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选择性二肽基肽酶抑制剂维格列汀与关节痛/骨关节炎发病风险相关性的系统评价

陶伊琳 黄幼明 林惠娥

陶伊琳, 黄幼明, 林惠娥. 选择性二肽基肽酶抑制剂维格列汀与关节痛/骨关节炎发病风险相关性的系统评价[J]. 药学实践与服务, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015
引用本文: 陶伊琳, 黄幼明, 林惠娥. 选择性二肽基肽酶抑制剂维格列汀与关节痛/骨关节炎发病风险相关性的系统评价[J]. 药学实践与服务, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015
TAO Yilin, HUANG Youming, LIN Huie. A systematic review on the correlation between selective dipeptidyl peptidase inhibitor vildagliptin and risk of arthralgia/osteoarthritis[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015
Citation: TAO Yilin, HUANG Youming, LIN Huie. A systematic review on the correlation between selective dipeptidyl peptidase inhibitor vildagliptin and risk of arthralgia/osteoarthritis[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015

选择性二肽基肽酶抑制剂维格列汀与关节痛/骨关节炎发病风险相关性的系统评价

doi: 10.3969/j.issn.1006-0111.2016.06.015

A systematic review on the correlation between selective dipeptidyl peptidase inhibitor vildagliptin and risk of arthralgia/osteoarthritis

