聚乙烯醇衍生物作为水凝胶材料的应用研究进展

胡晓; 胡容峰; 白中稳

doi:10.3969/j.issn.1006-0111.2013.03.002

聚乙烯醇衍生物作为水凝胶材料的应用研究进展

doi: 10.3969/j.issn.1006-0111.2013.03.002

安徽中医学院, 安徽合肥 230031

Applied research of polyvinyl alcohol derivatives as hydrogel materials

Anhui University of Traditional Chinese Medicine, Hefei 230031, China

摘要: 目的介绍PVA衍生物作为水凝胶材料的应用研究进展,为进一步开发它提供依据和参考。方法参阅近年来国内外相关文献资料,对其进行综合、分析和归纳。结果 PVA水凝胶具有亲水性、柔软性、温和性和良好的生物相容性,其衍生物作为普通水凝胶和智能水凝胶材料被广泛应用于生物医药学领域。结论 PVA是一种极具再次开发潜力的优良药用辅料,具有很大的应用价值。
- 聚乙烯醇 /
- 衍生物 /
- 水凝胶 /
- 应用进展
Abstract: Objective To introduce the application research progress of PVA derivatives as hydrogel materials, and provide the basis and reference for further development. Methods The related documents at home and abroad in recent years were integrated, analyzed and summarized. Results PVA derivatives as conventional and sensitive hydrogel materials were widely used in the fields of biomedicine, having a hydrophilic, softness, mild characteristics and good biocompatibility. Conclusion PVA is an excellent pharmaceutical excipient for potential re-development, and having a great value.
- polyvinyl alcohol /
- derivatives /
- hydrogel /
- application progress

[1]	Sailaja GS,Sreenivasan K,Yokogawa Y,et al.Bioinspired mineralization andcell adhesion on surface functionalized PVA films[J].Acta Biomater,2009,5(5):1647.
[2]	Singh B,Sharma V.Design of psyllium-PVA-acrylic acid based novel hydrogels for use in antibiotic drug delivery[J].Int J Pharm,2010,389:94.
[3]	AL-Sabagh AM, Abdeen Z. Preparation and characterization of hydrogel based on PVA cross-linked by different cross-linkers used to dry organic solvents[J]. J Polym Environ,2010,18:576.
[4]	Otsuka E, Sugiyama M, Suzuki A. Formation and destruction of physical crosslinks by mild treatments in chemically crosslinked PVA gels[J].Polym Bull,2010,10:1007.
[5]	Wang JQ, Satoh M. Water properties in a novel thermoswelling PVA derivative hydrogel as studied by NMR and FTIR[J]. Langmuir, 2010, 26(16):13607.
[6]	Padavan DT,Hamilton AM,Millon LE,et al.Synthesis, characterization and in vitro cell compatibility study of a PAA graft/cross-linked PVA hydrogel[J]. ActaBiomaterialia,2011,7:258.
[7]	Alves MH,Young CJ,Bozzetto K,et al.Degradable,click PVA hydrogels:characterization of degradation and cellular compatibility[J]. Biomed Mater,2011,7:1.
[8]	Artyukhov AA,Shtilman MI,Kuskov AN,et al.Macroporous polymeric hydrogels formed from acrylate modified PVA macromers[J].Eur Polym J,2011,10(18):667.
[9]	Pan YS,Xiong DS,Gao F.Viscoelastic behavior of no-HA reinforced PVA gel biocomposites as an articular cartilage[J].J Mater Sci,2008,19:1963.
[10]	Cho SH,Lim SM,Han DK,et al.Time-dependent alginate/PVA hydrogels as injectable cell carriers[J].JBiomat Sci-Polym E,2009,20:863.
[11]	Negishi J,Nam KW,Kimura TS,et al.High-hydrostatic pressure technique is an effective method for the preparation of PVA-heparin hybridgel[J].Eur J Pharm Sci,2010,41:617.
[12]	Zan XJ,Kozlov M,McCarthy TJ,et al.Covalently attached, silver-doped PVA hydrogel films on Poly(L-lactic acid)[J].Biomacromolecules,2010,11:1082.
[13]	Abitbol T,Johnstone T,Quinn TM,et al.Reinforcement with cellulose nanocrystals of PVA hydrogels prepared by cyclic freezing and thawing[J].Soft Matter,2011,7:2373.
[14]	Bakhshandeh H,Soleimani M,Hosseini SS,et al.Poly (ε-caprolactone) nanofibrous ring surrounding a PVA hydrogel for the development of a biocompatible two-part artificial cornea[J].Int J Nanomed,2011,6:1509.
[15]	Sukhanova TV,Artyukhov AA,Prudchenko IA,et al.Entrapment and in vitro release of delta-sleep inducing peptide from polymer hydrogels based on modified PVA[J]. Biomedical Chemistry, 2012, 6(2):149.
[16]	姚女兆.果胶/PVA复合水凝胶人工髓核的实验研究[D].南方医科大学,2010.
[17]	Aboutaleb MF,Ismail SA,El-kelesh NA.Radiation synthesis and characterization of PVA/MAA-GEL hydrogel for vitro drug delivery[J].J Macromol Sci B,2009,46:170.
[18]	Wang B,Liu MZ,Chen ZB,et al.Preparation, characterization and controlled release investigation of interpenetrating polymer networks of PAA/triazole modified PVA[J].Int J Pharm,2007,331:19.
[19]	祝宝东,孟静,王鉴,等. PVA/淀粉接枝P(AA-AM)互穿网络水凝胶的合成与性能研究[J].科学技术与工程, 2011, 11(10):2234.
[20]	Qi BW,Yu AX,Zhu SB,et al.The preparation and cytocompatibility of injectable thermosensitive CS/PVA hydrogel[J].Med Sci,2010,30(1):89.
[21]	Tang YF,Du YM,Li Y,et al.A thermosensitive CS/PVA hydrogel containing hydroxyapatite for protein delivery[J].J Biomed Mater Res A, 2009, 91(4):953.
[22]	陈丽如. CS/PVA温敏性水凝胶给药系统的研究[D].河北大学,2011.
[23]	史林峰.PVA/AM接枝共聚物水凝胶的制备及表征[J].中国组织工程研究,2012,16(21):3919.
[24]	Zhang NY,Shen YG,Li XQ,et al.Synthesis and characterization of thermoand pH-sensitive PVA/poly(N,N-diethylacrylamide-co-itaconic acid) semi-IPN hydrogels[J].Biomed Mater,2012,7:1.

