留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

《药学实践与服务》杂志目前不收取审稿费、版面费、加急费等费用,如收到邮件声称是编辑部X编辑,要求加作者微信的,请谨防财产损失!编辑部用于作者校对时绑定微信的邮件通过yxsjzzs@163.com发送,标题是《药学实践与服务》XML数字出版服务微信绑定,请区分开。

选择性二肽基肽酶抑制剂维格列汀与关节痛/骨关节炎发病风险相关性的系统评价

陶伊琳 黄幼明 林惠娥

陶伊琳, 黄幼明, 林惠娥. 选择性二肽基肽酶抑制剂维格列汀与关节痛/骨关节炎发病风险相关性的系统评价[J]. 药学实践与服务, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015
引用本文: 陶伊琳, 黄幼明, 林惠娥. 选择性二肽基肽酶抑制剂维格列汀与关节痛/骨关节炎发病风险相关性的系统评价[J]. 药学实践与服务, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015
TAO Yilin, HUANG Youming, LIN Huie. A systematic review on the correlation between selective dipeptidyl peptidase inhibitor vildagliptin and risk of arthralgia/osteoarthritis[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015
Citation: TAO Yilin, HUANG Youming, LIN Huie. A systematic review on the correlation between selective dipeptidyl peptidase inhibitor vildagliptin and risk of arthralgia/osteoarthritis[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015

选择性二肽基肽酶抑制剂维格列汀与关节痛/骨关节炎发病风险相关性的系统评价

doi: 10.3969/j.issn.1006-0111.2016.06.015

A systematic review on the correlation between selective dipeptidyl peptidase inhibitor vildagliptin and risk of arthralgia/osteoarthritis

