炎症小体与中枢神经系统疾病

杜秀明; 张子腾; 宗英; 余琛琳; 张晓冬; 陆国才

doi:10.3969/j.issn.1006-0111.2016.01.004

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

炎症小体与中枢神经系统疾病

杜秀明, 张子腾, 宗英, 余琛琳, 张晓冬, 陆国才

文章导航 > 药学实践与服务 > 2016 > 34(1): 12-15

杜秀明, 张子腾, 宗英, 余琛琳, 张晓冬, 陆国才. 炎症小体与中枢神经系统疾病[J]. 药学实践与服务, 2016, 34(1): 12-15. doi: 10.3969/j.issn.1006-0111.2016.01.004

引用本文:

杜秀明, 张子腾, 宗英, 余琛琳, 张晓冬, 陆国才. 炎症小体与中枢神经系统疾病[J]. 药学实践与服务, 2016, 34(1): 12-15. doi: 10.3969/j.issn.1006-0111.2016.01.004

DU Xiuming, ZHANG Ziteng, ZONG Ying, YU Chenlin, ZHANG Xiaodong, LU Guocai. Inflammasome and diseases of central nervous system[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 12-15. doi: 10.3969/j.issn.1006-0111.2016.01.004

Citation:

DU Xiuming, ZHANG Ziteng, ZONG Ying, YU Chenlin, ZHANG Xiaodong, LU Guocai. Inflammasome and diseases of central nervous system[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 12-15. doi: 10.3969/j.issn.1006-0111.2016.01.004

炎症小体与中枢神经系统疾病

doi: 10.3969/j.issn.1006-0111.2016.01.004

第二军医大学卫生毒理学教研室, 上海 200433

基金项目: "重大新药创制"科技重大专项(2014ZX09J14106);国家自然科学基金(81473291、81402651);上海市自然科学基金(13ZR144940);上海市公共卫生重点实验室建设计划(12GWZX0501)

Inflammasome and diseases of central nervous system

Department of Health Toxicology, Second Military Medical University, Shanghai 200433, China

摘要: 炎症小体是一蛋白复合物,能够识别不同刺激信号,活化后能诱导免疫和炎症应答。NLRP3炎症小体是中枢神经系统中研究最广泛的炎症小体。小胶质细胞、血管周围的巨噬细胞和脑膜巨噬细胞均能表达炎症小体,而炎症小体与急性脑部感染、急性无菌性脑损伤、帕金森病和阿尔茨海默病等的发生发展有密切关系。基于炎症小体与中枢神经系统疾病相关的机制探索和靶向药物开发是目前的研究热点。
- 炎症小体 /
- 中枢神经系统 /
- 小胶质细胞 /
- 巨噬细胞 /
- 帕金森病 /
- 阿尔茨海默病
Abstract: Inflammasome is the body of protein complex which is able to identify different stimulation signals and can induce immune and inflammatory responses when it is activated. NLRP3 inflammasome has been extensively studied in the central nervous system. Microglia, perivascular macrophages and meningeal macrophages express inflammasomes. The occurrence and development of acute brain infection, aseptic acute brain injury, Parkinson disease and Alzheimer disease are closely related to inflammasomes. Based on mechanisms exploration of the inflammasome's role in the central nervous system disorders, its target drug research and development will be greatly addressed in the future.
- inflammasome /
- the central nervous system /
- microglia /
- macrophages /
- Parkinson disease /
- Alzheimer disease

[1]	de Rivero Vaccari JP,Dietrich WD,Keane RW. Activation and regulation of cellular inflammasomes: gaps in our knowledge for central nervous system injury[J]. J Cereb Blood Flow Metab, 2014, 34(3):369-375.
[2]	Heneka MT, Kummer MP, Andrea Stutz, et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice[J]. Nature, 2013, 493(7434):674-678.
[3]	Weber MD, Frank MG, Tracey KJ, et al. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome[J]. J Neurosci, 2015, 35(1):316-324.
[4]	Ying P, Yang CX, Yu ZQ, et al. Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats[J]. Brain Behav Immun, 2014, 41:90-100.
[5]	Cribbs DH, Berchtold NC, Perreau V, et al. Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study[J]. J Neuroinflammation, 2012, 9:179-196.
[6]	Shao BZ, Wei W, Ke P, et al. Activating cannabinoid receptor 2 alleviates pathogenesis of experimental autoimmune encephalomyelitis via activation of autophagy and Inhibiting NLRP3 inflammasome[J]. CNS Neurosci Ther, 2014, 20(12):1021-1028.
[7]	Weber MD, Frank MG, Tracey KJ, et al. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome[J]. J Neurosci, 2015, 35:316-324.
[8]	Walsh JG,Muruve DA,Paver C.Inflammasomes in the CNS[J].Nat Rev Neurosci,2014,15(2):84-97.
[9]	Kumar M, Roe K,Orillo B, et al. Inflammasome adaptor protein apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in West Nile virus encephalitis[J]. Virol, 2013, 87:3655-3667.
[10]	Hoegen T, Tremel N,, et al. The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release[J]. J Immunol, 2011, 187:5440-5451.
[11]	Pradillo JM, Denes A, Greenhalgh AD, et al. Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats[J]. J Cereb Blood Flow Metab, 2012, 32:1810-1819.
[12]	Lupfer C, Kanneganti TD. Unsolved Mysteries in NLR Biology[J]. Front Immunol, 2013, 4:285-294.
[13]	Richter K, Kiefer KP, Grzesik BA, et al. Hydrostatic pressure activates ATP-sensitive K⁺ channels in lung epithelium by ATP release through pannexin and connexin hemichannels[J]. FASEB J, 2014, 28(1):45-55.
[14]	Kampen JMV, Baranowski D, Kay DG. Progranulin gene delivery protects dopaminergic neurons in a mouse model of Parkinson's disease[J]. PLoS One, 2014, 9(5):e97032.
[15]	Codolo G, Plotegher N, Pozzobon T, et al. Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies[J]. PLoS One,2013,8(1):e55375.
[16]	Lu M, Sun XL, Qiao C, et al. Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation[J]. Neurobiology Aging, 2014, 35:421-430.
[17]	Guillot-Sestier MV, Town T. Innate immunity in Alzheimer's disease: a complex affair[J]. CNS Neurol Disord Drug Targets, 2013, 12:593-607.
[18]	Halle A,Hornung V,Petzold GC,et al. The NALP3 inflammassome is involved in the innate immune reponse to amyloid-beta[J].Nat Immunol,2008,9(8):857-865.
[19]	Tan Ms,Yu JT,Jiang T,et al.The NLRP3 inflammasome in Alzheimer's disease[J].Mol Neurobiol,2013,84(3):875-82.

