxf),2009.
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    [21] Nakajima TE, Yamada Y, Hamano T, et al. Adipocytokine levels in gastric cancer patients: resistin and visfatin as biomarkers of gastric cancer[J]. J Gastroenterol, 2009, 44(7):685.
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    [25] Bauer L, Venz S, Junker H, et al. Nicotinamide phosphoribosyltransferase and prostaglandin H2 synthase 2 are up-regulated in human pancreatic adenocarcinoma cells after stimulation with interleukin-1[J]. Int J Oncol, 2009, 35(1):97.
    [26] Kralisch S, Klein J, Lossner U, et al. Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes[J]. J Endocrinol, 2005, 185(3):R1.
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    [28] MacLaren R, Cui W, Cianflone K. Visfatin expression is hormonally regulated by metabolicand sex hormones in 3T3-L1 pre-adipocytes and adipocytes[J]. Diabetes Obes Metab, 2007, 9(4):490.
    [29] Zhou H, Yang X, Wang NL, et al. Macrostemonoside A promotes visfatin expression in 3T3-L1 cells[J]. Biol Pharm Bull,2007,30(2):279.
    [30] Mukherjee S, Lekli I, Gurusamy N, et al. Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol[J]. Free Radic Biol Med, 2009, 46(5):573.
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  • 收稿日期:  2010-04-20
  • 修回日期:  2010-05-10

烟酰胺磷酸核糖转移酶的调控因素及药物作用

    基金项目:  国家973计划课题(2009CB521902);国家"重大新药创制"科技专项(2009ZX09303-002) ;上海市优秀学科带头人计划(10XD1405300);上海市血管生物学重点实验室开放课题基金(GXY2009001001).

摘要: 烟酰胺磷酸核糖转移酶(Nampt)是生命过程中不可或缺的蛋白,具有多种生理功能,对许多疾病如心脑血管疾病、糖尿病、癌症、自身免疫性疾病等有潜在的作用。阐明各种生理、病理状态以及化合物对Nampt表达水平的改变,可为Nampt的基础性和应用性研究起到推动作用。本文就各种因素对Nampt转录、表达调控的研究进展进行了较为系统的综述。

English Abstract

吕小群, 张偌瑜, 缪朝玉. 烟酰胺磷酸核糖转移酶的调控因素及药物作用[J]. 药学实践与服务, 2011, 29(1): 11-14.
引用本文: 吕小群, 张偌瑜, 缪朝玉. 烟酰胺磷酸核糖转移酶的调控因素及药物作用[J]. 药学实践与服务, 2011, 29(1): 11-14.
LV Xiao-Qun, ZHANG Ruo-Yu, MIAO Chao-Yu. The regulatory factors and drug effects of nicotinamide phosphoribosyl transferase[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 11-14.
Citation: LV Xiao-Qun, ZHANG Ruo-Yu, MIAO Chao-Yu. The regulatory factors and drug effects of nicotinamide phosphoribosyl transferase[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 11-14.
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