瑞香狼毒抗肿瘤作用
Antitumor activity of Chinese Stellese(Stellera chamaejasme L.)
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摘要: 瑞香狠毒水提物(ScL)抑制小鼠移植肿瘤S-180生长,5-20g/kg(相当生药)ip10d,抑制率为16.2-47.8%.ScL对体外培养的S-180细胞生长、集落形成和MTT甲化合物生成有显着抑制作用,并和剂量呈正相关。表明ScL的抗肿瘤作用是其直接作用于肿瘤细胞所产生。Abstract: Effects of Chinese Stellera(Stellera chamaejsme L. ScL)on the growth of mouse tumor S180 in vivo and in vitro were studied. It wsa found that ScL inhibited the growth of transplanted mouse tumor S180,5-20g/kg(equivalent crude drug)ip for 10d, the inhibition rates of it against S180 were 16.2-47.8%. ScL inhibited the proliferation,MTT formazan formation and clonal formatrion of S-180 celles. The inhibition rate had a positive interrelationship with the concentration and exposure time. These results showed that ScL had an effective antitumor activity in vitro and in vivo.
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Key words:
- Chinese Stellera(Stellera chamaejasme L.) /
- antitumor activity /
- S-180
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