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艰难梭菌是一种革兰阳性厌氧芽孢杆菌,通过粪-口途径传播,艰难梭菌感染会引起腹泻,严重感染可导致伪膜性结肠炎、中毒性巨结肠、肠坏死,甚至危及生命[1-2]。
近年来艰难梭菌感染的发病率、复发率和病死率明显增加,已成为全球性的健康威胁[3]。美国艰难梭菌引起的医院感染为12.1%[4]。中国住院腹泻患者艰难梭菌感染发生率高达19%[5],大型医院住院腹泻患者艰难梭菌感染的检出率为11%~22%[6]。妊娠期若发生艰难梭菌感染,治疗方案需兼顾母儿安全。
现报道1例成功救治妊娠患者感染艰难梭菌的病例,临床药师参与了该患者药物治疗的全过程,协助医生制订用药方案,提供药物选择、注意事项等建议,并对特殊群体的用药安全性进行药学监护,得到临床医护人员、患者和家属的认可。
Clinical pharmacist participation in the treatment of a pregnancy complicated with Clostridium difficile infection
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摘要:
目的 探讨临床药师参与妊娠合并肠道艰难梭菌感染患者的药学实践重点和模式,保障母儿安全。 方法 临床药师从药物角度切入,严格按照循证医学证据将药学理论与临床实践相结合,为药物选择、剂量调整、保肝治疗等方面提供全程药学监护,协助医生制定用药方案,积极参与个体化治疗。 结果 临床药师融入治疗团队,保障了妊娠期患者用药的有效性和安全性。 结论 临床药师的个体化药学服务提高了药物治疗水平。 Abstract:Objective To explore the clinical pharmacist participation in the treatment of pregnancy complicated with Clostridium difficile infection. Methods From the perspective of medications, clinical pharmacists followed evidence-based medical practice, combined pharmaceutical theory with clinical evidence and provided individualized pharmacy care in drug selection, dose adjustment, medication regime and liver protection treatment. Results Clinical pharmacists integrated into the treatment team to ensure the effectiveness and safety of medication in the patient with pregnancy. Conclusion The individualized pharmacy care improved the effectiveness of drug treatment. -
Key words:
- clinical pharmacist /
- pregnancy /
- Clostridium difficile /
- pharmaceutical practice
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