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肝脏是人体内重要的实质器官,在新陈代谢、排毒和天然免疫中发挥关键作用[1-2]。酒精、药物、病毒等是肝损伤的暴露因素,在这些损伤因素的作用下,肝细胞易发生坏死进而导致肝损伤。肝损伤过程中会引发炎症,持续的肝脏炎症将导致肝纤维化,肝纤维化的持续发展将转变为肝硬化,甚至发展为肝癌。信号转导和转录激活因子3(signal transduction and transcriptional activator 3,STAT3)是体内重要的转录因子,在细胞生长、增殖和分化等生物过程中发挥关键作用。研究发现,STAT3的激活与肝损伤、炎症、肝再生、肝纤维化甚至肝癌密切相关。本文综述了STAT3在不同肝病中的研究进展,并讨论了STAT3抑制剂在治疗肝病中的潜在应用前景。
Research progress of STAT3 on liver disease
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摘要: 信号转导和转录激活因子3(STAT3)是一种重要的转录因子,可被多种细胞因子和生长因子激活,在细胞生长、增殖和分化中发挥关键作用。研究表明,几乎所有的人类肝脏疾病和肝损伤动物模型中均存在STAT3过度激活的现象。通过抑制STAT3的激活可治疗急性肝损伤和肝纤维化,故STAT3抑制剂具有预防和治疗肝脏疾病的潜力。针对STAT3在肝损伤、肝炎、肝再生、肝纤维化和肝癌发生方面的研究进展作一综述。Abstract: Signal transduction and transcriptional activator 3 (STAT3) is an important transcription factor that can be activated by many cytokines and growth factors. STAT3 plays a key role in cell growth, proliferation, and differentiation. It has been shown that hyperactivation of STAT3 exists in almost all animal models of liver injury and human liver diseases. Therefore, inhibition of STAT3 activation might become a promising strategy for prevention and treatment of acute liver injury and liver fibrosis. The research progress of STAT3 on liver injury, hepatitis, liver regeneration, liver fibrosis, and hepatocellular carcinoma were mainly discussed in this review.
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Key words:
- STAT3 /
- liver injury /
- liver fibrosis /
- hepatocellular carcinoma
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