白念珠菌的高适应性与代谢

毕爽; 胡丹丹; 姜远英; 王彦

doi:10.3969/j.issn.1006-0111.2016.02.006

白念珠菌的高适应性与代谢

doi: 10.3969/j.issn.1006-0111.2016.02.006

第二军医大学药学院新药研究中心, 上海 200433

基金项目: 国家自然科学基金(81273558),上海市浦江人才计划(14PJD001)

The high adaptability and metabolism of Candida albicans

New Drug Research and Development Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 病原真菌白念珠菌对环境具有高度的适应能力,主要体现在与宿主共生时、侵袭宿主时以及在抗真菌药物作用的情况下。白念珠菌生存、繁殖的过程伴随着物质代谢,其可利用的碳源、氮源广泛,并且对营养物质的变化非常敏感。近年来不少研究发现,白念珠菌所处的环境会影响其代谢,与此同时,白念珠菌又可以通过调整代谢过程来适应多变的环境。因此,深入研究白念珠菌代谢与高适应性之间的关联有助于发现新的抗真菌作用靶点。
- 白念珠菌 /
- 高适应性 /
- 代谢
Abstract: Pathogenic Candida albicans has a high degree of adaptability to environment, which is evidenced by its adaptability to various conditions, including its symbiosis with the host, growth in host tissues during invasion, and survival under antifungal treatment. The growth and reproduction of C. albicans is accompanied with metabolism process. C. albicans can use a wide range of carbon and nitrogen sources, and it is sensitive to the alteration of nutrition. Recent studies reveal that the environment affects the metabolism of C. albicans, whilst C. albicans regulates its metabolism to adapt to the environment. Therefore, further study on the relationship between metabolism and high adaptability of C. albicans is helpful to discover novel antifungal targets.
- Candida albicans /
- high adaptability /
- metabolism

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白念珠菌的高适应性与代谢

doi: 10.3969/j.issn.1006-0111.2016.02.006

The high adaptability and metabolism of Candida albicans

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白念珠菌的高适应性与代谢

doi: 10.3969/j.issn.1006-0111.2016.02.006

第二军医大学药学院新药研究中心, 上海 200433

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The high adaptability and metabolism of Candida albicans

New Drug Research and Development Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

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白念珠菌的高适应性与代谢

doi: 10.3969/j.issn.1006-0111.2016.02.006

The high adaptability and metabolism of Candida albicans

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白念珠菌的高适应性与代谢

doi: 10.3969/j.issn.1006-0111.2016.02.006

第二军医大学药学院新药研究中心, 上海 200433

English Abstract

The high adaptability and metabolism of Candida albicans

New Drug Research and Development Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

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