  • 摘要: 目的 系统评价选择性二肽基肽酶(DPP)-4抑制剂维格列汀与关节痛/骨关节炎发病风险的相关性。 方法 利用计算机检索PubMed(1978.01-2016.02)、Cochrane Library(2015年第4期)、EMbase(1974.01-2016.02)、CBM(1978.01-2016.02)、CNKI(1978.01-2016.02)、VIP(1989.01-2016.02)的所有相关文献。根据Cochrane系统评价方法筛选维格列汀治疗2型糖尿病发生关节痛/骨关节炎的所有中、英文随机对照试验(RCT),对纳入文献进行数据提取和质量评价后,采用RevMan 5.3软件进行荟萃(Meta)分析。 结果 共纳入10篇文献。Meta分析结果显示:使用维格列汀与使用其他降糖药或安慰剂相比,发生关节痛/骨关节炎的风险更高,差异有统计学意义[RR=1.24,95% CI(1.08,1.44),P=0.003]。进一步分析表明,各种剂量维格列汀组关节痛/骨关节炎的发病风险高于安慰剂组,差异有统计学意义[RR=1.35,95% CI(1.02,1.78),P=0.04]。尤其50 mg,1次/d维格列汀致关节痛/骨关节炎的发病风险显著高于安慰剂组,差异有统计学意义[RR=3.04,95% CI(1.44,6.44),P=0.004]。与其他降糖药比较,发现维格列汀组关节痛/骨关节炎的发病风险更高,差异有统计学意义[RR=1.19,95% CI(1.01,1.41),P=0.04]。 结论 维格列汀可增加关节痛/骨关节炎的发病风险。尤其50 mg,1次/d维格列汀可使关节痛/骨关节炎的发病风险增加2倍。但其远期的安全性还需进行更多大样本、高质量、长期随访的RCT加以验证。
  • [1] Gu D, Reynolds K,Duan X, et al. Prevalence of diabetes and impaired fasting glucose in the Chinese adult population:international collaborative study of cardiovascular disease in Asia (InterASIA)[J]. Diabetologia, 2003, 46(9):1190-1198.
    [2] Yang W, Liu JM, Weng JP, et al. Prevalence of diabetes among men and women in China[J].N Engl J Med, 2010,362(12):1090-1101.
    [3] Deacon CF, Holst JJ. Dipeptidyl peptidase IV inhibitors:a promising new therapeutic approach for the management of type 2 diabetes[J]. Int J Biochem Cell Biol, 2006, 38(5-6):831-844.
    [4] Ahren B, Landin-Olsson M, Jansson PA, et al. Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels and reduces glucagon levels in type 2 diabetes[J]. J Clin Endocrinol Metab, 2004, 89(5):2078-2084.
    [5] Mari A, Sallas WM, He YL, et al. Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed β-cell function in patients with type 2 diabetes[J]. J Clin Endocrinol Metab, 2005,90(8):4888-4894.
    [6] American Diabetes Association. Standards of medical care in diabetes——2015:summary of revisions[J]. Diabetes Care,2015,38(Suppl):S4.
    [7] Hirose T, Suzuki M,Tsumiyama I. Efficacy and safety of vildagliptin as an add-on to insulin with or without metformin in Japanese patients with type 2 diabetes mellitus:a 12-week, double-blind, randomized study[J]. Diabetes Ther,2015,6(4):559-571.
    [8] FDA safety alert. FDA Drug Safety Communication:FDA warns that DPP-4 inhibitors for type 2 diabetes may cause severe joint pain[EB/OL].[2015-08-28] (2016-02-29).http://www.fda.gov/Drugs/DrugSafety/ucm459579.htm.
    [9] Higgins J, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0[EB/OL].[2011-03-01] (2016-02-29).http://handbook.cochrane.org/
    [10] CLAF237A2329. A multicenter, double-blind, randomized, active controlled, parallel group study to compare the effect of 12 weeks treatment with LAF23750 mg bid to 50 mg qd in patients with type 2 diabetes with HbAlc 9-11%[EB/OL].[2007-03-16] (2016-02-29). http://www.novctrd.com/ctrdWebApp/clinicaltrialrepository/displayFile.do?trialResult=2297.
    [11] CLAF237B2224. A multi-center, randomized, double-blind study to evaluate the efficacy and long-term safety of vildagliptin modified release (MR) as add-on therapy to metformin in patients with type 2 diabetes[EB/OL].[2013-09-11] (2016-02-29).http://www.novctrd.com/ctrdWebApp/clinicaltrialrepository/displayFile.do?trialResult=9923.
    [12] Filozof C, Schwartz S, Foley JE. Effect of vildagliptin as add-on therapy to a low-dose metformin[J]. World J Diabetes,2010,1(1):19-26.
    [13] Garber AJ, Schweizer A,Baron MA, et al. Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetesfailing thiazolidinedione monotherapy:a randomized, placebo-controlled study[J]. Diabetes Obes Metab, 2007,9(2):166-174.
    [14] Macauley M, Hollingsworth KG, Smith FE, et al. Effect of vildagliptin on hepatic steatosis[J]. J Clin Endocrinol Metab, 2015,100(4):1578-1585.
    [15] Rosenstock J, Niggli M, Maldonado-Lutomirsky M. Long-term 2-year safety and efficacy of vildagliptin compared with rosiglitazone in drug-naïve patients with type 2 diabetes mellitus[J].Diabetes Obes Metab, 2009,11(6):571-578.
    [16] Strain WD, Lukashevich V,Kothny W, et al. Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL):a 24 week, randomised, double-blind, placebo-controlled study[J]. Lancet,2013,382(9890):409-416.
    [17] Scherbaum WA, Schweizer A, Mari A, et al. Evidence that vildagliptin attenuates deterioration of glycaemic control during 2-year treatment of patients with type 2 diabetes and mild hyperglycaemia[J]. Diabetes Obes Metab,2008,10(11):1114-1124.
