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赤芍(Paeoniae Radix Rubra)为毛莨科植物芍药(Paeonia lactiflora Pall)或川赤芍(Paeonia veitchii Lynch)的干燥根,应用历史悠久,首载于《神农本草经》。赤芍之名最早在南北朝时期陶弘景所撰写的《本草经集注》中明确提出[1];其味苦,性微寒,归肝经,具有清热凉血、散瘀止痛、活血之功效,多用于热入营血,血热吐衄,斑疹紫暗,温毒发斑,热毒血瘀,肝郁肋痛等证[2-4]。
现代药理研究表明,赤芍作用广泛,主要含有赤芍苷、黄酮类及其苷、有机酸、挥发油及糖类等多种化学成分。本文就赤芍药理作用的研究进展进行综述,梳理赤芍已明确的药理作用及机制,为赤芍的进一步开发研究和临床应用提供科学依据。
Review of pharmacological effects of Paeoniae Radix Rubra
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摘要: 赤芍具有清热凉血、散瘀止痛的功效。赤芍及其有效成分在保肝、抗肿瘤、保护神经与心脏等方面有着显著的药理作用。通过查阅近年国内外的相关文献发现,赤芍的研究大多集中在作用机制、药物研发及临床应用方面。本文综述赤芍及其有效成分的药理作用研究进展,以期对赤芍的研究和临床应用提供有益的参考。Abstract: Paeoniae Radix Rubra has the effects of clearing heat, cooling blood, dissipating blood stasis and pain relieving (in terms of Chinese medicine). Paeoniae Radix Rubra and its active ingredients have significant pharmacological effects in anti-tumor, protecting liver, nerve and heart. By reviewing the relevant literatures published in recent years, we found that the studies on Paeoniae Radix Rubra are mainly focused in the mechanism of action, drug development and clinical application. In this review, we summarize the research results of the pharmacological effects of Paeoniae Radix Rubra and its active ingredients in order to provide the reference for the future research and clinical application of Paeoniae Radix Rubra.
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Key words:
- Paeoniae Radix Rubra /
- chemical composition /
- pharmacologic action
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