苦参碱衍生物抗关节炎作用研究

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苦参碱衍生物抗关节炎作用研究

解方园, 王甜甜, 许维恒, 辛宝, 周许薇, 张国庆

文章导航 > 药学实践与服务 > 2019 > 37(3): 241-245

解方园, 王甜甜, 许维恒, 辛宝, 周许薇, 张国庆. 苦参碱衍生物抗关节炎作用研究[J]. 药学实践与服务, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

引用本文:

解方园, 王甜甜, 许维恒, 辛宝, 周许薇, 张国庆. 苦参碱衍生物抗关节炎作用研究[J]. 药学实践与服务, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

XIE Fangyuan, WANG Tiantian, XU Weiheng, XIN Bao, ZHOU Xuwei, ZHANG Guoqing. Anti-arthritis effects of matrine derivative in rats[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

Citation:

XIE Fangyuan, WANG Tiantian, XU Weiheng, XIN Bao, ZHOU Xuwei, ZHANG Guoqing. Anti-arthritis effects of matrine derivative in rats[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

苦参碱衍生物抗关节炎作用研究

doi: 10.3969/j.issn.1006-0111.2019.03.010

1.
海军军医大学附属东方肝胆外科医院药材科, 上海 200438
2.
海军军医大学药学院生化药学教研室, 上海 200433

Anti-arthritis effects of matrine derivative in rats

1.
Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical University, Shanghai 200438, China
2.
Department of Microbiology and Biochemical Pharmacy, School of Pharmacy, Naval Medical University, Shanghai 200433, China

摘要: 目的研究苦参碱衍生物M19对二型胶原诱导性大鼠关节炎（CIA）的治疗作用。方法将60只大鼠随机分为6组，分别为空白组，模型组，吲哚美辛治疗组，M19低、中、高剂量（2.5、5、10 mg/kg）组。采用二型胶原诱导建立关节炎模型，分别对大鼠足趾肿胀和体重进行测定并对关节炎进行评分，HE染色观察大鼠关节软骨及滑膜组织病理变化，Micro-CT观察大鼠骨关节组织损伤情况。结果苦参碱衍生物M19各剂量组均能不同程度降低大鼠关节炎足趾肿胀程度，增加体重，抑制大鼠关节炎性细胞浸润和滑膜增生，并对骨组织具有一定的保护作用。结论苦参碱衍生物M19对二型胶原诱导的关节炎具有一定的治疗作用。
- 苦参碱衍生物 /
- 类风湿性关节炎 /
- 二型胶原 /
- 大鼠
Abstract: Objective To study the therapeutic effects of matrine derivative M19 on type Ⅱcollagen-induced arthritis (CIA) in rats. Methods Sixty rats were randomly divided into six groups:blank group,model group,indomethacin treatment group,M19 low,medium and high dose groups (2.5,5,10 mg/kg).The paw swelling,arthritis index (AI) and body weight were measured for CIA rats.The histopathological changes of joints and synovial tissue were observed by HE staining.The bone destruction was observed with micro-CT. Results Matrine derivative M19 reduced the paw swelling,increased body weight,inhibited inflammatory cell infiltration,ameliorated synovial tissue and bone destruction in CIA rats. Conclusion Matrine derivative M19 has the certain therapeutic effects on CIA.
- matrine derivative /
- rheumatoid arthritis /
- typeⅡcollagen /
- rats

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苦参碱衍生物抗关节炎作用研究

doi: 10.3969/j.issn.1006-0111.2019.03.010

1. 海军军医大学附属东方肝胆外科医院药材科, 上海 200438

2. 海军军医大学药学院生化药学教研室, 上海 200433

收稿日期: 2018-11-08
修回日期: 2018-12-19

关键词:

苦参碱衍生物 /

类风湿性关节炎 /

摘要: 目的研究苦参碱衍生物M19对二型胶原诱导性大鼠关节炎（CIA）的治疗作用。方法将60只大鼠随机分为6组，分别为空白组，模型组，吲哚美辛治疗组，M19低、中、高剂量（2.5、5、10 mg/kg）组。采用二型胶原诱导建立关节炎模型，分别对大鼠足趾肿胀和体重进行测定并对关节炎进行评分，HE染色观察大鼠关节软骨及滑膜组织病理变化，Micro-CT观察大鼠骨关节组织损伤情况。结果苦参碱衍生物M19各剂量组均能不同程度降低大鼠关节炎足趾肿胀程度，增加体重，抑制大鼠关节炎性细胞浸润和滑膜增生，并对骨组织具有一定的保护作用。结论苦参碱衍生物M19对二型胶原诱导的关节炎具有一定的治疗作用。

English Abstract

解方园, 王甜甜, 许维恒, 辛宝, 周许薇, 张国庆. 苦参碱衍生物抗关节炎作用研究[J]. 药学实践与服务, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

引用本文:

解方园, 王甜甜, 许维恒, 辛宝, 周许薇, 张国庆. 苦参碱衍生物抗关节炎作用研究[J]. 药学实践与服务, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

XIE Fangyuan, WANG Tiantian, XU Weiheng, XIN Bao, ZHOU Xuwei, ZHANG Guoqing. Anti-arthritis effects of matrine derivative in rats[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

Citation:

XIE Fangyuan, WANG Tiantian, XU Weiheng, XIN Bao, ZHOU Xuwei, ZHANG Guoqing. Anti-arthritis effects of matrine derivative in rats[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

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