消化系统毒理学生物标志物研究新进展

王洁; 夏振娜; 车爱萍; 袁伯俊; 陆国才

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

消化系统毒理学生物标志物研究新进展

王洁, 夏振娜, 车爱萍, 袁伯俊, 陆国才

文章导航 > 药学实践与服务 > 2011 > 29(4): 247-250

王洁, 夏振娜, 车爱萍, 袁伯俊, 陆国才. 消化系统毒理学生物标志物研究新进展[J]. 药学实践与服务, 2011, 29(4): 247-250.

引用本文:

王洁, 夏振娜, 车爱萍, 袁伯俊, 陆国才. 消化系统毒理学生物标志物研究新进展[J]. 药学实践与服务, 2011, 29(4): 247-250.

WANG Jie, XIA Zhen-na, CHE Ai-ping, YUAN Bo-jun, LU Guo-cai. Progress on the study of toxicologic biomarkers in digestive system[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 247-250.

Citation:

WANG Jie, XIA Zhen-na, CHE Ai-ping, YUAN Bo-jun, LU Guo-cai. Progress on the study of toxicologic biomarkers in digestive system[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 247-250.

消化系统毒理学生物标志物研究新进展

第二军医大学新药评价中心,上海 200433

基金项目: "重大新药创制"科技重大专项 (2008ZXJ09014-0095, 2009ZX09301-011).

Progress on the study of toxicologic biomarkers in digestive system

Center for New Drug Evaluation, Second Military Medical University, Shanghai 200433,China

摘要: 毒理学生物标志物是机体对化学物质毒性剂量暴露后的生物学变化,可特异性地反映毒性效应。对毒理学生物标志物进行全面评估,并尽快应用于临床,可以有效地减少药物研发风险。新近发现与消化系统毒理学研究有关的生物标志物有肠脂肪酸结合蛋白、二胺氧化酶、牛磺酸、山梨醇脱氢酶、羧酸酯酶-2、转化生长因子β1、组织多肽特异性抗原、再生基因蛋白Reg4、S100蛋白、血清糖蛋白YKL-40等。
- 生物标志物 /
- 消化系统 /
- 毒理学
Abstract: Toxicologic biomarkers,indicating specific toxic effects, are biological changes of body when exposured to toxic doses of chemicals. Comprehensive assessment and clinical application of toxicologic biomarkers at early stage could effectively reduce the risk in drug research and development. Recently discovered toxicological biomarkers of the digestive system were intestinal fatty acid binding protein, diamine oxidase, taurine, sorbitol dehydrogenase, carboxylesterase-2, transforming growth factor β1, tissue polypeptide specific antigen, regenerating gene protein Reg4, S100 protein and serum glycoprotein YKL-40 etc.
- biomarkers /
- digestive system /
- toxicology

[1]	Walker CH, Hopkin SP, Sibly RM, et al. National Research Council. Committee on biological markers[J]. Environ Health Persp,1987, 74:3.
[2]	Liu RZ, Li XD, Godbout R. A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis[J]. Genomics, 2008, 92: 436.
[3]	Vreugdenhil A, Wolters VM, Van den Neucker A, et al. 193 Enhanced I-FABP levels in children with celiac disease rapidly recover aAfter gluten free diet. Potential marker for diagnosis and follow-up of celiac disease[J]. Gastroenterology, 2009, 136: A36.
[4]	Luk GD, Vaughan WP, Burke PJ, et al. Diamine oxidase as a plasma marker of rat intestinal mucosaln injury and regeneration after administration of 1-β-d-arabinofuranosylcytosine[J]. Cancer Res,1981, 41:2334.
[5]	Kenji M, Yasuhide K, Hidenobu M, et al. Diamine oxidase, a plasma biomarker in rats to GI tract toxicity of oral uorouracil anti-cancer drugs[J]. Toxicology, 2006, 217:23.
[6]	Huang JS, Chuang LY, Gu JY. Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells[J]. Toxical Appl Pharm, 2008,233: 220.
[7]	Ghandforoush-Sattari M, Mashayekh S. Evaluation of taurine as a biomarker of liver damage in paracetamol poisoning[J]. Eur J Pharmacol, 2008, 581:171.
[8]	Ramaiah SK. A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters[J]. Toxicology. 2007, 45: 1551.
[9]	Ozer J, Ratner M, Shaw M, et al. The current state of serum biomarkers of hepatotoxicity[J]. Toxicology, 2008, 245: 194.
[10]	Allen C, Abdolsamad B, Philip M, et al. Hydrolysis of pyrethroids by human and rat tissues: Examination of intestinal liver and serum carboxylesterases[J]. Toxicol Appl Pharm, 2007, 221: 1.
[11]	Gressner S, Jafari ME, Frank Y, et al. Evaluation of serum percent trisialotransferrin as potential predictive biomarker of hepatocellular dedifferentiation in chronic liver disease[J]. Clin Chim Acta, 2009, 403:188.
[12]	蒋莹, 阿依吐拉. 转化生长因子β1和基质金属蛋白酶抑制因子β1在肝硬化组织中的表达及其临床意义[J]. 临床肝胆病杂志, 2009,25:39.
[13]	Duller P, Stiegler M, Schweiger T, et al. Sensitive serum parameters for hepatocellular carcinoma recurrence monitoring after liver transplantation: A case report[J]. Transpl P, 2007, 39:3281.
[14]	Takayama R, Nakagawa H, Sawaki A, et al. Serum tumor antigen Reg4 as a diagnostic biomarker in pancreatic ductal adenocarcinoma[J]. Gastroenterology, 2008, 134: A695.
[15]	Salama I, Malone PS, Mihaimeed F. A review of the S100 proteins in cancer[J]. Eur J Surg Onc, 2008, 34:357.
[16]	Oliveira-Cunha M, Siriwardena AK, Byers R. Molecular diagnosis in pancreatic cancer[J]. Diagn Hist, 2008, 14:214-222.
[17]	Kacira T, Hanimoglu H, Kucur M, et al. Elevated cerebrospinal fluid and serum YKL-40 levels are not associated with symptomatic vasospasm in patients with aneurysmal subarachnoid haemorrhage[J]. J Clin Neurosci, 2008,15:1011.
[18]	Scheer M, Wild S, Kuebler AC, et al. YKL-40 as prognostic biomarker in patients with oral cancer[J]. J Cranio Maxill Surg, 2008, 36: S190.
[19]	Jain KK. The Handbook of Biomarkers[M]. New York: Humana Press, 2010:1-84.
[20]	Azuaje F. Bioinformatics and Biomarker Discovery [M]. Chichester: Wiley-Blackwell, 2010:173.

