中药复方药动学研究方法概述

彭成成; 金慧子; 柳润辉

doi:10.3969/j.issn.1006-0111.2015.01.002

中药复方药动学研究方法概述

doi: 10.3969/j.issn.1006-0111.2015.01.002

1.
上海交通大学药学院, 上海 200240
2.
第二军医大学药学院天然药物化学教研室, 上海 200433

Summary of the pharmacokinetic methods of traditional Chinese medicine prescription

1.
School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China
2.
Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 概述中药复方药动学研究的几种方法,包括生物效应法、血药浓度法、中药复方多效应成分整合药动学及中药复方药动学-药效学结合模型,阐明各自的特征及优缺点,并对中药复方药动学研究方法的发展进行总结和展望。
- 中药复方 /
- 药动学 /
- 研究方法
Abstract: This review made a brief summary of several pharmacokinetic methods of traditional Chinese medicine (TCM) prescription including the methods of biological effects,plasma concentration,integrated Pharmacokinetics of multiple effective components of TCM prescription and integrated pharmacokinetic-pharmacodynamic of TCM prescription.The corresponding characteristics,advantages and disadvantages of each of these methods were analyzed.And the progresses of the pharmacokinetic methods of TCM prescription were concluded and prospected.
- traditional Chinese medicine (TCM) prescription /
- pharmacokinetics /
- research methods

