环磷酰胺致畸性的体外研究
Studies on teratogenicity of cyclophosphamide in vitro
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摘要: 环磷酸胺是临床上常用的抗肿瘤药物和免疫抑制剂,是化学致畸物研究的代表药,体外致畸试验方法是研究致畸作用及机理的有效方法之一;本文以环磷酰胺为例,从前致畸原体外活化、体外给药方法及试验方法几个方面较系统也介绍了该药体外致畸的研究情况,这对其它化学物质的致畸研究可能有一定参考价值.Abstract: Cyclophosphamide is a commonly used antitumor and immunosuppressive drug as well as an important chemical teratogen after exposure in vivo. Methods and models in vitro were effecient in teratogenicity research. In this review, general cousiderations about activation of proteratogen, methods of administation and testing in vitro are introduced. Furthermore, it can be useful for other teratogens studies.
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Key words:
- cyclophosphamide /
- teratogenicity /
- in vitro
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