脂解模型在脂质给药系统体外评价中的应用研究进展

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脂解模型在脂质给药系统体外评价中的应用研究进展

曾棋平, 张晶, 刘志宏, 宋洪涛

文章导航 > 药学实践与服务 > 2014 > 32(2): 85-87

曾棋平, 张晶, 刘志宏, 宋洪涛. 脂解模型在脂质给药系统体外评价中的应用研究进展[J]. 药学实践与服务, 2014, 32(2): 85-87. doi: 10.3969/j.issn.1006-0111.2014.02.002

引用本文:

曾棋平, 张晶, 刘志宏, 宋洪涛. 脂解模型在脂质给药系统体外评价中的应用研究进展[J]. 药学实践与服务, 2014, 32(2): 85-87. doi: 10.3969/j.issn.1006-0111.2014.02.002

ZENG Qiping, ZHANG Jing, LIU Zhihong, SONG Hongtao. In vitro evaluation of lipid drug delivery system by lipolysis model[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 85-87. doi: 10.3969/j.issn.1006-0111.2014.02.002

Citation:

ZENG Qiping, ZHANG Jing, LIU Zhihong, SONG Hongtao. In vitro evaluation of lipid drug delivery system by lipolysis model[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 85-87. doi: 10.3969/j.issn.1006-0111.2014.02.002

脂解模型在脂质给药系统体外评价中的应用研究进展

doi: 10.3969/j.issn.1006-0111.2014.02.002

1.
南京军区福州总医院药学科, 福建福州 350025;福建医科大学药学院, 福建福州 350108
2.
南京军区福州总医院药学科, 福建福州 350025

基金项目: 福建省自然科学基金(2010J01218).

In vitro evaluation of lipid drug delivery system by lipolysis model

1.
Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China;School of Pharmacy, Fujian Medical University, Fuzhou 350108, China
2.
Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China

摘要: 目的综述脂解模型的组成及其在脂质制剂体外评价的应用,为推动脂质制剂的发展提供参考。方法通过查阅近年来国内外相关文献,归纳、分析和总结。结果体外脂解模型能准确反映脂质制剂在人体内的性质,建立良好的体内外相关性。结论脂解模型用于筛选和评价脂质制剂具有良好的应用前景。
- 脂解模型 /
- 脂质制剂 /
- 体内外相关性 /
- 筛选
Abstract: Objective To review the composition of lipolysis model and the application in the in vitro evaluation of lipid formulations, provide reference for promoting the development of lipid formulations. Methods Recent relevant literatures were analyzed and summarized. Results In vitro lipolysis model could accurately reflect the in vivo nature of lipid formulations, and a good correlation between in vivo and in vitro could be established. Conclusion There is a good prospect in using lipolysis model for screening and evaluation of lipid formulations.
- lipolysis model /
- lipid formulations /
- in vitro-in vivo correlation /
- screening

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脂解模型在脂质给药系统体外评价中的应用研究进展

doi: 10.3969/j.issn.1006-0111.2014.02.002

1. 南京军区福州总医院药学科, 福建福州 350025;福建医科大学药学院, 福建福州 350108

2. 南京军区福州总医院药学科, 福建福州 350025

基金项目: 福建省自然科学基金(2010J01218).

收稿日期: 2013-04-25
修回日期: 2013-11-04

关键词:

体内外相关性 /

摘要: 目的综述脂解模型的组成及其在脂质制剂体外评价的应用,为推动脂质制剂的发展提供参考。方法通过查阅近年来国内外相关文献,归纳、分析和总结。结果体外脂解模型能准确反映脂质制剂在人体内的性质,建立良好的体内外相关性。结论脂解模型用于筛选和评价脂质制剂具有良好的应用前景。

English Abstract

曾棋平, 张晶, 刘志宏, 宋洪涛. 脂解模型在脂质给药系统体外评价中的应用研究进展[J]. 药学实践与服务, 2014, 32(2): 85-87. doi: 10.3969/j.issn.1006-0111.2014.02.002

引用本文:

曾棋平, 张晶, 刘志宏, 宋洪涛. 脂解模型在脂质给药系统体外评价中的应用研究进展[J]. 药学实践与服务, 2014, 32(2): 85-87. doi: 10.3969/j.issn.1006-0111.2014.02.002

ZENG Qiping, ZHANG Jing, LIU Zhihong, SONG Hongtao. In vitro evaluation of lipid drug delivery system by lipolysis model[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 85-87. doi: 10.3969/j.issn.1006-0111.2014.02.002

Citation:

ZENG Qiping, ZHANG Jing, LIU Zhihong, SONG Hongtao. In vitro evaluation of lipid drug delivery system by lipolysis model[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 85-87. doi: 10.3969/j.issn.1006-0111.2014.02.002

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