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线粒体靶向抗氧化剂研究进展

樊鹏程,  葛越,  蒋炜,  景临林,  马慧萍,  贾正平

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文章导航 > 药学实践与服务  > 2015 >  33(1): 1-4,8
樊鹏程, 葛越, 蒋炜, 景临林, 马慧萍, 贾正平. 线粒体靶向抗氧化剂研究进展[J]. 药学实践与服务, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001
引用本文: 樊鹏程, 葛越, 蒋炜, 景临林, 马慧萍, 贾正平. 线粒体靶向抗氧化剂研究进展[J]. 药学实践与服务, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001
shu
FAN Pengcheng, GE Yue, Jiang Wei, JING Linlin, MA Huiping, JIA Zhengping. Research progress in mitochondria-targeted antioxidants[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001
Citation: FAN Pengcheng, GE Yue, Jiang Wei, JING Linlin, MA Huiping, JIA Zhengping. Research progress in mitochondria-targeted antioxidants[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001
shu

线粒体靶向抗氧化剂研究进展

doi: 10.3969/j.issn.1006-0111.2015.01.001
  • 1.

    兰州军区兰州总医院药剂科, 甘肃 兰州 730050;全军高原环境损伤防治研究重点实验室, 甘肃 兰州 730050

  • 2.

    延安市宝塔区妇幼保健院, 陕西 延安 716000

基金项目: 国家自然科学基金资助项目(81202458);全军医药卫生科研项目(CLZ12JB06)

Research progress in mitochondria-targeted antioxidants

  • 1.

    Department of Pharmacy, Lanzhou General Hospital of Lanzhou Region, Lanzhou 730050, China;Key Laboratory of Entire Army Plateau Environment Injury Prevention Research, Lanzhou 730050, China

  • 2.

    Meternal and Child Health Care of Baota District, Yan'an 716000, China

  • 摘要: 线粒体是细胞呼吸的主要场所,在细胞的生命周期中扮演重要角色,三羧酸循环和氧化磷酸化都是在线粒体中进行。线粒体功能障碍可导致一系列疾病,如缺血-再灌注损伤、败血症和糖尿病等。线粒体是神经退行性病变的治疗靶点,也是药物转运策略研究的引人注目的靶位。虽然线粒体所介导的疾病进程的分子机制尚未完全阐明,但氧化应激是关键的环节。开发线粒体靶向的抗氧化应激保护药物具有诱人的前景。线粒体靶向抗氧化剂是指以线粒体为作用靶位的具有抗氧化作用的药物。该文介绍了现有的线粒体靶向抗氧化剂的概念、分类及其疾病治疗研究进展。
    Abstract: Mitochondria are the main places of cellular respiration as well as the citric acid cycle and oxidative phosphorylation.It plays an important role in controlling the life and death of cells.Mitochondrial dysfunction leads to a series of human diseases such as ischemia-reperfusion injury,sepsis and diabetes.Mitochondrial become an attractive target for drug transporters strategy and therapeutic targets for neurodegeneration.Although the molecular mechanisms responsible for mitochondria mediated disease processes are not fully elucidated yet,the oxidative stress appears to be critical.Accordingly,strategies are being developed for the targeted delivery of antioxidants to mitochondria.The prospect of development of mitochondrial targeted drugs with anti-oxidative stress protection is tempting.Mitochondrial targeting antioxidants were the antioxidant drugs which took mitochondria as the target site.In this review,weintroduced the conception and classification of mitochondrial targeted antioxidants and the research progress of disease treatment by mitochondrial targeted antioxidants.
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  • 收稿日期:  2013-11-28
  • 修回日期:  2014-03-26

线粒体靶向抗氧化剂研究进展

doi: 10.3969/j.issn.1006-0111.2015.01.001
  • 1. 兰州军区兰州总医院药剂科, 甘肃 兰州 730050;全军高原环境损伤防治研究重点实验室, 甘肃 兰州 730050
  • 2. 延安市宝塔区妇幼保健院, 陕西 延安 716000
    • 基金项目:  国家自然科学基金资助项目(81202458);全军医药卫生科研项目(CLZ12JB06)
  • 收稿日期: 2013-11-28
  • 修回日期: 2014-03-26

摘要: 线粒体是细胞呼吸的主要场所,在细胞的生命周期中扮演重要角色,三羧酸循环和氧化磷酸化都是在线粒体中进行。线粒体功能障碍可导致一系列疾病,如缺血-再灌注损伤、败血症和糖尿病等。线粒体是神经退行性病变的治疗靶点,也是药物转运策略研究的引人注目的靶位。虽然线粒体所介导的疾病进程的分子机制尚未完全阐明,但氧化应激是关键的环节。开发线粒体靶向的抗氧化应激保护药物具有诱人的前景。线粒体靶向抗氧化剂是指以线粒体为作用靶位的具有抗氧化作用的药物。该文介绍了现有的线粒体靶向抗氧化剂的概念、分类及其疾病治疗研究进展。

English Abstract

樊鹏程, 葛越, 蒋炜, 景临林, 马慧萍, 贾正平. 线粒体靶向抗氧化剂研究进展[J]. 药学实践与服务, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001
引用本文: 樊鹏程, 葛越, 蒋炜, 景临林, 马慧萍, 贾正平. 线粒体靶向抗氧化剂研究进展[J]. 药学实践与服务, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001
shu
FAN Pengcheng, GE Yue, Jiang Wei, JING Linlin, MA Huiping, JIA Zhengping. Research progress in mitochondria-targeted antioxidants[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001
Citation: FAN Pengcheng, GE Yue, Jiang Wei, JING Linlin, MA Huiping, JIA Zhengping. Research progress in mitochondria-targeted antioxidants[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001
shu

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