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心肌缺血的昼夜节律性与时辰疗法

张恩晖,  王海峰,  陈莉,  刘佃花,  于剑光,  蔡国君

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文章导航 > 药学实践与服务  > 2016 >  34(1): 8-11,47
张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
引用本文: 张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
shu
ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
Citation: ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
shu

心肌缺血的昼夜节律性与时辰疗法

doi: 10.3969/j.issn.1006-0111.2016.01.003
  • 1.

    第二军医大学药学院药理学教研室, 上海 200433;解放军203医院药械科, 黑龙江 齐齐哈尔 161000

  • 2.

    解放军203医院药械科, 黑龙江 齐齐哈尔 161000

  • 3.

    第二军医大学药学院药理学教研室, 上海 200433

Circadian rhythms of myocardial ischemia and chronotherapy

  • 1.

    Department of Pharmacology, School of Pharmacy, the Second Military Medical University, Shanghai 200433, China;Department of Pharmacy and Equipment, No.203 Hospital of PLA, Qiqihar, 161000, China

  • 2.

    Department of Pharmacy and Equipment, No.203 Hospital of PLA, Qiqihar, 161000, China

  • 3.

    Department of Pharmacology, School of Pharmacy, the Second Military Medical University, Shanghai 200433, China

  • 摘要: 临床上心肌缺血(MI)的发作频率伴有昼夜变化,在清晨和傍晚是发病高峰期。产生这一现象主要是受到机体病理生理机制的昼夜节律性以及外界的环境因素影响。目前β-受体阻断剂、硝酸酯类以及钙通道阻滞剂等药物的治疗作用已经被证明受到机体昼夜节律的影响。因此,笔者对MI发作的昼夜节律特点、病理生理机制以及目前临床上的时辰疗法进行综述,并对未来的治疗策略进行探讨。
    Abstract: The occurrence of the clinical manifestations of myocardial ischemia shows clear circadian rhythmicity, and they are unevenly distributed during the 24 h with higher morbidity during the initial hours of the daily activity span and in the late afternoon or early evening. Such temporal patterns result from circadian rhythms in pathophysiological mechanisms plus cyclic environmental stressors that trigger these clinical events. β-receptor antagonist medications, oral nitrate, and calcium channel blocker have been shown to be influenced by the circadian time of their administration. Here we briefly review the characteristics of circadian rhythmicity in MI, the pathophysiological mechanisms as well as the current chronotherapy,and then discuss the future treatment strategies.
  • [1] Portaluppi F,Manfredini R,Fersini C.From a static to a dynamic concept of risk:the circadian epidemiology of cardiovascular events[J].Chronobiol Int,1999,16(1):33-49.
    [2] Haus E,Sackett-Lundeen L,Smolensky MH.Rheumatoid arthritis:circadian rhythms in disease activity,signs and symptoms,and rationale for chronotherapy with corticosteroids and other medications[J].Bull NYU Hosp Jt Dis,2012,70(Suppl 1):3-10.
    [3] Mori H,Nakamura N,Tamura N,et al.Circadian variation of basal total vascular tone and chronotherapy in patients with vasospastic angina pectoris[J].Biomed Pharmacother,2002,56(Suppl 2):339s-344s.
    [4] Thome C,Vajkoczy P,Horn P,et al.Continuous monitoring of regional cerebral blood flow during temporary arterial occlusion in aneurysm surgery[J].J Neurosurg,2001,95(3):402-411.
    [5] Araki H,Koiwaya Y,Nakagaki O,et al.Diurnal distribution of ST-segment elevation and related arrhythmias in patients with variant angina:a study by ambulatory ECG monitoring[J].Circulation,1983,67(5):995-1000.
    [6] Joy M,Pollard CM,Nunan TO.Diurnal variation in exercise responses in angina pectoris[J].Br Heart J,1982,48(2):156-160.