[1]	陈炳辰, 佟达丰, 万苗, 闫飞虎, 姚建忠. UPLC-MS/MS法测定小鼠血浆中紫杉醇脂肪酸酯前药及其药代动力学研究 . 药学实践与服务, 2024, 42(8): 341-345. doi: 10.12206/j.issn.2097-2024.202404082
[2]	李想, 陆鸿远, 张明玉, 高欢, 姚东, 许子华. 米格列醇激活UCP1介导棕色脂肪对冷暴露小鼠损伤的研究 . 药学实践与服务, 2024, 42(): 1-6. doi: 10.12206/j.issn.2097-2024.202404005
[3]	张艺昕, 关欣怡, 王博宁, 闻俊, 洪战英. 二氢吡啶类钙离子拮抗药物手性分析及其立体选择性药动学研究进展 . 药学实践与服务, 2024, 42(8): 319-324. doi: 10.12206/j.issn.2097-2024.202308062
[4]	陈炳辰, 王思真, 郭贝贝, 杨峰. 紫杉醇棕榈酸酯的合成及其脂质体的制备与处方研究 . 药学实践与服务, 2024, 42(9): 379-384, 410. doi: 10.12206/j.issn.2097-2024.202404062
[5]	崔亚玲, 吴琼, 马良煜, 胡北, 姚东, 许子华. 肝素钠肌醇烟酸酯乳膏中肌醇烟酸酯皮肤药动学研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404006
[6]	钱淑雨, 李铁军. 耐碳青霉烯类肠杆菌耐药机制的研究进展 . 药学实践与服务, 2024, 42(10): 419-425. doi: 10.12206/j.issn.2097-2024.202405005
[7]	刘汝雄, 杨万镇, 涂杰, 盛春泉. 铁死亡调控蛋白GPX4的小分子抑制剂研究进展 . 药学实践与服务, 2024, 42(9): 375-378. doi: 10.12206/j.issn.2097-2024.202312075
[8]	顾佳钰, 胡馨儿, 王晓飞, 张颖, 张海, 曹岩. 侧流免疫层析定量检测方法的研究进展 . 药学实践与服务, 2024, 42(7): 273-277, 284. doi: 10.12206/j.issn.2097-2024.202307037
[9]	王耀振, 徐灿, 吕顺莉, 田泾, 张东炜. 钾离子竞争性酸阻滞剂的药学特征研究进展 . 药学实践与服务, 2024, 42(7): 278-284. doi: 10.12206/j.issn.2097-2024.202306040
[10]	马兹芬, 许维恒, 金煜翔, 薛磊. 食管癌的靶向治疗与免疫治疗研究进展 . 药学实践与服务, 2024, 42(6): 231-237. doi: 10.12206/j.issn.2097-2024.202306008
[11]	徐飞, 陈瑾, 鲁育含, 李志勇. 肠道菌群参与糖尿病肾病的机制研究进展 . 药学实践与服务, 2024, 42(5): 181-184, 197. doi: 10.12206/j.issn.2097-2024.202312023
[12]	张广雨, 杜晶, 刘梦珍, 朱丹妮, 闫慧, 刘冲. 新斯的明与山莨菪碱联合应用对肺型氧中毒的保护作用及其机制的研究 . 药学实践与服务, 2024, 42(10): 433-438, 444. doi: 10.12206/j.issn.2097-2024.202310049
[13]	张林晨, 张小琴, 张俊平. 山楂酸药理作用的研究进展 . 药学实践与服务, 2024, 42(5): 185-189. doi: 10.12206/j.issn.2097-2024.202307052
[14]	刘依秦, 王超群, 邱娇娜. 胆宁片预处理在糖尿病患者结肠镜检查前的应用效果分析 . 药学实践与服务, 2024, 42(9): 407-410. doi: 10.12206/j.issn.2097-2024.202407037
[15]	丁千雪, 尚圣兰, 余梦辰, 余爱荣. 机器学习在肾病综合征患者他克莫司个体化用药中的应用 . 药学实践与服务, 2024, 42(6): 227-230, 243. doi: 10.12206/j.issn.2097-2024.202310007
[16]	宋泽成, 陈林林, 鲁仁义, 刘梦肖, 王彦. 脓毒症治疗的研究进展 . 药学实践与服务, 2024, 42(11): 1-5. doi: 10.12206/j.issn.2097-2024.202405059
[17]	王晓飞, 张颖, 顾佳钰, 胡馨儿, 张海, 曹岩. 表面等离子共振传感器的识别元件在医药领域中的研究应用进展 . 药学实践与服务, 2024, 42(): 1-9. doi: 10.12206/j.issn.2097-2024.202309014
[18]	杨凤艳, 张月, 陈恩贤, 缪雪蓉, 魏凯. 瑞马唑仑临床应用研究进展 . 药学实践与服务, 2024, 42(9): 365-374. doi: 10.12206/j.issn.2097-2024.202405026
[19]	景凯, 杨慈荣, 张圳, 臧艺蓓, 刘霞. 黄芪甲苷衍生物治疗慢性心力衰竭小鼠的药效评价及作用机制研究 . 药学实践与服务, 2024, 42(5): 190-197. doi: 10.12206/j.issn.2097-2024.202310004
[20]	迟文雅, 袁艳, 李伟林, 吴茼妤, 俞媛. 负载骨髓间充质干细胞/白藜芦醇脂质体的水凝胶支架用于创伤性脑损伤治疗 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202406034

