2001 Vol. 19, No. 4
Display Method:
2001, (4): 202-203.
Abstract:
OBJECTIVE To develop the gel of sulfur and observe the clinical effect of the gel.METHODS The gel of sulfur was prepared by Carbopol-Ⅰ as the gel stroma,and the method of quality control was built up.52 cases with scabies were treated by the gel of sulfur while 40 cases were treated by the ointment of sulfur as control group.RESULTS The produce of the gel was easy and the stability was good.No side-effect was found in the gel group.CONCLUSIONS The gel is suitable to the clinical need,it is worthy to develop in clinic.
OBJECTIVE To develop the gel of sulfur and observe the clinical effect of the gel.METHODS The gel of sulfur was prepared by Carbopol-Ⅰ as the gel stroma,and the method of quality control was built up.52 cases with scabies were treated by the gel of sulfur while 40 cases were treated by the ointment of sulfur as control group.RESULTS The produce of the gel was easy and the stability was good.No side-effect was found in the gel group.CONCLUSIONS The gel is suitable to the clinical need,it is worthy to develop in clinic.
2001, (4): 206-208,205.
Abstract:
OBJECTIVE To investigate the protective effects of preconditioning on cardiac and pulmonary injury induced by lower extremity ischaemia-reperfusion in rats METHODS Animals were randomized into 4 groups and underwent laparotomy The abdominal aorta was isolated and clamped below the renal artery level for 120min then declamped for another 120min Group Ⅰ(n=8)was taken as control Group Ⅱ(n=8) was pretreatedwith ischaemia preconditioning that the lower extremities had experienced 4 times of ischaemia and reperfusion 5 min each before the 240 min treatment began Group Ⅲ(n=8) accepted continuous drip infusion of adenosine Group Ⅳ(n=8)was sham operated All groups were given Evan's blue dye intravenously after anesthesia Mean artery pressure(MAP), myocardium ATPase activities and malonyldiadehyde(MDA), pulmonary MDA and Evan's blue were determined separately. RESULTS MAP was lower in groupⅠand Ⅲ than in Ⅱ and Ⅳ,neither group Ⅰand Ⅲ, norⅡand Ⅳ, had significant differences(Ⅰ:61±14;Ⅱ:86±12; Ⅲ:69±18;Ⅳ:94±23mmHg) Myocardium ATPase activity was lower in group Ⅰthan in group Ⅱ,Ⅲ,Ⅳ(Na+ K+ ATPase 8.1±0.4 vs 8.9±2.1, 9.4±1.0and 9.0±0.8U/mg; Ca2+ ATPase 5.0±0.2 vs 5.3±1.0, 5.9±0.7and 5 7±0 8U/mg; Mg2+ ATPase 4.4±0.3 vs 5.2±0.8, 5.1±0.71and 5.3±0.6 U/mg),the MDA level was higher in groupⅠthan in group Ⅱ,Ⅲ,Ⅳ(MDA 2.5±0.4 vs 1.8±0.7, 1.6±0.5 and 1.7±0.7nmol/mg) Pulmonary MDA and Evan's blue level were higher in group Ⅰthan in the other three groups(MDA 2.3±0.2vs 1.6±0.4, 1.8±0.5 and 1.4±0.6nmol/mg; Evan's blue 3.1±1.2 vs 1.6±0.5, 1.5±0.3and 0.9±0.2μg/mg) CONCLUSION Ischaemia and adenosine preconditioning have some protective effects on cardiac and pulmonary injury induced by ischaemia reperfusion of lower extremity in rats.
OBJECTIVE To investigate the protective effects of preconditioning on cardiac and pulmonary injury induced by lower extremity ischaemia-reperfusion in rats METHODS Animals were randomized into 4 groups and underwent laparotomy The abdominal aorta was isolated and clamped below the renal artery level for 120min then declamped for another 120min Group Ⅰ(n=8)was taken as control Group Ⅱ(n=8) was pretreatedwith ischaemia preconditioning that the lower extremities had experienced 4 times of ischaemia and reperfusion 5 min each before the 240 min treatment began Group Ⅲ(n=8) accepted continuous drip infusion of adenosine Group Ⅳ(n=8)was sham operated All groups were given Evan's blue dye intravenously after anesthesia Mean artery pressure(MAP), myocardium ATPase activities and malonyldiadehyde(MDA), pulmonary MDA and Evan's blue were determined separately. RESULTS MAP was lower in groupⅠand Ⅲ than in Ⅱ and Ⅳ,neither group Ⅰand Ⅲ, norⅡand Ⅳ, had significant differences(Ⅰ:61±14;Ⅱ:86±12; Ⅲ:69±18;Ⅳ:94±23mmHg) Myocardium ATPase activity was lower in group Ⅰthan in group Ⅱ,Ⅲ,Ⅳ(Na+ K+ ATPase 8.1±0.4 vs 8.9±2.1, 9.4±1.0and 9.0±0.8U/mg; Ca2+ ATPase 5.0±0.2 vs 5.3±1.0, 5.9±0.7and 5 7±0 8U/mg; Mg2+ ATPase 4.4±0.3 vs 5.2±0.8, 5.1±0.71and 5.3±0.6 U/mg),the MDA level was higher in groupⅠthan in group Ⅱ,Ⅲ,Ⅳ(MDA 2.5±0.4 vs 1.8±0.7, 1.6±0.5 and 1.7±0.7nmol/mg) Pulmonary MDA and Evan's blue level were higher in group Ⅰthan in the other three groups(MDA 2.3±0.2vs 1.6±0.4, 1.8±0.5 and 1.4±0.6nmol/mg; Evan's blue 3.1±1.2 vs 1.6±0.5, 1.5±0.3and 0.9±0.2μg/mg) CONCLUSION Ischaemia and adenosine preconditioning have some protective effects on cardiac and pulmonary injury induced by ischaemia reperfusion of lower extremity in rats.
