异槲皮苷抗抑郁作用实验研究
Experimental study on the antidepressant activities of Isoquercitrin
-
摘要: 目的 研究异槲皮苷对抑郁症模型小鼠的的抗抑郁活性。 方法 ICR小鼠,随机分为空白模型组、阳性对照(盐酸氟西汀)组、异槲皮苷不同剂量组和10%异槲皮苷混合物不同剂量组,观察异槲皮苷对小鼠强迫游泳实验和小鼠悬尾实验的影响。 结果 与模型组相比,0.3 mg/kg槲皮苷和3 mg/kg10%异槲皮苷混合物能显著缩短小鼠在绝望模型中的不动时间(P<0.01)。 结论 低剂量的异槲皮苷具有一定的抗抑郁活性,其机制可能与异槲皮苷的抗氧化作用及抑制皮质激素分泌有关。Abstract: Objective To study the antidepressant activities of Isoquercitrin on desperate rats model. Methods ICR Mice were randomly divided into control group,fluoxetine hydrochloride group , Isoquercitrin and Isoquercitrin mixture of different dose groups.The Frost Swimming Test (FST) and the Tail Suspension Test (TST) in mice were applied to evaluate antidepressant activitie. Results Compared with the control group, low dosages(0.3 mg/kg, 3mg/kg) of Isoquercitrin and 10% Isoquercitrin mixture had significantly reduced the immobility time in the behavior tests(P<0.01). Conclusions Low dosage of Isoquercitrin showed some antidepressant activities, which was related to antioxidative effect and inhibiting of adrenocortical hormones.
-
Key words:
- Isoquercitrin /
- antidepressant /
- the Forced Swimming Test /
- the Tail Suspension Test
-
[1] Steimer W. Pharmacogenetics and Psychoactive Drug Therapy: Ready for the Patient[J]. Ther Drug Monit. 2010, Aug;32(4):381. [2] Xu C, Luo L, Tan RX. Antidepressant effect of three traditional Chinese medicines in the learned helplessness model[J]. Journal of Ethnopharmacology 2004, 91: 345. [3] Zhang ZJ. Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders[J]. Life Sciences 2004, 75:1659. [4] 俞一心,戈升荣,王桂珍. 槲皮素及其衍生物的药理作用研究进展[J].中药材,2003, 26(12): 902. [5] 徐书云,卞如濂,陈 修,等. 药理实验方法学[M].第3版.北京:人民卫生出版社,2002:226. [6] Doe N, Takahashi T, Kiriyama M. Behavioral despair during a water maze learning task in mice[J]. Exp Anim, 2010, 59(2):191. [7] Jang DP, Lee SH, Lee SY, et al. Neural responses of rats in the forced swimming test: [F-18]FDG micro PET study[J]. Behav Brain Res, 2009, 203(1):43. [8] Butterweck V, Jürgenliemk G, Nahrstedt A,et al. Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test[J]. Planta Medica 2000, 66:3. [9] Butterweck V, Hegger M, Winterhoff H. Flavonoids of St. John's Wort reduce HPA axis function in the rat[J]. Planta Med,2004,70(10):1008. [10] 黄黎明, 石 鹏, 孙成荣等. 柴芪口服液抗抑郁作用实验研究[J]. 中国药师, 2009,12(1): 44. -
点击查看大图
计量
- 文章访问数: 2663
- HTML全文浏览量: 212
- PDF下载量: 372
- 被引次数: 0
下载:
