白英提取物镇痛抗炎作用的实验研究
Experimental study of anti-inflammatory and analgesic effects of extracts of Solanum lyratum thumb
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摘要: 目的:初步探讨中药白英提取物的镇痛抗炎作用。方法:取白英的水提取物和乙醇提取物,应用醋酸致小鼠扭体法、小鼠热板法研究是镇痛作用;应用二甲苯致小鼠耳廓肿胀法和大鼠角叉菜胶足跖肿胀法研究其镇痛抗炎作用。结果:白英水提取物和乙醇提取物可减少醋酸致小鼠扭体次数,延长小鼠舔足时间;减轻二甲苯致小鼠耳廓肿胀程度,减小角叉菜胶致足跖肿胀程度。但水提取物作用强于乙醇提取物。结论:中药白英有一定的镇痛抗炎作用,其水提取物的镇痛抗炎作用比乙醇提取物效果明显。Abstract: Objective : To investigate the anti-inflammatory and analgesic effects of extracts of Solanum lyratum Thumb. Methods : The anti-inflammatory and analgesic effects of alcohol extract and water extract from Solanum lyratum Thumb were observed by means of acetic acid inducing mouse writhing model,hot plate method,dimethylbenzene inducing ear edema model and carrageenan inducing rat voix pedis swell model. Results :It was found that alcohol extract and water extract from Solanum lyratum Thumb significantly reducing the writhing frequency induced by acetic acid,markedly increasing the pain threshold in mice induced by hot plate,evidently suppressing the mouse's ear edema induced by dimethylbenzene and significantly mitigating the rat voix pedis swell inducing by carrageenan.The role of water extract was better than which of alcohol extract. Conclusions :The water extract from solanum lyratum thumb has notable effects on anti-inflammation and analgesia.
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Key words:
- Solanum lyratum Thumb /
- extract /
- analgesia /
- anti-inflammation
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