2001, (4): 209-211.
Abstract:
OBJECTIVE To determine the techniqe and quality standards of Xuan-fei-zhi-ke syrup. METHODS Three techniques(decocting,decocting+ethanol precipitating,separate decocting+ethanol-precipitating) were adopted to prepare the syrup sample Ⅰ, Ⅱ,and Ⅲ respectively.The 3 samples were evaluated by qualitative and quantitative analysis.RESULTS The ephedrine and baicalin in sample Ⅲ were the highest among the 3 samples. CONCLUSION The separate decocting plus ethanol precipitating is the best preparation techniqe for Xuan-fei-zhi-ke syrup.The quality standards for Xuan-fei-zhi-ke syrup are that baicalin content must be more than 0.2mg/ml,and the qualitative analysis of ephedrine, flavonoids and saponins must be positive reaction.
OBJECTIVE To determine the techniqe and quality standards of Xuan-fei-zhi-ke syrup. METHODS Three techniques(decocting,decocting+ethanol precipitating,separate decocting+ethanol-precipitating) were adopted to prepare the syrup sample Ⅰ, Ⅱ,and Ⅲ respectively.The 3 samples were evaluated by qualitative and quantitative analysis.RESULTS The ephedrine and baicalin in sample Ⅲ were the highest among the 3 samples. CONCLUSION The separate decocting plus ethanol precipitating is the best preparation techniqe for Xuan-fei-zhi-ke syrup.The quality standards for Xuan-fei-zhi-ke syrup are that baicalin content must be more than 0.2mg/ml,and the qualitative analysis of ephedrine, flavonoids and saponins must be positive reaction.
2001, (4): 219-221.
Abstract:
OBJECTIVE To prepare lomefloxacin hydrochloride cream, and establish the quality control standard. METHODS The content of lomefloxacin hydrochloride was determined with ultraviolet spectrophotometry. The solvent was methyl alcohol,the wavelength of determination was 287nm.RESULTS The average rate of lomefloxacin hydrochloride was 99.80%,and its RSD was 0.27%(n=6).The base of lomefloxacin hydrochloride cream didn't disturb this determination. CONCLUSION The technological process of lomefloxacin hydrochloride cream is easy. The method of content determination is simple and accurate.
OBJECTIVE To prepare lomefloxacin hydrochloride cream, and establish the quality control standard. METHODS The content of lomefloxacin hydrochloride was determined with ultraviolet spectrophotometry. The solvent was methyl alcohol,the wavelength of determination was 287nm.RESULTS The average rate of lomefloxacin hydrochloride was 99.80%,and its RSD was 0.27%(n=6).The base of lomefloxacin hydrochloride cream didn't disturb this determination. CONCLUSION The technological process of lomefloxacin hydrochloride cream is easy. The method of content determination is simple and accurate.
2001, (4): 222-224.
Abstract:
OBJECTIVE To develop a new RP-HPLC method was established for the determination of content uniformity in levamlodipine besylate tablets with nicadipine as the internal standard by RP HPLC.METHODS The separation was performed on Hypersil ODS 2(200mm×40mmID,5μm)column with 0.02mol/L sodium dihydrogen phosphate acetonitrile triethylamine(60:40:0.05)as mobile phase.The detection wavelength was 238nm.RESULTS Levamlodipine and nicadipine were isolated within 6min.A good linearity was obtained in the range of 1.642～52.56μg/ml(r=0.9999,n=5)for levamlodipine besylate and the average recovery was 100.8% with the RSD of 0.85%.CONCLUSION The method is simple, rapid, accurate,reliable and suitable for the determination of content uniformity in levamlodipine besylate tablets.
