氧化介孔碳球纳米粒作为紫杉醇载体的研究

王欢; 佘岚; 王琳召; 马志强; 张欣荣; 杨峰

doi:10.3969/j.issn.1006-0111.2015.02.005

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氧化介孔碳球纳米粒作为紫杉醇载体的研究

王欢, 佘岚, 王琳召, 马志强, 张欣荣, 杨峰

文章导航 > 药学实践与服务 > 2015 > 33(2): 114-118

王欢, 佘岚, 王琳召, 马志强, 张欣荣, 杨峰. 氧化介孔碳球纳米粒作为紫杉醇载体的研究[J]. 药学实践与服务, 2015, 33(2): 114-118. doi: 10.3969/j.issn.1006-0111.2015.02.005

引用本文:

WANG Huan, SHE Lan, WANG Linzhao, MA Zhiqiang, ZHANG Xinrong, YANG Feng. Oxidized meosporous carbon nanospheres as carriers for paclitaxel[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 114-118. doi: 10.3969/j.issn.1006-0111.2015.02.005

Citation:

WANG Huan, SHE Lan, WANG Linzhao, MA Zhiqiang, ZHANG Xinrong, YANG Feng. Oxidized meosporous carbon nanospheres as carriers for paclitaxel[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 114-118. doi: 10.3969/j.issn.1006-0111.2015.02.005

氧化介孔碳球纳米粒作为紫杉醇载体的研究

doi: 10.3969/j.issn.1006-0111.2015.02.005

1.
福建中医药大学药学院, 福建福州 350108
2.
第二军医大学药学院无机化学教研室, 上海 20433
3.
福建中医药大学药学院, 福建福州 350108;第二军医大学药学院无机化学教研室, 上海 20433

基金项目: 国家自然科学基金项目(21401214);第二军医大学青年启动基金项目(2013QN03)

Oxidized meosporous carbon nanospheres as carriers for paclitaxel

1.
School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China
2.
Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
3.
School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 目的制备氧化介孔碳球纳米粒(oMCN), 考察其理化性质以及作为抗肿瘤药物紫杉醇递送载体的研究。方法采用低浓度水热法合成介孔碳球纳米粒, 观察其形貌特征, 测定其介孔性质参数、粒径、Zeta电位、载药量大小, 利用透析法研究体外释药行为, 用CCK-8法考察体外抗肿瘤活性。结果 oMCN的比表面积为704.63m²/g、孔容积为0.57cm³/g、孔径分布约为3.23nm、平均粒径为140nm、Zeta电位为-36mV、载药量高达45.6%, 72h体外累积释药量为57.6%, 具有良好的药物负载与缓释性能, 对小鼠肺癌LLC细胞具有显著的抑制作用。结论 oMCN作为抗肿瘤药物紫杉醇的载体具有较好的应用前景。
- 介孔碳 /
- 纳米粒 /
- 氧化修饰 /
- 肿瘤 /
- 载药系统
Abstract: Objective To prepare oxidized mesoporous carbon nanospheres and investigate potential application as drug delivery carriers for paclitaxel. Methods Physicochemical properties such as morphology, diameter, pore diameter and pore volume were characterized. Drug-loading capacity was measured and drug release behavior in vitro was investigated by dialysis method. In vitro antitumour effect was evaluated by CCK-8 methods. Results The synthesized oxidized mesoporous carbon nanospheres had an average diameter of 140 nm, Zeta potential of -36 mV, high specific surface area of 704.63 m²/g,high drug-loading capacity of 45.6%. Conclusion Oxidized mesoporous carbon nanospheres have promising application in anti-cancer drug delivery system.
- mesoporous carbon /
- nanoparticles /
- surface modification /
- tumour /
- drug delivery system

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氧化介孔碳球纳米粒作为紫杉醇载体的研究

doi: 10.3969/j.issn.1006-0111.2015.02.005

1. 福建中医药大学药学院, 福建福州 350108

2. 第二军医大学药学院无机化学教研室, 上海 20433

3. 福建中医药大学药学院, 福建福州 350108;第二军医大学药学院无机化学教研室, 上海 20433

基金项目: 国家自然科学基金项目(21401214);第二军医大学青年启动基金项目(2013QN03)

收稿日期: 2014-09-18
修回日期: 2015-01-10

关键词:

介孔碳 /

纳米粒 /

氧化修饰 /

肿瘤 /

载药系统

摘要: 目的制备氧化介孔碳球纳米粒(oMCN), 考察其理化性质以及作为抗肿瘤药物紫杉醇递送载体的研究。方法采用低浓度水热法合成介孔碳球纳米粒, 观察其形貌特征, 测定其介孔性质参数、粒径、Zeta电位、载药量大小, 利用透析法研究体外释药行为, 用CCK-8法考察体外抗肿瘤活性。结果 oMCN的比表面积为704.63m²/g、孔容积为0.57cm³/g、孔径分布约为3.23nm、平均粒径为140nm、Zeta电位为-36mV、载药量高达45.6%, 72h体外累积释药量为57.6%, 具有良好的药物负载与缓释性能, 对小鼠肺癌LLC细胞具有显著的抑制作用。结论 oMCN作为抗肿瘤药物紫杉醇的载体具有较好的应用前景。