点击查看大图

计量

文章访问数: 3009
HTML全文浏览量: 301
PDF下载量: 143
被引次数: 0

姓名
邮箱
手机号码
标题
留言内容
验证码

留言板

聚乙烯醇衍生物作为水凝胶材料的应用研究进展

doi: 10.3969/j.issn.1006-0111.2013.03.002

Applied research of polyvinyl alcohol derivatives as hydrogel materials

计量

聚乙烯醇衍生物作为水凝胶材料的应用研究进展

doi: 10.3969/j.issn.1006-0111.2013.03.002

安徽中医学院, 安徽合肥 230031

English Abstract

Applied research of polyvinyl alcohol derivatives as hydrogel materials

Anhui University of Traditional Chinese Medicine, Hefei 230031, China

全文HTML

目录

留言板

聚乙烯醇衍生物作为水凝胶材料的应用研究进展

doi: 10.3969/j.issn.1006-0111.2013.03.002

Applied research of polyvinyl alcohol derivatives as hydrogel materials

计量

出版历程

聚乙烯醇衍生物作为水凝胶材料的应用研究进展

doi: 10.3969/j.issn.1006-0111.2013.03.002

安徽中医学院, 安徽 合肥 230031

English Abstract

Applied research of polyvinyl alcohol derivatives as hydrogel materials

Anhui University of Traditional Chinese Medicine, Hefei 230031, China

全文HTML

目录

安徽中医学院, 安徽合肥 230031