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长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展

丁佳宁,  马进原,  朱全刚

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文章导航 > 药学实践与服务  > 2019 >  37(5): 390-393,421
丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
引用本文: 丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
shu
DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
Citation: DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
shu

长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展

doi: 10.3969/j.issn.1006-0111.2019.05.002
  • 1.

    上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437

  • 2.

    上海市皮肤病医院药剂科, 上海 200443

  • 3.

    上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437;上海市皮肤病医院药剂科, 上海 200443

基金项目: 国家自然科学基金（81472394）；上海市皮肤病医院国家自然科学基金培育项目（17GZRPY11）

Research progress of lncRNA MEG3 in tumorigenesis

  • 1.

    Department of Pharmacy Laboratory, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China

  • 2.

    Department of Pharmacy, Shanghai Dermatology Hospital, Shanghai 200443, China

  • 3.

    Department of Pharmacy Laboratory, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;Department of Pharmacy, Shanghai Dermatology Hospital, Shanghai 200443, China

  • 摘要: 长链非编码RNA（long non-coding RNA，lncRNA）覆盖了人类DNA的大部分非编码信息，占整个基因组的90%以上，它们构成了一个广泛而复杂的分子群，在肿瘤的病理生理过程中以多种形式存在。2003年，lncRNA人母系表达基因（MEG）3被证明是垂体瘤的一个潜在的肿瘤抑制因子，之后研究者又在脑膜瘤、肝癌、肺癌、神经内分泌瘤，以及前列腺癌等其他肿瘤上对其在基因表达调控、印记、转录和翻译后的作用上进行了研究，发现MEG3在多种恶性肿瘤组织中低表达或表达缺失，而上调MEG3的表达与肿瘤生长抑制相关，其在肿瘤发生中的作用和机制得到了更好地阐明。总结MEG3的功能及在肿瘤发生中的研究进展。
    Abstract: Long non-coding RNA (lncRNA) covers most of the messages from the human DNA without protein-coding potential,which is a wide range of complicated molecules that consist of more than 90% of the whole genomic and present in different forms in the course of pathophysiology of cancers.In 2003,lncRNA MEG3 was firstly discovered as a potential tumor-inhibiting factor of pituitary adenomas.Later on,the roles and mechanisms in the regulation of gene expression,imprinting,transcription,and post-translation of MEG3 in meningioma,hepatocellular cancer,lung cancer,neuroendocrine tumor,prostate cancer and other kinds of tumors were further clarified,indicated that the expression of MEG3 was down-regulated or deficient in a wide range of tumors while the expression up-regulation of MEG was greatly correlated with tumor inhibition.The function of MEG3 and its research progress in tumorigenesis were summarized in this paper.
  • [1] SANCHEZ CALLE A,KAWAMURA Y,YAMAMOTO Y,et al.Emerging roles of long non-coding RNA in cancer[J].Cancer Sci,2018,109(7):2093-2100.
    [2] KUMAR M M,GOYAL R.LncRNA as a therapeutic target for angiogenesis[J].Curr Top Med Chem,2017,17(15):1750-1757.
    [3] WEIDLE U H,BIRZELE F,KOLLMORGEN G,et al.Long non-coding RNAs and their role in metastasis[J].CGP,2017,14(3):143-160.
    [4] PALMIERI G,PALIOGIANNIS P,SINI M C,et al.Long non-coding RNA CASC2 in human cancer[J].Crit Rev Oncol Hematol,2017,111:31-38.
    [5] BRANNAN C I,DEES E C,INGRAM R S,et al.The product of the H19 gene may function as an RNA[J].Mol Cell Biol,1990,10(1):28-36.
    [6] LI T W,MO X Y,FU L Y,et al.Molecular mechanisms of long noncoding RNAs on gastric cancer[J].Oncotarget,2016,7(8):8601-8612.
    [7] WALLACE C,SMYTH D J,MAISURIA-ARMER M,et al.The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes[J].Nat Genet,2010,42(1):68-71.
    [8] SALLAM T,SANDHU J,TONTONOZ P.Long noncoding RNA discovery in cardiovascular disease:decoding form to function[J].Circ Res,2018,122(1):155-166.
    [9] FENG L,LIAO Y T,HE J C,et al.Plasma long non-coding RNA BACE1 as a novel biomarker for diagnosis of Alzheimer disease[J].BMC Neurol,2018,18(1):4.
    [10] LI H,YU B Q,LI J F,et al.Characterization of differentially expressed genes involved in pathways associated with gastric cancer[J].PLoS One,2015,10(4):e0125013.
    [11] SONG H J,SUN W L,YE G L,et al.Long non——coding RNA expression profile in human gastric cancer and its clinical significances[J].J Transl Med,2013,11:225.
    [12] QIN Y,SUN W,ZHANG H,et al.LncRNA GAS8-AS1 inhibits cell proliferation through ATG5-mediated autophagy in papillary thyroid cancer[J].Endocrine,2018,59(3):555-564.
    [13] ZHANG L G,ZHOU X K,ZHOU R J,et al.Long non-coding RNA LINC00673 promotes hepatocellular carcinoma progression and metastasis through negatively regulating miR-205[J].Am J Cancer Res,2017,7(12):2536-2544.
    [14] ZHANG X,RICE K,WANG Y Y,et al.Maternally expressed gene 3(MEG3) noncoding ribonucleic acid:isoform structure,expression,and functions[J].Endocrinology,2010,151(3):939-947.
    [15] MIYOSHI N,WAGATSUMA H,WAKANA S,et al.Identification of an imprinted gene,Meg3/Gtl2 and its human homologue MEG3,first mapped on mouse distal chromosome 12 and human chromosome 14q[J].Genes Cells,2000,5(3):211-220.
    [16] ZHANG X,ZHOU Y L,MEHTA K R,et al.A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells[J].J Clin Endocrinol Metab,2003,88(11):5119-5126.
    [17] ZHAO J,ZHANG X,ZHOU Y L,et al.Cyclic AMP stimulates MEG3 gene expression in cells through a cAMP-response element (CRE) in the MEG3 proximal promoter region[J].Int J Biochem Cell Biol,2006,38(10):1808-1820.
    [18] ZHOU Y L,ZHONG Y,WANG Y Y,et al.Activation of p53 by MEG3 non-coding RNA[J].J Biol Chem,2007,282(34):24731-24742.
    [19] KRUER T L,DOUGHERTY S M,REYNOLDS L,et al.Expression of the lncRNA maternally expressed gene 3(MEG3) contributes to the control of lung cancer cell proliferation by the rb pathway[J].PLoS One,2016,11(11):e0166363.
    [20] GORDON F E,NUTT C L,CHEUNSUCHON P,et al.Increased expression of angiogenic genes in the brains of mouse meg3-null embryos[J].Endocrinology,2010,151(6):2443-2452.
    [21] BENETATOS L,VARTHOLOMATOS G,HATZIMICHAEL E.MEG3 imprinted gene contribution in tumorigenesis[J].Int J Cancer,2011,129(4):773-779.
    [22] BOUCKENHEIMER J,ASSOU S,RIQUIER S,et al.Long non-coding RNAs in human early embryonic development and their potential in ART[J].Hum Reprod Update,2016,23(1):19-40.
    [23] CHEUNSUCHON P,ZHOU Y L,ZHANG X,et al.Silencing of the imprinted DLK1-MEG3 locus in human clinically nonfunctioning pituitary adenomas[J].Am J Pathol,2011,179(4):2120-2130.
    [24] CHUNHAROJRITH P,NAKAYAMA Y,JIANG X B,et al.Tumor suppression by MEG3 lncRNA in a human pituitary tumor derived cell line[J].Mol Cell Endocrinol,2015,416:27-35.
    [25] ZHANG X,GEJMAN R,MAHTA A,et al.Maternally expressed gene 3,an imprinted noncoding RNA gene,is associated with meningioma pathogenesis and progression[J].Cancer Res,2010,70(6):2350-2358.
    [26] BRACONI C,KOGURE T,VALERI N,et al.MicroRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer[J].Oncogene,2011,30(47):4750-4756.
    [27] MODALI S D,PAREKH V I,KEBEBEW E,et al.Epigenetic regulation of the lncRNA MEG3 and its target c-MET in pancreatic neuroendocrine tumors[J].Mol Endocrinol,2015,29(2):224-237.
    [28] LU K H,LI W,LIU X H,et al.Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression[J].BMC Cancer,2013,13:461.
    [29] RIBARSKA T,BASTIAN K M,KOCH A,et al.Specific changes in the expression of imprinted genes in prostate cancer:implications for cancer progression and epigenetic regulation[J].Asian J Androl,2012,14(3):436-450.
    [30] RIBARSKA T,GOERING W,DROOP J,et al.Deregulation of an imprinted gene network in prostate cancer[J].Epigenetics,2014,9(5):704-717.
    [31] LUO G,WANG M,WU X,et al.Long non-coding RNA MEG3 inhibits cell proliferation and induces apoptosis in prostate cancer[J].Cell Physiol Biochem,2015,37(6):2209-2220.
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长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展

