丹参素钠对麻醉犬心肌耗氧量的影响
Effect of Sodium danshensu on oxygen consumption in anesthetized dogs
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摘要: 目的: 观察丹参素钠静注对麻醉犬心肌耗氧量的影响。 方法: 采用心导管法检测冠状静脉窦血样及动脉血氧等指标,研究丹参素钠对缺血心肌的作用。 结果: 给药后5 min到120 min的各时间点,丹参素钠可明显增加麻醉犬心输出量、冠脉流量;降低冠脉阻力;降低总外周阻力;明显降低心肌氧摄取率,与生理盐水组比较有显著差异,作用强度与剂量有一定的量效关系。 结论: 丹参素钠对心肌缺血损伤具有一定预防治疗作用。Abstract: Objective To investigate the effects of Sodium danshensu on myocardial oxygen consumption in dogs. Methods The parameters including coronary blood flow,myocardial oxygen consumption and myocardial oxygen uptake rate in normal anaesthetic dogs were used to study the effects of Sodium danshensu on ischemic myocardium. Results Cardiac output and coronary blood flow were increased significantly and myocardial oxygen uptake rate and myocardial oxygen consumption were remarkable decreased in the periods of 5 min to 120 min when Sodium danshensu given to dogs,which had difference with that of normal saline group(P<0.01). Conclusion Sodium danshensu had protective effects on the ischemic myocardium.
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Key words:
- Sodium danshensu /
- hemodynamics /
- myocardium oxygen consumption /
- dog
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