[1]	郝福,蒋晔,李艳荣,等.复方中药化学成分的研究进展[J].中成药,2007,29(2):258-262.
[2]	梁文权.生物药剂学与药物动力学[M].3版.北京:人民卫生出版社,2007:169-171.
[3]	Smolen VF,Barile RG,Theophanous TG.Relationship between dose,effect,time and biophasic drug levels[J].J Pharm Sci,1972,61 (3):467-470.
[4]	肇丽梅,何晓静,邱枫.药理效应法测定黄芩苷及清热合剂的药动学参数[J].广东药学院学报,2006,22(1):22-24.
[5]	赫梅生,詹丽芬,郭景阳,等.用动物急性死亡率估计药物体存率与表观半衰期[J].中国药理学报,1985,6(3):213-216.
[6]	马昕.浅谈中药复方的药代动力学[J].北方药学,2011,8(11):18-19.
[7]	刘萍,黄颖.中药复方的药代动力学研究方法和存在的若干问题[J].湖北中医学院学报,2010,12(6):64-66.
[8]	黄衍民,潘留华,吴晓放,等.乌头注射液对小鼠的毒效动力学研究[J].中国药学,1998,33(7):421-423.
[9]	周丽娟,许利平,陈慧娟,等,中药复方药代动力学常用研究方法评价[J].中华中医药学刊,2007,25(5):1041-1043.
[10]	向大雄,李焕德,胥新元.中药复方药代动力学研究概况[J].中国实验方剂学杂志,2002,8(1):61-63.
[11]	Wei H,Xu W,Cai F,et al.Simultaneous determination of five lignin constituents of Wuzhi capsule in rat plasma by LC-MS/MS:application to pharmacokinetic study[J].J Pharm Biomed Anal,2010,52 (5):741-746.
[12]	Liu P,Li ZH,Qian DW,et al.Simultaneous determination of bioactive components in essential oil of Xiang-Fu-Si-Wu formula in Beagle dog plasma by UPLC-MS/MS and its application to pharmacokinetics[J].J Chromatogr B,2013,929:63-69.
[13]	Cai F,Xu W,Wei H,et al.Simultaneous determination of active xanthone glycosides,timosaponins and alkaloids in rat plasma after oral administration of Zi-Shen Pill extract for the pharmacokinetic study by liquid chromatography-tandem mass spectrometry[J].J Chromatogr B,2010,878 (21):1845-1854.
[14]	Zuo F,Zhou ZM,Zhang Q,et al.Pharmacokinetic study on the multi-constituents of Huang Qin-Tang decoction in rats[J].Biol Pharm Bull,2003,26 (7):911-919.
[15]	谢跃生,张振清,阮金秀.六味地黄汤中马钱子素小鼠体内药代动力学研究[J].中草药,2002,33(9):817-819.
[16]	汤成泳,李卿,周远大,等.麝香滴眼液在家兔眼内组织中的分布及药代动力学研究[J].中成药,2010,32(4):581-585.
[17]	贺丰,罗佳波,陈飞龙,等.GC-MS法研究麻黄汤中麻黄碱、伪麻黄碱的人体内过程[J].中药新药与临床药理,2004,15(5):336-347.
[18]	Lu T,Liang Y,Song J,et al.Simultaneous determination of berberine and palmatine in rat plasma by HPLC-ESI-MS after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction and the pharmacokinetic application of the method[J].J Pharm Biomed Anal,2006,40 (5) :1218-1224.
[19]	Xia CH,Wang GJ,Sun JG,et al.Simultaneous determination of ginsenoside Rg1,Re,Rd,Rb1 and ophiopogonin D in rat plasma by liquid chromatography/electrosprayionization mass spectrometric method and its applicationto pharmacokinetic study of SHENMAI' injection[J].J Chromatogr B,2008,862 (1-2):72-78.
[20]	Zan B,Shi R,Wang TM,et al.Simultaneous quantification of multiple active components from Xiexin decoction in rat plasma by LC-ESI-MS/MS:application in pharmacokinetics[J].Biomed Chromatogr,2011,25 (7):816-826.
[21]	吕莉,孙慧君,韩国柱.中药药代动力学的研究进展[J].药学学报,2013,48(3):824-833.
[22]	张启云,徐良辉,李冰涛,等.复方葛根芩连汤多效应成分分类整合药代动力学研究[J].中国临床药理学与治疗学,2011,16(1):51-56.
[23]	Zhu HX,Qian ZL,Li H,et al.Integrated pharmacokinetics of major bioactive components in MCAO rats after oral administration of Huang-Lian-Jie-Du-Tang[J].J Ethnopharmacol,2012,141 (1):158-169.
[24]	李锐,晏亦林,周莉玲,等.四逆汤的药动学研究[J].中成药,2002,24(10):777-780.
[25]	田乐,狄留庆,周伟,等.中药多组分网络靶点效应PK-PD结合模型应用研究与思考[J].世界科学技术:中医药现代化,2012,14(4):1824-1830.
[26]	向铮,蔡小军,曾苏.基于复杂网络与代谢组学的中药药代动力学研究思考与探索[J].药学学报,2012,47(5):558-564.

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中药复方药动学研究方法概述

doi: 10.3969/j.issn.1006-0111.2015.01.002

Summary of the pharmacokinetic methods of traditional Chinese medicine prescription

计量

中药复方药动学研究方法概述

doi: 10.3969/j.issn.1006-0111.2015.01.002

1. 上海交通大学药学院, 上海 200240

2. 第二军医大学药学院天然药物化学教研室, 上海 200433

English Abstract

Summary of the pharmacokinetic methods of traditional Chinese medicine prescription

1. School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China

2. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

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留言板

中药复方药动学研究方法概述

doi: 10.3969/j.issn.1006-0111.2015.01.002

Summary of the pharmacokinetic methods of traditional Chinese medicine prescription

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出版历程

中药复方药动学研究方法概述

doi: 10.3969/j.issn.1006-0111.2015.01.002

1. 上海交通大学药学院, 上海 200240 2. 第二军医大学药学院天然药物化学教研室, 上海 200433

English Abstract

Summary of the pharmacokinetic methods of traditional Chinese medicine prescription

1. School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China 2. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

全文HTML

目录

1. 上海交通大学药学院, 上海 200240

2. 第二军医大学药学院天然药物化学教研室, 上海 200433

1. School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China

2. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China