    [18] Scherbaum WA, Schweizer A, Mari A, et al. Efficacy and tolerability of vildagliptin in drug-naïve patients with type 2 diabetes and mild hyperglycaemia[J]. Diabetes Obes Metab, 2008,10(8):675-682.
    [19] Matthews DR, Dejager S, Ahren B, et al. Vildagliptin add-on to metformin produces similar efficacy and reduced hypoglycaemic risk compared with glimepiride, with no weight gain:results from a 2-year study[J]. Diabetes Obes Metab,2010,12(9):780-789.
    [20] Ospelt C, Mertens JC, Jüngel A, et al. Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts[J]. Arthritis Rheum, 2010,62(5):1224-1235.
    [21] Yan S, Marguet D, Dobers J, et al. Deficiency of CD26 results in a change of cytokine and immunoglobulin secretion after stimulation by pokeweed mitogen[J]. Eur J Immunol,2003,33(6):1519-1527.
    [22] K nig A, Krenn V, Toksoy A, et al. Mig,GRO alpha and RANTES messenger RNA expression in lining layer, infiltrates and different leucocyte populations of synovial tissue from patients with rheumatoid arthritis, psoriatic arthritis and osteoarthritis[J]. Virchows Arch,2000,436(5):449-458.
    [23] Loetscher P, Moser B. Homing chemokines in rheumatoid arthritis[J]. Arthritis Res,2002,4(4):233-236.
    [24] Sedo A, Duke-Cohan JS, Balaziova E, et al. Dipeptidyl peptidase IV activity and/or structure homologs:contributing factors in the pathogenesis of rheumatoid arthritis[J]. Arthritis Res Ther,2005,7:253-269.
    [25] Busso N, Wagtmann N, Herling C, et al. Circulating CD26 is negatively associated with inflammation in human and experimental arthritis[J]. Am J Pathol,2005,166(2):433-442.
  • [1] 冯广伟, 张静, 刘阳熙, 崔敏.  消化道穿孔患者术后继发念珠菌血流感染的病例分析 . 药学实践与服务, 2025, 43(): 1-4. doi: 10.12206/j.issn.2097-2024.202312012
    [2] 邵尉, 袁妮, 刘叶, 于飞, 柳莹, 王峰.  丙戊酸钠与左乙拉西坦治疗儿童癫痫病的成本-效果分析 . 药学实践与服务, 2025, 43(): 1-5. doi: 10.12206/j.issn.2097-2024.202408046
    [3] 陶宫佳, 陈林林, 宋泽成, 刘梦肖, 王彦.  苦参碱及衍生物的抗炎作用及其机制研究进展 . 药学实践与服务, 2025, 43(4): 1-7. doi: 10.12206/j.issn.2097-2024.202406035
    [4] 王燕, 方铭, 宋红卫, 钟超, 徐峰, 周婷.  2021−2023年某院药品不良反应的特点分析 . 药学实践与服务, 2025, 43(4): 200-204. doi: 10.12206/j.issn.2097-2024.202404041
    [5] 曹金发, 钟玲, 何苗, 田泾.  炎症性肠病合并心房颤动患者的用药分析与监护 . 药学实践与服务, 2025, 43(): 1-4. doi: 10.12206/j.issn.2097-2024.202403004
    [6] 杨贺英, 罗彩萍, 彭婷, 梁文仪, 沈颂章, 苏娟.  花椒生物碱富集纯化工艺优化及其成分分析 . 药学实践与服务, 2025, 43(2): 75-81. doi: 10.12206/j.issn.2097-2024.202404066
    [7] 富子菲, 陈静.  非洲部分地区药品品种供应分析 . 药学实践与服务, 2025, 43(): 1-10. doi: 10.12206/j.issn.2097-2024.202407040
    [8] 张岩, 李炎君, 刘家荟, 邓娇, 原苑, 张敬一.  药物性肝损伤不良反应分析 . 药学实践与服务, 2025, 43(1): 26-29, 40. doi: 10.12206/j.issn.2097-2024.202404034
    [9] 李想, 陆鸿远, 张明玉, 高欢, 姚东, 许子华.  米格列醇激活UCP1介导棕色脂肪改善冷暴露小鼠损伤的研究 . 药学实践与服务, 2025, 43(1): 1-5, 16. doi: 10.12206/j.issn.2097-2024.202404005
    [10] 曹奇, 张嘉宝, 王培.  基于无监督自动降维分析与手动圈门联用的骨骼肌髓系细胞多色流式分析方法 . 药学实践与服务, 2025, 43(3): 118-122. doi: 10.12206/j.issn.2097-2024.202404077
    [11] 刘丽艳, 余小翠, 孙传铎.  纳武利尤单抗治疗非小细胞肺癌有效性及安全性的Meta分析 . 药学实践与服务, 2024, 42(10): 451-456. doi: 10.12206/j.issn.2097-2024.202310044
    [12] 张艺昕, 关欣怡, 王博宁, 闻俊, 洪战英.  二氢吡啶类钙离子拮抗药物手性分析及其立体选择性药动学研究进展 . 药学实践与服务, 2024, 42(8): 319-324. doi: 10.12206/j.issn.2097-2024.202308062
    [13] 史生辉, 石飞, 雷琼, 王亚峰, 吴雪花.  青藏高原肺结核合并念珠菌感染患者的病原菌分布特点及耐药率分析 . 药学实践与服务, 2024, 42(6): 260-262, 272. doi: 10.12206/j.issn.2097-2024.202304014
    [14] 戴菲菲, 傅翔, 陈琼年, 俞苏纯.  上海某二级医院革兰阴性菌流行特征的回顾性分析 . 药学实践与服务, 2024, 42(12): 528-532. doi: 10.12206/j.issn.2097-2024.202305005
    [15] 刘依秦, 王超群, 邱娇娜.  胆宁片预处理在糖尿病患者结肠镜检查前的应用效果分析 . 药学实践与服务, 2024, 42(9): 407-410. doi: 10.12206/j.issn.2097-2024.202407037
    [16] 瞿文君, 白若楠, 崔力, 周琰.  基于联合库存的公立医院多院区药品采购模式分析 . 药学实践与服务, 2024, 42(7): 315-318. doi: 10.12206/j.issn.2097-2024.202401002
    [17] 张晶晶, 索丽娜, 郑兆红.  89例细菌性肝脓肿的临床特征及抗感染治疗分析 . 药学实践与服务, 2024, 42(6): 267-272. doi: 10.12206/j.issn.2097-2024.202302039
    [18] 崔晓林, 付晓菲, 杜艳红, 刘娟, 朱茜, 刘子祺.  临床药师参与吉瑞替尼致QTc间期延长的病例分析 . 药学实践与服务, 2024, 42(6): 263-266. doi: 10.12206/j.issn.2097-2024.202309050
    [19] 尹小娟, 台力丽, 肖俊峰, 季波.  铜绿假单胞菌合并按蚊伊丽莎白菌肺部感染的病例分析 . 药学实践与服务, 2024, 42(5): 223-226. doi: 10.12206/j.issn.2097-2024.202310042
    [20] 姚瑞阳, 于海征, 李耀盺, 张磊.  丹参FBXL 基因家族的鉴定和表达模式分析 . 药学实践与服务, 2024, 42(11): 461-470. doi: 10.12206/j.issn.2097-2024.202407034
  • 期刊类型引用(1)