    [7] Ogawa H,Yasue H,Oshima S,et al.Circadian variation of plasma fibrinopeptide A level in patients with variant angina[J].Circulation,1989,80(6):1617-1626.
    [8] Kusama Y,Kodani E,Nakagomi A,et al.Variant angina and coronary artery spasm:the clinical spectrum, pathophysiology,and management[J].J Nippon Med Sch, 2011,78(1):4-12.
    [9] Edahiro R,Sakata Y,Nakatani D,et al.Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction:a prospective observational study in Japan[J].BMJ Open,2014,4(6):e005067.
    [10] Selvi Y,Smolensky MH,Boysan M,et al.Role of patient chronotype on circadian pattern of myocardial infarction:a pilot study[J].Chronobiol Int,2011,28(4):371-377.
    [11] Behar S,Halabi M,Reicher-Reiss H,et al.Circadian variation and possible external triggers of onset of myocardial infarction.SPRINT Study Group[J].Am J Med,1993,94(4):395-400.
    [12] Gilpin EA,Hjalmarson A,Ross JJr.Subgroups of patients with atypical circadian patterns of symptom onset in acute myocardial infarction[J].Am J Cardiol,1990,66(16):7G-11G.
    [13] Hjalmarson A,Gilpin EA,Nicod P,et al.Differing circadian patterns of symptom onset in subgroups of patients with acute myocardial infarction[J].Circulation,1989,80(2):267-275.
    [14] Kanth R,Ittaman S,Rezkalla S.Circadian patterns of ST elevation myocardial infarction in the new millennium[J].Clin Med Res,2013,11(2):66-72.
    [15] Kinjo K,Sato H,Sato H,et al.Circadian variation of the onset of acute myocardial infarction in the Osaka area,1998-1999:characterization of morning and nighttime peaks[J].Jpn Circ J,2001,65(7):617-620.
    [16] Trappolini M,Matteoli S,Borgia MC,et al.Circadian variations in the onset of acute myocardial infarction[J]. Minerva Cardioangiol,2001,49(5):289-296.
    [17] Cohen MC,Rohtla KM,Lavery CE,et al.Meta-analysis of the morning excess of acute myocardial infarction and sudden cardiac death[J].Am J Cardiol,1997,79(11):1512-1516.
    [18] Arntz HR,Willich SN,Oeff M,et al.Circadian variation of sudden cardiac death reflects age-related variability in ventricular fibrillation[J].Circulation,1993,88(5 Pt 1):2284-2289.
    [19] Willich SN,Goldberg RJ,Maclure M,et al.Increased onset of sudden cardiac death in the first three hours after awakening[J].Am J Cardiol,1992,70(1):65-68.
    [20] Hansen O,Johansson BW,Gullberg B.The clinical outcome of acute myocardial infarction is related to the circadian rhythm of myocardial infarction onset[J].Angiology,1993,44(7):509-516.
    [21] Fujita M,Araie E,Yamanishi K,et al.Circadian variation in the success rate of intracoronary thrombolysis for acute myocardial infarction[J].Am J Cardiol,1993,71(15):1369-1371.
    [22] Cooke-Ariel H.Circadian variations in cardiovascular function and their relation to the occurrence and timing of cardiac events[J].Am J Health Syst Pharm,1998,55(Suppl 3):5-11.
    [23] Furlan R,Guzzetti S,Crivellaro W,et al.Continuous 24-hour assessment of the neural regulation of systemic arterial pressure and RR variabilities in ambulant subjects[J].Circulation,1990,81(2):537-547.
    [24] Yasue H,Touyama M,Kato H,et al.Prinzmetal's variant form of angina as a manifestation of alpha-adrenergic receptor-mediated coronary artery spasm:documentation by coronary arteriography[J].Am Heart J,1976,91(2):148-155.
    [25] Wolk R,Gami AS,Garcia-Touchard A,et al.Sleep and cardiovascular disease[J].Curr Probl Cardiol,2005,30(12):625-662.