  • 摘要: 目的 系统评价选择性二肽基肽酶(DPP)-4抑制剂维格列汀与关节痛/骨关节炎发病风险的相关性。 方法 利用计算机检索PubMed(1978.01-2016.02)、Cochrane Library(2015年第4期)、EMbase(1974.01-2016.02)、CBM(1978.01-2016.02)、CNKI(1978.01-2016.02)、VIP(1989.01-2016.02)的所有相关文献。根据Cochrane系统评价方法筛选维格列汀治疗2型糖尿病发生关节痛/骨关节炎的所有中、英文随机对照试验(RCT),对纳入文献进行数据提取和质量评价后,采用RevMan 5.3软件进行荟萃(Meta)分析。 结果 共纳入10篇文献。Meta分析结果显示:使用维格列汀与使用其他降糖药或安慰剂相比,发生关节痛/骨关节炎的风险更高,差异有统计学意义[RR=1.24,95% CI(1.08,1.44),P=0.003]。进一步分析表明,各种剂量维格列汀组关节痛/骨关节炎的发病风险高于安慰剂组,差异有统计学意义[RR=1.35,95% CI(1.02,1.78),P=0.04]。尤其50 mg,1次/d维格列汀致关节痛/骨关节炎的发病风险显著高于安慰剂组,差异有统计学意义[RR=3.04,95% CI(1.44,6.44),P=0.004]。与其他降糖药比较,发现维格列汀组关节痛/骨关节炎的发病风险更高,差异有统计学意义[RR=1.19,95% CI(1.01,1.41),P=0.04]。 结论 维格列汀可增加关节痛/骨关节炎的发病风险。尤其50 mg,1次/d维格列汀可使关节痛/骨关节炎的发病风险增加2倍。但其远期的安全性还需进行更多大样本、高质量、长期随访的RCT加以验证。
  • [1] Gu D, Reynolds K,Duan X, et al. Prevalence of diabetes and impaired fasting glucose in the Chinese adult population:international collaborative study of cardiovascular disease in Asia (InterASIA)[J]. Diabetologia, 2003, 46(9):1190-1198.
    [2] Yang W, Liu JM, Weng JP, et al. Prevalence of diabetes among men and women in China[J].N Engl J Med, 2010,362(12):1090-1101.
    [3] Deacon CF, Holst JJ. Dipeptidyl peptidase IV inhibitors:a promising new therapeutic approach for the management of type 2 diabetes[J]. Int J Biochem Cell Biol, 2006, 38(5-6):831-844.
    [4] Ahren B, Landin-Olsson M, Jansson PA, et al. Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels and reduces glucagon levels in type 2 diabetes[J]. J Clin Endocrinol Metab, 2004, 89(5):2078-2084.
    [5] Mari A, Sallas WM, He YL, et al. Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed β-cell function in patients with type 2 diabetes[J]. J Clin Endocrinol Metab, 2005,90(8):4888-4894.
    [6] American Diabetes Association. Standards of medical care in diabetes——2015:summary of revisions[J]. Diabetes Care,2015,38(Suppl):S4.
    [7] Hirose T, Suzuki M,Tsumiyama I. Efficacy and safety of vildagliptin as an add-on to insulin with or without metformin in Japanese patients with type 2 diabetes mellitus:a 12-week, double-blind, randomized study[J]. Diabetes Ther,2015,6(4):559-571.
    [8] FDA safety alert. FDA Drug Safety Communication:FDA warns that DPP-4 inhibitors for type 2 diabetes may cause severe joint pain[EB/OL].[2015-08-28] (2016-02-29).http://www.fda.gov/Drugs/DrugSafety/ucm459579.htm.
    [9] Higgins J, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0[EB/OL].[2011-03-01] (2016-02-29).http://handbook.cochrane.org/
    [10] CLAF237A2329. A multicenter, double-blind, randomized, active controlled, parallel group study to compare the effect of 12 weeks treatment with LAF23750 mg bid to 50 mg qd in patients with type 2 diabetes with HbAlc 9-11%[EB/OL].[2007-03-16] (2016-02-29). http://www.novctrd.com/ctrdWebApp/clinicaltrialrepository/displayFile.do?trialResult=2297.
    [11] CLAF237B2224. A multi-center, randomized, double-blind study to evaluate the efficacy and long-term safety of vildagliptin modified release (MR) as add-on therapy to metformin in patients with type 2 diabetes[EB/OL].[2013-09-11] (2016-02-29).http://www.novctrd.com/ctrdWebApp/clinicaltrialrepository/displayFile.do?trialResult=9923.
    [12] Filozof C, Schwartz S, Foley JE. Effect of vildagliptin as add-on therapy to a low-dose metformin[J]. World J Diabetes,2010,1(1):19-26.
    [13] Garber AJ, Schweizer A,Baron MA, et al. Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetesfailing thiazolidinedione monotherapy:a randomized, placebo-controlled study[J]. Diabetes Obes Metab, 2007,9(2):166-174.
    [14] Macauley M, Hollingsworth KG, Smith FE, et al. Effect of vildagliptin on hepatic steatosis[J]. J Clin Endocrinol Metab, 2015,100(4):1578-1585.
    [15] Rosenstock J, Niggli M, Maldonado-Lutomirsky M. Long-term 2-year safety and efficacy of vildagliptin compared with rosiglitazone in drug-naïve patients with type 2 diabetes mellitus[J].Diabetes Obes Metab, 2009,11(6):571-578.
    [16] Strain WD, Lukashevich V,Kothny W, et al. Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL):a 24 week, randomised, double-blind, placebo-controlled study[J]. Lancet,2013,382(9890):409-416.
    [17] Scherbaum WA, Schweizer A, Mari A, et al. Evidence that vildagliptin attenuates deterioration of glycaemic control during 2-year treatment of patients with type 2 diabetes and mild hyperglycaemia[J]. Diabetes Obes Metab,2008,10(11):1114-1124.
    [18] Scherbaum WA, Schweizer A, Mari A, et al. Efficacy and tolerability of vildagliptin in drug-naïve patients with type 2 diabetes and mild hyperglycaemia[J]. Diabetes Obes Metab, 2008,10(8):675-682.
    [19] Matthews DR, Dejager S, Ahren B, et al. Vildagliptin add-on to metformin produces similar efficacy and reduced hypoglycaemic risk compared with glimepiride, with no weight gain:results from a 2-year study[J]. Diabetes Obes Metab,2010,12(9):780-789.
    [20] Ospelt C, Mertens JC, Jüngel A, et al. Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts[J]. Arthritis Rheum, 2010,62(5):1224-1235.
    [21] Yan S, Marguet D, Dobers J, et al. Deficiency of CD26 results in a change of cytokine and immunoglobulin secretion after stimulation by pokeweed mitogen[J]. Eur J Immunol,2003,33(6):1519-1527.
    [22] K nig A, Krenn V, Toksoy A, et al. Mig,GRO alpha and RANTES messenger RNA expression in lining layer, infiltrates and different leucocyte populations of synovial tissue from patients with rheumatoid arthritis, psoriatic arthritis and osteoarthritis[J]. Virchows Arch,2000,436(5):449-458.
    [23] Loetscher P, Moser B. Homing chemokines in rheumatoid arthritis[J]. Arthritis Res,2002,4(4):233-236.
    [24] Sedo A, Duke-Cohan JS, Balaziova E, et al. Dipeptidyl peptidase IV activity and/or structure homologs:contributing factors in the pathogenesis of rheumatoid arthritis[J]. Arthritis Res Ther,2005,7:253-269.
    [25] Busso N, Wagtmann N, Herling C, et al. Circulating CD26 is negatively associated with inflammation in human and experimental arthritis[J]. Am J Pathol,2005,166(2):433-442.
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选择性二肽基肽酶抑制剂维格列汀与关节痛/骨关节炎发病风险相关性的系统评价

