利巴韦林片的处方优化
Prescription optimize of ribavirini tablets
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摘要: 目的 筛选利巴韦林片的最佳处方。方法 考察糊精、羧甲基淀粉钠、微晶纤维素和低取代羟丙基纤维素对利巴韦林片的质量影响。结果 所筛选的适宜润湿剂为 75%乙醇,L-HPC和微晶纤维素的最佳用量分别为 10%和 15%.按照最佳处方制备的利巴韦林片硬度和外观大为改善。结论 本法处方合理,工艺简单,所制备的利巴韦林片适合临床应用。Abstract: OBJECTIVE To obtain the optimum prescription of ribavirini tablets METHODS The effect of dextrin CMS-Na microcrystalline cellulose and L-HPC on the quality of ribavirini tablets were studied RESULTS The optimum mistening agents is 75% alcohol,and the optimum amount of L-HPC and micro-crystaline cellulose are 10% and 15% respectively Ribavirini tablets prepared with this optimum prescription was much better in terms of hardness and surfaces CONCLUSION The method is reasonable,and the ribavirini tablets were suitable for clinical use.
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Key words:
- ribavirin /
- tablet /
- prescription optimize
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