    1. 李新露,黄劼,董凌莉,钟继新. 二肽基肽酶4抑制剂在风湿免疫病中的潜在作用. 医药导报. 2023(02): 166-172 . 百度学术

    其他类型引用(0)

  • 加载中
计量
  • 文章访问数:  3975
  • HTML全文浏览量:  335
  • PDF下载量:  303
  • 被引次数: 1
出版历程
  • 收稿日期:  2016-03-19
  • 修回日期:  2016-06-16

选择性二肽基肽酶抑制剂维格列汀与关节痛/骨关节炎发病风险相关性的系统评价

doi: 10.3969/j.issn.1006-0111.2016.06.015

摘要: 目的 系统评价选择性二肽基肽酶(DPP)-4抑制剂维格列汀与关节痛/骨关节炎发病风险的相关性。 方法 利用计算机检索PubMed(1978.01-2016.02)、Cochrane Library(2015年第4期)、EMbase(1974.01-2016.02)、CBM(1978.01-2016.02)、CNKI(1978.01-2016.02)、VIP(1989.01-2016.02)的所有相关文献。根据Cochrane系统评价方法筛选维格列汀治疗2型糖尿病发生关节痛/骨关节炎的所有中、英文随机对照试验(RCT),对纳入文献进行数据提取和质量评价后,采用RevMan 5.3软件进行荟萃(Meta)分析。 结果 共纳入10篇文献。Meta分析结果显示:使用维格列汀与使用其他降糖药或安慰剂相比,发生关节痛/骨关节炎的风险更高,差异有统计学意义[RR=1.24,95% CI(1.08,1.44),P=0.003]。进一步分析表明,各种剂量维格列汀组关节痛/骨关节炎的发病风险高于安慰剂组,差异有统计学意义[RR=1.35,95% CI(1.02,1.78),P=0.04]。尤其50 mg,1次/d维格列汀致关节痛/骨关节炎的发病风险显著高于安慰剂组,差异有统计学意义[RR=3.04,95% CI(1.44,6.44),P=0.004]。与其他降糖药比较,发现维格列汀组关节痛/骨关节炎的发病风险更高,差异有统计学意义[RR=1.19,95% CI(1.01,1.41),P=0.04]。 结论 维格列汀可增加关节痛/骨关节炎的发病风险。尤其50 mg,1次/d维格列汀可使关节痛/骨关节炎的发病风险增加2倍。但其远期的安全性还需进行更多大样本、高质量、长期随访的RCT加以验证。

English Abstract

陶伊琳, 黄幼明, 林惠娥. 选择性二肽基肽酶抑制剂维格列汀与关节痛/骨关节炎发病风险相关性的系统评价[J]. 药学实践与服务, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015
引用本文: 陶伊琳, 黄幼明, 林惠娥. 选择性二肽基肽酶抑制剂维格列汀与关节痛/骨关节炎发病风险相关性的系统评价[J]. 药学实践与服务, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015
TAO Yilin, HUANG Youming, LIN Huie. A systematic review on the correlation between selective dipeptidyl peptidase inhibitor vildagliptin and risk of arthralgia/osteoarthritis[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015
Citation: TAO Yilin, HUANG Youming, LIN Huie. A systematic review on the correlation between selective dipeptidyl peptidase inhibitor vildagliptin and risk of arthralgia/osteoarthritis[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015
参考文献 (25)

目录

/

返回文章
返回