[1]	陈怡君, 王卓, 何苗, 张宇, 田泾. 泌尿系统碎石术抗菌药物预防使用合理管控实践 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202402034
[2]	刘汝雄, 杨万镇, 涂杰, 盛春泉. 铁死亡调控蛋白GPX4的小分子抑制剂研究进展 . 药学实践与服务, 2024, 42(9): 375-378. doi: 10.12206/j.issn.2097-2024.202312075
[3]	陈静, 何瑞华, 翁月, 徐熠, 刘静, 黄瑾. 基于网络药理学和分子对接技术探究定清片活性成分治疗白血病的作用机制 . 药学实践与服务, 2024, 42(11): 1-8. doi: 10.12206/j.issn.2097-2024.202401073
[4]	迟文雅, 袁艳, 李伟林, 吴茼妤, 俞媛. 负载骨髓间充质干细胞/白藜芦醇脂质体的水凝胶支架用于创伤性脑损伤治疗 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202406034
[5]	冯志惠, 邓仪卿, 叶冰, 安培, 张宏, 张海军. 雀梅藤石油醚提取物诱导三阴性乳腺癌细胞凋亡的实验研究 . 药学实践与服务, 2024, 42(6): 253-259. doi: 10.12206/j.issn.2097-2024.202311055
[6]	修建平, 杨朝爱, 刘禧澳, 潘乾禹, 韦广旭, 王卫星. 全反式维甲酸对肝星状细胞活化及氧化应激的作用和机制探索 . 药学实践与服务, 2024, 42(7): 291-296. doi: 10.12206/j.issn.2097-2024.202312054
[7]	姜涛, 徐卫凡, 蒋益萍, 夏天爽, 辛海量. 巴戟天丸组方对Aβ损伤成骨细胞的作用及基于网络药理学的机制研究 . 药学实践与服务, 2024, 42(7): 285-290, 296. doi: 10.12206/j.issn.2097-2024.202305011
[8]	杨媛媛, 安晓强, 许佳捷, 江键, 梁媛媛. 正极性驻极体联合5-氟尿嘧啶对瘢痕成纤维细胞生长抑制的协同作用 . 药学实践与服务, 2024, 42(6): 244-247. doi: 10.12206/j.issn.2097-2024.202310027
[9]	徐飞, 陈瑾, 鲁育含, 李志勇. 肠道菌群参与糖尿病肾病的机制研究进展 . 药学实践与服务, 2024, 42(5): 181-184, 197. doi: 10.12206/j.issn.2097-2024.202312023
[10]	刘丽艳, 余小翠, 孙传铎. 纳武利尤单抗治疗非小细胞肺癌有效性及安全性的Meta分析 . 药学实践与服务, 2024, 42(10): 451-456. doi: 10.12206/j.issn.2097-2024.202310044
[11]	宋雨桐, 夏德润, 顾珩, 唐少文, 易洪刚, 沃红梅. 帕博利珠单抗与铂类化疗方案在晚期非小细胞肺癌一线治疗中的药物经济学评价 . 药学实践与服务, 2024, 42(8): 334-340. doi: 10.12206/j.issn.2097-2024.202303023
[12]	岳春华, 贲永光, 王海桥. 基于NLRP1炎症小体探讨百合知母汤抗抑郁的作用机制 . 药学实践与服务, 2024, 42(8): 325-333. doi: 10.12206/j.issn.2097-2024.202401033

点击查看大图

计量

文章访问数: 3502
HTML全文浏览量: 352
PDF下载量: 130
被引次数: 0

炎症小体与中枢神经系统疾病

doi: 10.3969/j.issn.1006-0111.2016.01.004

第二军医大学卫生毒理学教研室, 上海 200433

收稿日期: 2015-07-09
修回日期: 2015-10-15

关键词:

摘要: 炎症小体是一蛋白复合物,能够识别不同刺激信号,活化后能诱导免疫和炎症应答。NLRP3炎症小体是中枢神经系统中研究最广泛的炎症小体。小胶质细胞、血管周围的巨噬细胞和脑膜巨噬细胞均能表达炎症小体,而炎症小体与急性脑部感染、急性无菌性脑损伤、帕金森病和阿尔茨海默病等的发生发展有密切关系。基于炎症小体与中枢神经系统疾病相关的机制探索和靶向药物开发是目前的研究热点。