[1]	张强, 李静, 刘越, 储晓琴. 基于网络药理学与分子对接技术研究制痂酊治疗Ⅱ度烧伤的作用机制 . 药学实践与服务, 2025, 43(): 1-7. doi: 10.12206/j.issn.2097-2024.202307014
[2]	杨贺英, 罗彩萍, 彭婷, 梁文仪, 沈颂章, 苏娟. 花椒生物碱富集纯化工艺优化及其成分分析 . 药学实践与服务, 2025, 43(2): 1-7. doi: 10.12206/j.issn.2097-2024.202404066
[3]	周娇, 郑建雨, 王思真, 杨峰. mRNA肿瘤疫苗非病毒递送系统研究进展 . 药学实践与服务, 2025, 43(): 1-8. doi: 10.12206/j.issn.2097-2024.202410034
[4]	陈静, 何瑞华, 翁月, 徐熠, 刘静, 黄瑾. 基于网络药理学和分子对接技术探究定清片活性成分治疗白血病的作用机制 . 药学实践与服务, 2024, 42(11): 479-486. doi: 10.12206/j.issn.2097-2024.202401073
[5]	陈金涛, 乔子婴, 马明华, 张若曦, 王振伟, 年华. 基于网络药理学和分子对接技术研究金芪清疏颗粒治疗社区获得性肺炎的潜在机制 . 药学实践与服务, 2024, 42(11): 471-478. doi: 10.12206/j.issn.2097-2024.202312014
[6]	徐璐璐, 刘爱军. 丹参白术方“异病同治”冠心病、血管性痴呆、特发性膜性肾病的网络药理学作用机制研究 . 药学实践与服务, 2024, 42(12): 1-8. doi: 10.12206/j.issn.2097-2024.202312027
[7]	冯志惠, 邓仪卿, 叶冰, 安培, 张宏, 张海军. 雀梅藤石油醚提取物诱导三阴性乳腺癌细胞凋亡的实验研究 . 药学实践与服务, 2024, 42(6): 253-259. doi: 10.12206/j.issn.2097-2024.202311055
[8]	景凯, 杨慈荣, 张圳, 臧艺蓓, 刘霞. 黄芪甲苷衍生物治疗慢性心力衰竭小鼠的药效评价及作用机制研究 . 药学实践与服务, 2024, 42(5): 190-197. doi: 10.12206/j.issn.2097-2024.202310004
[9]	姜涛, 徐卫凡, 蒋益萍, 夏天爽, 辛海量. 巴戟天丸组方对Aβ损伤成骨细胞的作用及基于网络药理学的机制研究 . 药学实践与服务, 2024, 42(7): 285-290, 296. doi: 10.12206/j.issn.2097-2024.202305011
[10]	杨念, 张博乐, 张俊霞, 张振强. 一种中药组合物对ANIT诱导的小鼠胆汁淤积肝损伤的保护作用研究 . 药学实践与服务, 2024, 42(12): 508-511, 519. doi: 10.12206/j.issn.2097-2024.202305008
[11]	张成中, 朱雪艳, 卜其涛, 王宏瑞, 黄宝康. 基于网络药理学与分子对接预测鸡骨草特征图谱研究 . 药学实践与服务, 2024, 42(8): 350-358. doi: 10.12206/j.issn.2097-2024.202303048
[12]	陈怡君, 王卓, 何苗, 张宇, 田泾. 泌尿系统碎石术抗菌药物预防使用合理管控实践 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202402034

点击查看大图

计量

文章访问数: 2902
HTML全文浏览量: 253
PDF下载量: 443
被引次数: 0

消化系统毒理学生物标志物研究新进展

第二军医大学新药评价中心,上海 200433

基金项目: "重大新药创制"科技重大专项 (2008ZXJ09014-0095, 2009ZX09301-011).

收稿日期: 2010-10-13
修回日期: 2010-12-02

关键词:

生物标志物 /

消化系统 /

毒理学

摘要: 毒理学生物标志物是机体对化学物质毒性剂量暴露后的生物学变化,可特异性地反映毒性效应。对毒理学生物标志物进行全面评估,并尽快应用于临床,可以有效地减少药物研发风险。新近发现与消化系统毒理学研究有关的生物标志物有肠脂肪酸结合蛋白、二胺氧化酶、牛磺酸、山梨醇脱氢酶、羧酸酯酶-2、转化生长因子β1、组织多肽特异性抗原、再生基因蛋白Reg4、S100蛋白、血清糖蛋白YKL-40等。