吉西他滨对胰腺癌外周血调节性T细胞影响的研究

寇晓霞; 丁永梅; 黄耀; 袁振刚; 钱其军

doi:10.3969/j.issn.1006-0111.2015.03.018

吉西他滨对胰腺癌外周血调节性T细胞影响的研究

doi: 10.3969/j.issn.1006-0111.2015.03.018

东方肝胆外科医院生物治疗科, 上海 200438

基金项目: 第二军医大学青年启动基金课题(2012QN18)

Changes of regulatory T cells in peripheral blood after gemcitabine chemotherapy for pancreatic cancer patients

Department of Biotherapy, Eastern Hepatobiliary Surgical Hospital, Shanghai 200438, China

摘要: 目的探讨吉西他滨对胰腺癌外周血调节性T细胞的影响,为进一步提高过继免疫治疗的疗效提供依据和参考。方法本研究入选2012年1月至2014年10月收治的32例胰腺癌患者,分为吉西他滨组(吉西他滨+过继免疫治疗)和对照组(单纯过继免疫治疗),观察两组患者治疗前后外周血调节性T细胞水平、化疗不良反应,并对两组患者的生存时间进行分析比较。结果吉西他滨组患者治疗后外周血调节性T细胞水平较治疗前显著降低,与对照组相比亦显著降低,两组比较有统计学差异(P<0.05),吉西他滨组中位生存时间较对照组延长1.3个月(10.0个月与 8.7个月比较)。结论吉西他滨化疗可以显著降低胰腺癌患者外周血调节性T细胞水平,有效调节患者的肿瘤免疫耐受,提高过继免疫治疗的疗效。
- 吉西他滨 /
- 胰腺癌 /
- 调节性T细胞 /
- 过继免疫治疗
Abstract: Objective To investigate the influence of gemcitabine chemotherapy on levels of regulatory T cells(Tregs) in peripheral blood for patients with pancreatic cancer and provide evidence and reference for improving the efficacy of adoptive immunotherapy. Methods 32 patients were enrolled in this study from January 2012 to October 2014, among whom 16 received gemcitabine chemotherapy combined with adoptive immunotherapy(gemcitabine group), the other 16 patients received adoptive immunotherapy only(control group).The level of Tregs in peripheral blood, side effect and overall survival were observed before and after the therapy. Results The number of Tregs in peripheral blood was significantly decreased after gemcitabine chemotherapy, and it was also lower than that of the control group. The overall survival time of the gemcitabine group was 1.3 mo longer than the control group(10.0 mo vs 8.7 mo). Conclusion Therapeutic regimen of gemcitabine can remarkly deplete Tregs in peripheral blood of patients with pancreatic cancer, effectively regulate tumor immune tolerance, and improve the efficacy of adoptive immunotherapy.
- gemcitabine /
- pancreatic cancer /
- regulatory T cells(Tregs) /
- adoptive immunotherapy

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吉西他滨对胰腺癌外周血调节性T细胞影响的研究

doi: 10.3969/j.issn.1006-0111.2015.03.018

Changes of regulatory T cells in peripheral blood after gemcitabine chemotherapy for pancreatic cancer patients

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吉西他滨对胰腺癌外周血调节性T细胞影响的研究

doi: 10.3969/j.issn.1006-0111.2015.03.018

东方肝胆外科医院生物治疗科, 上海 200438

English Abstract

Changes of regulatory T cells in peripheral blood after gemcitabine chemotherapy for pancreatic cancer patients

Department of Biotherapy, Eastern Hepatobiliary Surgical Hospital, Shanghai 200438, China

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吉西他滨对胰腺癌外周血调节性T细胞影响的研究

doi: 10.3969/j.issn.1006-0111.2015.03.018

Changes of regulatory T cells in peripheral blood after gemcitabine chemotherapy for pancreatic cancer patients

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吉西他滨对胰腺癌外周血调节性T细胞影响的研究

doi: 10.3969/j.issn.1006-0111.2015.03.018

东方肝胆外科医院生物治疗科, 上海 200438

English Abstract

Changes of regulatory T cells in peripheral blood after gemcitabine chemotherapy for pancreatic cancer patients

Department of Biotherapy, Eastern Hepatobiliary Surgical Hospital, Shanghai 200438, China

全文HTML

目录