7-氮杂吲哚-3-羧酸的合成工艺改进
Improvement of the synthetic process of 7-azaindol-3-carboxylic acid
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摘要: 目的:改进7-氮杂吲哚-3-羧酸的合成工艺。方法:以丁二腈为起始原料,用四氢呋喃、乙酸乙酯、石油醚等代替了原工艺中的异丙醚,正庚烷,氯苯等,并对处理工艺进行了优化。结果:优化后的制备工艺成本低,毒性小,后处理方便,提高了产率。结论:新工艺总产率达到43.4%,更适合工业生产。
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关键词:
- 7-氮杂吲哚-3-羧酸 /
- 合成 /
- 工艺改进
Abstract: Objective : To improve the synthetic process of 7-azaindol-3-carboxylic acid. Methods : The succinonitrile was taken as the original raw material.The isopropyl ether,n-heptane,and chlorobenzene, which were used in original technics,were subsituted by ethyl acetate,petroleun ether,and xylene respectively.The disposition technics was optimized. Results : The technics was successfully improved due to its low cost,small toxicity,convenient disposition and high yield. Conclusions : The higher overall yields was 43.4%.This improved method is more suitable for industrial production for its low cost.-
Key words:
- 7-Azaindol-3-carboxylic acid /
- synthesis /
- technical improvement
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