OBJECTIVE To develop a new RP-HPLC method was established for the determination of content uniformity in levamlodipine besylate tablets with nicadipine as the internal standard by RP HPLC.METHODS The separation was performed on Hypersil ODS 2(200mm×40mmID,5μm)column with 0.02mol/L sodium dihydrogen phosphate acetonitrile triethylamine(60:40:0.05)as mobile phase.The detection wavelength was 238nm.RESULTS Levamlodipine and nicadipine were isolated within 6min.A good linearity was obtained in the range of 1.642～52.56μg/ml(r=0.9999,n=5)for levamlodipine besylate and the average recovery was 100.8% with the RSD of 0.85%.CONCLUSION The method is simple, rapid, accurate,reliable and suitable for the determination of content uniformity in levamlodipine besylate tablets.
2001, (4): 224-225.
Abstract:
OBJECTIVE To determine the content of baicalin in Xiaochaihu granules to provide evidence for medicine quality control.METHODS The content of baicalin was determined by HPTLCS with 279nm,as detection wavelength and with acetic ether acetone acetic acidwater(10:8:5:5) as developer.RESULTS The average content of baicalin was 0.48%,RSD=0.44%, the average recovery was 103.7%.CONSOLUTIOND This method is simple,rapid and accurate with good reproducibility.
OBJECTIVE To determine the content of baicalin in Xiaochaihu granules to provide evidence for medicine quality control.METHODS The content of baicalin was determined by HPTLCS with 279nm,as detection wavelength and with acetic ether acetone acetic acidwater(10:8:5:5) as developer.RESULTS The average content of baicalin was 0.48%,RSD=0.44%, the average recovery was 103.7%.CONSOLUTIOND This method is simple,rapid and accurate with good reproducibility.
2001, (4): 226-228.
Abstract:
OBJECTIVE To determine astragaloside IV in Hua hai yi gan granules.METHOD Dual wavelength TLC scanning was used.RESULTS The average recovery was 100.7% and RSD was 1.59%.CONCLUSION The method is available for quality control of Hua-hai-yi-gan granules.
OBJECTIVE To determine astragaloside IV in Hua hai yi gan granules.METHOD Dual wavelength TLC scanning was used.RESULTS The average recovery was 100.7% and RSD was 1.59%.CONCLUSION The method is available for quality control of Hua-hai-yi-gan granules.
2001, (4): 229-230.
Abstract:
OBJECTIVE To estabish a quantiative analysis for Jing fu ping liqour.METHODS Jing fu ping liquor was determined in 0.1mol/L HCl.The wavelength of detection were 417nm and 277nm.RESULTS There were good linear correlation in the range of erythromycin(5.0～20.0μg/ml) and metronidazolum(2.0～15.0μg/ml),the average recovery and relative standard deviation were 98.55% and 0.52%(n=5) for erythromycin 98.86% and 0.51%(n=5) for metronidazolum.CONCLUSIONS The method is simple,rapid and auurate.
OBJECTIVE To estabish a quantiative analysis for Jing fu ping liqour.METHODS Jing fu ping liquor was determined in 0.1mol/L HCl.The wavelength of detection were 417nm and 277nm.RESULTS There were good linear correlation in the range of erythromycin(5.0～20.0μg/ml) and metronidazolum(2.0～15.0μg/ml),the average recovery and relative standard deviation were 98.55% and 0.52%(n=5) for erythromycin 98.86% and 0.51%(n=5) for metronidazolum.CONCLUSIONS The method is simple,rapid and auurate.
2001, (4): 231-233.
Abstract:
OBJECTIVE Study on the physiological characteristics of Monascus fungi.METHODS Control as Aspergillus terreus ,the 7 ordinary species of Monascus including M.aurantiacus Lee,et al were tested with 9 kinds of sources of nitrogen and 13 kinds of sources of carbon and the abilities of hydrolysis of gelatin.RESULTS All of the tested Monascus can utilize organic nitrogen such as soybean flour,while exist obviously differences in using inorganic nitrogen such as ammonium sulfate.The tested Monascus can utilize most of carbohydrates,while not utilize lactobionic acid.There exist obviously differences in using gossypose,lactose,rhamnose and sorboae. M.serorubesceus Sato and M.purpureus Went can hydrolyze gelatin while others not.CONCLUSION There are valuable of nitrogen and carbon utilization and the abilities of hydrolyzing gelatin to the identification of Monascus fungi.
OBJECTIVE Study on the physiological characteristics of Monascus fungi.METHODS Control as Aspergillus terreus ,the 7 ordinary species of Monascus including M.aurantiacus Lee,et al were tested with 9 kinds of sources of nitrogen and 13 kinds of sources of carbon and the abilities of hydrolysis of gelatin.RESULTS All of the tested Monascus can utilize organic nitrogen such as soybean flour,while exist obviously differences in using inorganic nitrogen such as ammonium sulfate.The tested Monascus can utilize most of carbohydrates,while not utilize lactobionic acid.There exist obviously differences in using gossypose,lactose,rhamnose and sorboae. M.serorubesceus Sato and M.purpureus Went can hydrolyze gelatin while others not.CONCLUSION There are valuable of nitrogen and carbon utilization and the abilities of hydrolyzing gelatin to the identification of Monascus fungi.
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