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脓毒症是感染引起的机体反应失衡,继而导致的危及生命的多器官功能障碍[1]。脓毒症是对人类生命健康的威胁,是全球范围内感染致死的主要原因[2]。随着人口老龄化日益严重、多重耐药菌不断出现,脓毒症的发病率居高不下[3-4],并以每年1.5%~13%的速率增长[5]。近年来新型冠状病毒肺炎在全球肆虐,研究发现病毒性脓毒症是新冠肺炎患者死亡的主要原因[6],这进一步提升了我们对脓毒症的认识。中医药在新冠肺炎患者治疗过程中发挥了重要作用,使我们对中医药治疗脓毒症的优势和重要性有了新的认识[7]。中医没有对应脓毒症的概念,因此,根据不同的症状将脓毒症归为中医的温病、温毒和伤寒证型。本文针对脓毒症的病因病机和治疗方法两大方面对中医药治疗脓毒症的研究现状进行综述。
Research progress of anti-sepsis treatment using traditional Chinese medicine
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摘要: 脓毒症病机复杂,危及生命,是医学领域的一大难题,临床上多以抗生素、激素、机械通气等治疗为主,缺乏特异性治疗药物,治疗效果欠佳。近年来中医药治疗脓毒症取得了越来越多的进展,本文综述了脓毒症的病因病机和治疗策略,重点阐释了清热解毒、通里攻下、活血化瘀、扶正固本四种疗法,探讨了中医药疗法治疗脓毒症的优势和不足,以期为临床脓毒症的治疗提供参考。Abstract: Sepsis is life-threatening with complex pathogenesis. It is a big problem in the medical field. Clinically, antibiotics, hormones and mechanical ventilation are the main treatments. There is a lack of specific therapeutic drugs. The treatment effect is not good. In recent years, more and more progress has been made in the treatment of sepsis with traditional Chinese medicine. This article reviews the etiology, pathogenesis and treatment strategies of sepsis. It focuses on four therapies, including clearing away heat and detoxification, clearing the interior, activating blood circulation and removing blood stasis, and strengthening the foundation. We further discuss the advantages and disadvantages of traditional Chinese medicine in the treatment of sepsis, in order to provide reference for the clinical treatment of sepsis.
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Key words:
- sepsis /
- pathogenesis /
- traditional Chinese medicine /
- therapy
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