doi: 10.3969/j.issn.1006-0111.2016.06.015

摘要: 目的 系统评价选择性二肽基肽酶(DPP)-4抑制剂维格列汀与关节痛/骨关节炎发病风险的相关性。 方法 利用计算机检索PubMed(1978.01-2016.02)、Cochrane Library(2015年第4期)、EMbase(1974.01-2016.02)、CBM(1978.01-2016.02)、CNKI(1978.01-2016.02)、VIP(1989.01-2016.02)的所有相关文献。根据Cochrane系统评价方法筛选维格列汀治疗2型糖尿病发生关节痛/骨关节炎的所有中、英文随机对照试验(RCT),对纳入文献进行数据提取和质量评价后,采用RevMan 5.3软件进行荟萃(Meta)分析。 结果 共纳入10篇文献。Meta分析结果显示:使用维格列汀与使用其他降糖药或安慰剂相比,发生关节痛/骨关节炎的风险更高,差异有统计学意义[RR=1.24,95% CI(1.08,1.44),P=0.003]。进一步分析表明,各种剂量维格列汀组关节痛/骨关节炎的发病风险高于安慰剂组,差异有统计学意义[RR=1.35,95% CI(1.02,1.78),P=0.04]。尤其50 mg,1次/d维格列汀致关节痛/骨关节炎的发病风险显著高于安慰剂组,差异有统计学意义[RR=3.04,95% CI(1.44,6.44),P=0.004]。与其他降糖药比较,发现维格列汀组关节痛/骨关节炎的发病风险更高,差异有统计学意义[RR=1.19,95% CI(1.01,1.41),P=0.04]。 结论 维格列汀可增加关节痛/骨关节炎的发病风险。尤其50 mg,1次/d维格列汀可使关节痛/骨关节炎的发病风险增加2倍。但其远期的安全性还需进行更多大样本、高质量、长期随访的RCT加以验证。

English Abstract

陶伊琳, 黄幼明, 林惠娥. 选择性二肽基肽酶抑制剂维格列汀与关节痛/骨关节炎发病风险相关性的系统评价[J]. 药学实践与服务, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015
引用本文: 陶伊琳, 黄幼明, 林惠娥. 选择性二肽基肽酶抑制剂维格列汀与关节痛/骨关节炎发病风险相关性的系统评价[J]. 药学实践与服务, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015
TAO Yilin, HUANG Youming, LIN Huie. A systematic review on the correlation between selective dipeptidyl peptidase inhibitor vildagliptin and risk of arthralgia/osteoarthritis[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015
Citation: TAO Yilin, HUANG Youming, LIN Huie. A systematic review on the correlation between selective dipeptidyl peptidase inhibitor vildagliptin and risk of arthralgia/osteoarthritis[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015
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