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膜联蛋白A3 (ANXA3),又名1,2-环-肌醇-磷酸磷酸二酯酶、脂皮质素III、胎盘抗凝蛋白Ⅲ等,属于膜联蛋白家族的成员。研究发现,ANXA3可以将肌醇1,2-环磷酸盐水解为肌醇1-磷酸,也可以抑制磷脂酶A2(PLA2)的活性。截至目前,关于ANXA3基因和蛋白的结构、功能及相关疾病已有许多文献报道,本文主要就这些研究进展进行综述,为ANXA3进一步深入研究提供参考。
Research progress on ANXA3 gene and protein
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摘要: 膜联蛋白A3(ANXA3)属于膜联蛋白家族成员,具有36 kDa和33 kDa两个亚型,其基因位于人第四号染色体上。ANXA3在人体骨髓、肺脏、胎盘、前列腺和甲状腺等组织中表达,与胞吐、血管生成、脂肪细胞成熟和白细胞迁移等生物学过程密切相关。研究发现,ANXA3在癌症、心血管疾病和炎症等疾病中异常表达,可以调 控JNK、NF-κB、PI3K/Akt等多条信号通路,可能成为相关疾病的治疗靶点。本文主要就ANXA3的结构、功能、与疾病的联系以及相关机制进行综述,希望能够为ANXA3的相关研究提供借鉴。Abstract: Annexin A3(ANXA3)is a member of the membrane associated protein family. It has two subtypes of 36 kDa and 33 kDa. Its gene is located on the fourth chromosome of human. ANXA3, widely expressed in human bone marrow, lung, placenta, prostate and thyroid, is closely related to several biological processes such as exoplasmosis, vascular production, fat cell maturity, and white blood cell migration. Studies have found that ANXA3 is abnormally expressed in various diseases including cancer, cardiovascular disease and inflammation. It can regulate multiple signaling pathways such as JNK, NF-κB, PI3K/AKT, and may become a potential drug target for treatment of related diseases. The structure, functions, the link with diseases and related mechanisms of ANXA3 were summarized in this paper, which could provide reference for ANXA3 related research.
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Key words:
- Annexin A3 /
- structural function /
- disease mechanism
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