维生素D受体基因的多态性与检测方法

游春华; 熊筱娟; 王清华; 陈万生; 高守红

doi:10.3969/j.issn.1006-0111.2014.05.003

维生素D受体基因的多态性与检测方法

doi: 10.3969/j.issn.1006-0111.2014.05.003

1.
第二军医大学附属长征医院药学部, 上海 200003;宜春学院化学与生物工程学院, 江西宜春 336000
2.
宜春学院化学与生物工程学院, 江西宜春 336000
3.
第二军医大学附属长征医院药学部, 上海 200003

Study on receptor gene polymorphism and detection method of vitamin D

1.
Department of Pharmacy, Changzheng Hospital Affiliated to Second Military Medical University, Shanghai 200433, China;Yichun University, College of Chemistry and Bio-engineering, Yichun 336000, China
2.
Yichun University, College of Chemistry and Bio-engineering, Yichun 336000, China
3.
Department of Pharmacy, Changzheng Hospital Affiliated to Second Military Medical University, Shanghai 200433, China

摘要: 近年研究发现,维生素D缺乏除与骨软化相关外,还与高血压、糖尿病、代谢综合征等多种疾病相关。维生素D在体内经肝脏和肾脏两次羟基化后作用于其受体而发挥生理作用。笔者通过查阅国内外相关文献,介绍维生素D与疾病的关系及维生素 D受体基因多态性研究现状,阐述检测维生素D常用方法的优缺点,提出检测维生素D的最佳方法及其受体基因多态性检测的重要性,从而指导临床医生合理用药。
- 维生素D /
- 基因多态性 /
- 维生素D受体 /
- 合理用药
Abstract: In recent years, many studies have found that vitamin D insufficiency is associated with osteomalacia, hypertension, diabetes, metabolic syndrome and other diseases. Vitamin D must be hydroxylated in the liver by a 25-hydroxylase for the first time, and then in the kidney by a 1α-hydroxylase for the second time to form the active metabolite 1, 25-dihydroxy vitamin D, which binds to the intracellular vitamin D receptor and exerts its effects. This paper reviewed the relationship between vitamin D and disease, present research situation of gene polymorphism of vitamin D receptor, and the advantages and limitations of several methods of vitamin D detection, and proposed the best method for detecting vitamin D receptor gene polymorphism and the importance of the detection state to guide clinicians to use drug rationally.
- vitamin D /
- gene polymorphism /
- vitamin D receptor /
- rational drug use

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维生素D受体基因的多态性与检测方法

doi: 10.3969/j.issn.1006-0111.2014.05.003

Study on receptor gene polymorphism and detection method of vitamin D

计量

维生素D受体基因的多态性与检测方法

doi: 10.3969/j.issn.1006-0111.2014.05.003

1. 第二军医大学附属长征医院药学部, 上海 200003;宜春学院化学与生物工程学院, 江西宜春 336000

2. 宜春学院化学与生物工程学院, 江西宜春 336000

3. 第二军医大学附属长征医院药学部, 上海 200003

English Abstract

Study on receptor gene polymorphism and detection method of vitamin D

全文HTML

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留言板

维生素D受体基因的多态性与检测方法

doi: 10.3969/j.issn.1006-0111.2014.05.003

Study on receptor gene polymorphism and detection method of vitamin D

计量

出版历程

维生素D受体基因的多态性与检测方法

doi: 10.3969/j.issn.1006-0111.2014.05.003

1. 第二军医大学附属长征医院药学部, 上海 200003;宜春学院化学与生物工程学院, 江西 宜春 336000 2. 宜春学院化学与生物工程学院, 江西 宜春 336000 3. 第二军医大学附属长征医院药学部, 上海 200003

English Abstract

Study on receptor gene polymorphism and detection method of vitamin D

全文HTML

目录

1. 第二军医大学附属长征医院药学部, 上海 200003;宜春学院化学与生物工程学院, 江西宜春 336000

2. 宜春学院化学与生物工程学院, 江西宜春 336000

3. 第二军医大学附属长征医院药学部, 上海 200003