1-丁基-3-甲基咪唑-L-樟脑磺酸盐催化合成monastrol
Synthesis of monastrol catalyzed by 1-butyl-3-methylimidazolium (L)-camphorsulfonate
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摘要: 目的 探索环境友好、操作简便的monastrol合成方法。 方法 以间羟基苯甲醛、乙酰乙酸乙酯和硫脲为起始原料,在无溶剂微波加热条件下,用绿色室温离子液体1-丁基-3-甲基咪唑-L-樟脑磺酸盐催化Biginelli反应合成monastrol。 结果 1-丁基-3-甲基咪唑-L-樟脑磺酸盐在无溶剂微波加热条件下可催化Biginelli反应合成monastrol,操作简单、耗时缩短、环境友好。 结论 以新型绿色室温离子液体1-丁基-3-甲基咪唑-L-樟脑磺酸盐为催化剂,经微波促进无溶剂Biginelli反应合成monastrol是一种操作简便、反应温和的绿色合成方法。
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关键词:
- 绿色室温离子液体 /
- Monastrol /
- Biginelli反应 /
- 1-丁基-3-甲基咪唑-L-樟脑磺酸盐 /
- 微波
Abstract: Objective To explore a convenient and environmentally friendly benign synthesis method of monastrol. Methods Monastrol was synthesized from m-hydroxybenzaldehyde, ethyl acetoacetate and thiourea through the Biginelli reaction catalyzed by 1-butyl-3-methylimidazolium (L)-camphorsulfonate under microwave irradiation without a solvent. Results The green room temperature ionic liquid could catalyze the Biginelli reaction to get monsatrol under microwave irradiation without a solvent. The process was easy to operate and was environmentally friendly. Conclusion Microwave accelerated solvent-free Biginelli reaction using 1-butyl-3-methylimidazolium (L)-camphorsulfonate as catalyst, which was a convenient and environmentally benign synthesis method of monastrol. -
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