doi: 10.3969/j.issn.1006-0111.2019.05.002
  • 1. 上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437
  • 2. 上海市皮肤病医院药剂科, 上海 200443
  • 3. 上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437;上海市皮肤病医院药剂科, 上海 200443
    • 基金项目:  国家自然科学基金（81472394）；上海市皮肤病医院国家自然科学基金培育项目（17GZRPY11）
  • 收稿日期: 2019-04-04
  • 修回日期: 2019-06-11

摘要: 长链非编码RNA（long non-coding RNA，lncRNA）覆盖了人类DNA的大部分非编码信息，占整个基因组的90%以上，它们构成了一个广泛而复杂的分子群，在肿瘤的病理生理过程中以多种形式存在。2003年，lncRNA人母系表达基因（MEG）3被证明是垂体瘤的一个潜在的肿瘤抑制因子，之后研究者又在脑膜瘤、肝癌、肺癌、神经内分泌瘤，以及前列腺癌等其他肿瘤上对其在基因表达调控、印记、转录和翻译后的作用上进行了研究，发现MEG3在多种恶性肿瘤组织中低表达或表达缺失，而上调MEG3的表达与肿瘤生长抑制相关，其在肿瘤发生中的作用和机制得到了更好地阐明。总结MEG3的功能及在肿瘤发生中的研究进展。

English Abstract

丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
引用本文: 丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
shu
DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
Citation: DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
shu

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