眼镜蛇毒素抗类风湿性关节炎实验研究
Anti inflammatory action of cobra(Naja naja)venom
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摘要: 目的 观察眼镜蛇(Naja naja)毒素的抗炎作用。方法 采用大鼠佐剂性关节炎和大鼠棉球肉芽肿模型。结果 眼镜蛇毒素对佐剂性关节炎模型大鼠的踝关节肿胀程度无明显影响,但使大鼠棉球肉芽肿重量显着减轻(P<0.05).结论 眼镜蛇毒素对关节滑膜增生可能有一定保护或逆转功能。
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关键词:
- 眼镜蛇(Najanaja)毒素 /
- 大鼠 /
- 类风湿性关节炎
Abstract: ORJECTIVE:To observe the antiinflammatory action of cobra(Naja naja)venom.METHODS Cobra venom was administered subcutaneously at doses of 2μg/kg,10μg/kg and 50μg/kg for 20 days after Freund complete adjuvant infection and intragastrically at dose of 25mg/kg for 7 days after cotton pellets planted in rats.RESULTS Cobra venom had no effect on the edema induced by adjuvant,but inhibited markedly granuloma information caused by cotton pellets in rats.CONCLUSION Cobra venom may be effective on synovitis.-
Key words:
- cobra(Naja naja)venom /
- rat /
- rheumatoid arthritis
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