    [26] Hilfenhaus M.Circadian rhythm of the renin-angiotensin-aldosterone system in the rat[J].Arch Toxicol,1976,36(3-4):305-316.
    [27] Cugini P,Lucia P.Circadian rhythm of the renin-angiotensin-aldosterone system:a summary of our research studies[J].ClinTer,2004,155(7-8):287-291.
    [28] Vaughan DE,Lazos SA,Tong K.Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells.A potential link between the renin-angiotensin system and thrombosis[J].J Clin Invest,1995,95(3):995-1001.
    [29] Brown NJ,Kim KS,Chen YQ,et al.Synergistic effect of adrenal steroids and angiotensin II on plasminogen activator inhibitor-1 production[J].J Clin Endocrinol Metab,2000,85(1):336-344.
    [30] Clow A,Hucklebridge F,Stalder T,et al.The cortisol awakening response:more than a measure of HPA axis function[J].Neurosci Biobehav Rev,2010,35(1):97-103.
    [31] Wilhelm I,Born J,Kudielka BM,et al.Is the cortisol awakening rise a response to awakening?[J].Psychoneuroendocrinology,2007,32(4):358-366.
    [32] Champaneri S,Xu X,Carnethon MR,et al.Diurnal salivary cortisol and urinary catecholamines are associated with diabetes mellitus:the Multi-Ethnic Study of Atherosclerosis[J].Metabolism,2012,61(7):986-995.
    [33] Sahna E,Parlakpinar H,Turkoz Y,et al.Protective effects of melatonin on myocardial ischemia/reperfusion induced infarct size and oxidative changes[J].Physiol Res,2005,54(5):491-495.
    [34] Buxton OM,L'Hermite-Balériaux M,Turek FW,et al.Daytime naps in darkness phase shift the human circadian rhythms of melatonin and thyrotropin secretion[J].Am J Physiol Regul Integr Comp Physiol,2000,278(2):373-382.
    [35] Ludka O,Spinar J,Pozdisek Z,et al.Is there circadian variation of big endothelin and NT-proBNP in patients with severe congestive heart failure？[J]. Vnitr Lek,2010,56(6):488-493.
    [36] Tofler GH,Brezinski D,Schafer AI,et al.Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death[J].N Engl J Med,1987,316(24):1514-1518.
    [37] Quyyumi AA,Crake T,Wright CM,et al.Medical treatment of patients with severe exertional and rest angina:double blind comparison of beta blocker,calcium antagonist,and nitrate[J].Br Heart J,1987,57(6):505-511.
    [38] Conte G,Rigon N,Perrone A.Application of chronotherapy to cardiovascular diseases [J].Recenti Prog Med,1998,89(9):465-469.
    [39] Kuwajima I,Abe K.Effects of the long-acting calcium channel blocker barnidipine hydrochloride on 24-h ambulatory blood pressure[J].Blood Press Monit,2002,7(1):63-65.
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  • 收稿日期:  2014-09-19
  • 修回日期:  2015-04-28

心肌缺血的昼夜节律性与时辰疗法

doi: 10.3969/j.issn.1006-0111.2016.01.003
  • 1. 第二军医大学药学院药理学教研室, 上海 200433;解放军203医院药械科, 黑龙江 齐齐哈尔 161000
  • 2. 解放军203医院药械科, 黑龙江 齐齐哈尔 161000
  • 3. 第二军医大学药学院药理学教研室, 上海 200433
  • 收稿日期: 2014-09-19
  • 修回日期: 2015-04-28

摘要: 临床上心肌缺血(MI)的发作频率伴有昼夜变化,在清晨和傍晚是发病高峰期。产生这一现象主要是受到机体病理生理机制的昼夜节律性以及外界的环境因素影响。目前β-受体阻断剂、硝酸酯类以及钙通道阻滞剂等药物的治疗作用已经被证明受到机体昼夜节律的影响。因此,笔者对MI发作的昼夜节律特点、病理生理机制以及目前临床上的时辰疗法进行综述,并对未来的治疗策略进行探讨。

English Abstract

张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
引用本文: 张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
shu
ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
Citation: ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
shu

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