乌拉地尔治疗急性左心衰竭与其它血管扩张剂疗效比较
Comparison of clinical efficacy between urapidil and other vasodilators in acute left heart failure
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摘要: 目的:评价乌拉地尔与其它血管扩张剂治疗急性左心衰竭的疗效。方法:80例急性左心衰竭患者随机分为4组:乌拉地尔组(19例)、酚妥拉明组(21例)、硝普钠组(16例)和硝酸甘油组(24例),观察记录治疗前后的呼吸困难、心率、血压及肺部罗音的变化。结果:乌拉地尔组和硝普钠组对呼吸困难缓解率分别为94.7%和93.8%(P>0.05),硝酸甘油组为47.7%(P<0.01);酚妥拉明组心率增快发生率为66.7%,乌拉地尔组为5.3%(P<0.01)。硝普钠组血压下降和低血压发生率为31.3%,乌拉地尔组为5.3%(P<0.05);乌拉地尔组和酚妥拉明组减少肺部罗音有效率分别为94.7%和95.2%(P>0.05),硝酸甘油组为58.3%(P<0.05)。结论:乌拉地尔可以作为救治急性左心衰竭的首选药物之一。Abstract: Objective :To evaluate the clinical efficacy between urapidil and other vasodilators in acute left heart failure. Methods : 80 patients with acute left heart failure were randomly divided into 4 groups: urapidil group(n=19),phentolamine group(n=21),sodium nitroprusside group(n=16),nitroglycerin group(n=24).The change of dyspneic respiration,heart rate,blood preasure,and lung rales were recorded respectively in the process of the treatment. Results :Remission rate of dyspnea were 94.7% and 93.8% in urapidil group and sodium nitroprusside group respectively(P>0.05),nitroglycerin group was 47.7%(P<0.01).Incidence of heart rate acceleration were 66.7% and 5.3% in phentolamine group and urapidil group respectively(P<0.01).Incidence of blood pressure lowering and hypotension were 31.3% and 5.3% in sodium nitroprusside group and urapidil group respectively(P<0.05).Effective rate of reducing lung rales were 94.7% and 95.2% respectively(P>0.05),nitroglycerin group was 58.3%(P<0.05). Conclusion :The result proved that urapidil could be used as first aid for patients with acute left heart failure.
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Key words:
- urapidil /
- vasodilators /
- acute left heart failure /
- cure
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