辐射致组织损伤凋亡机制的研究概况

杨宏; 倪敏; 赵心彬; 陶霞

doi:10.3969/j.issn.1006-0111.2014.02.005

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

辐射致组织损伤凋亡机制的研究概况

杨宏, 倪敏, 赵心彬, 陶霞

文章导航 > 药学实践与服务 > 2014 > 32(2): 96-97,149

杨宏, 倪敏, 赵心彬, 陶霞. 辐射致组织损伤凋亡机制的研究概况[J]. 药学实践与服务, 2014, 32(2): 96-97,149. doi: 10.3969/j.issn.1006-0111.2014.02.005

引用本文:

杨宏, 倪敏, 赵心彬, 陶霞. 辐射致组织损伤凋亡机制的研究概况[J]. 药学实践与服务, 2014, 32(2): 96-97,149. doi: 10.3969/j.issn.1006-0111.2014.02.005

YANG Hong, NI Min, ZHAO Xinbin, TAO Xia. Role of apoptosis in radiation-induced tissue damage[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 96-97,149. doi: 10.3969/j.issn.1006-0111.2014.02.005

Citation:

YANG Hong, NI Min, ZHAO Xinbin, TAO Xia. Role of apoptosis in radiation-induced tissue damage[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 96-97,149. doi: 10.3969/j.issn.1006-0111.2014.02.005

辐射致组织损伤凋亡机制的研究概况

doi: 10.3969/j.issn.1006-0111.2014.02.005

第二军医大学附属长征医院药学部, 上海 200003

Role of apoptosis in radiation-induced tissue damage

Department of Pharmacy, Changzheng Hospital Affiliated to Second Military Medical University, Shanghai 200003, China

摘要: 辐射能够导致组织损伤,其机制通常与细胞凋亡、坏死、炎症等相关。其中细胞凋亡是辐射损伤的主要特征之一,但是凋亡发生的具体机制仍不清楚。研究表明,有多条通路涉及其中,代表性的通路有:聚ADP核糖聚合酶(PARP)、p53、自由基、神经酰胺、p38通路等。本文围绕上述蛋白质分子,综述了凋亡途径在辐射致组织损伤的作用。
- 电离辐射 /
- 损伤机制 /
- 细胞凋亡 /
- 脱氧核糖核酸损伤 /
- 神经酰胺
Abstract: Ionizing radiation is able to induce tissue damage, which is related to cell apoptosis, necrosis and inflammation, etc. The signaling pathway underlying radiation-induced apoptosis remains unclear. However, it's well-accepted that several targets were activated in this process, such as poly (ADP-ribose) polymerase, p53, p38, ceramide, free radicals, etc. Based on these targets, the role of apoptosis in radiation-induced tissue damage was elaborated in this review briefly.
- ionizing radiation /
- damage mechanism /
- cell apoptosis /
- DNA damage /
- ceramide

[1]	周平坤,霍艳英,吴德昌. 辐射致癌效应与机制[J].辐射防护通讯,2007,27(1):7.
[2]	童新,孙志贤. 辐射所致程序性细胞死亡的机制[J].国外医学·分子生物学分册,1995,l7(3):131.
[3]	Tomita M. Involvement of DNA-PK and ATM in radiation-and heat-induced DNA damage recognition and apoptotic cell death[J].J Radiat Res, 2010,51:493.
[4]	Slade D, Radman M. Oxidative stress resistance in Deinococcus radiodurans[J].Microbiol Mol Biol Rev,2011,75(1):133.
[5]	Nguyen TD, Maquart FX, Monboisse JC. Ionizing radiations and collagen metabolism:from oxygen free radicals to radio-induced late fibrosis[J].Radiat Phys Chem,2005, 72:381.
[6]	Orlowski R Z, Baldwin AS. NF-kappaB as a therapeutic target in cancer[J].Trends Mol Med,2002:385.
[7]	Reuter S, Gupta SC, Chaturvedi MM. Oxidative stress, inflammation, and cancer:how are they linked[J].Free Radical Biol Med, 2010, 49:1603.
[8]	Moeller BJ, Cao YT, Li CY. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors:role of reoxygenation, free radicals, and stress granules[J].Cancer Cell, 2004, 5:429.
[9]	Mueller S, Bhargava S, Molinaro AM. Poly (ADP-Ribose) polymerase inhibitor MK-4827 together with radiation as a novel therapy for metastatic neuroblastoma[J].Anticancer Res, 2013, 33(3):755.
[10]	Liu XS. PARP inhibition as a prototype for synthetic lethal screens[J].Mol Biol, 2013, 986:123..
[11]	Shunkwiler L, Ferris G, Kunos C. Inhibition of poly(ADP-Ribose) polymerase enhances radiochemosensitivity in cancers proficient in DNA double-strand break repair[J].Int J Mol Sci, 2013, 14(2):3773.
[12]	Lowe SW. Renewing the debate over the p53 apoptotic response[J].Nature,1993:352.
[13]	Han JQ, Xu XJ, Qin HZ. The molecular mechanism and potential role of heat shock-induced P53 protein accumulation[J].Mol Cellul Biochem, 2013, 3:1.
[14]	Burger H, Nooter K, Boersma AW. Expression of p53, p21/waf/cip, bcl-2, bax, bcl-x, and bak in radiation-induced apoptosis in testicular germ cell tumor lines[J].Int J Radiat Oncol,1998, 41(2):415.
[15]	Wakatsuki M, Ohno T, Iwakawa M. P73 protein expression correlates with radiation-induced apoptosis in the lack of p53 response to radiation therapy for cervical cancer[J].Int J Radiat Oncol,2008, 70(4):1189.
[16]	Deng XZ, Yin XL, Allan R. Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans[J].Science,2008, 322(5898):110.
[17]	Adriana HF, Chu CK, Ehleiter D. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis[J].J Exp Med,1994, 180:525.
[18]	Rotolo J, Stancevic B, Zhang JJ, Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice[J].J Clin Invest,2012, Brief report:1.
[19]	Kolesnick R, Fuks Z. Radiation and ceramide-induced apoptosis[J].Oncogene,2003, 22:5897.
[20]	Niaudet C, Bonnaud S, Gouard S. Radiation induces p38-mediated endothelial cell death through ceramide generation and menbrane remodeling[J].Radioprotection, 2008, 43:140.
[21]	Chakravarti A, Noll E, Black PM. The anti-epidermal growth factor receptor monoclonal antibody, c225, enhances radiation-induced apoptosis in primary glioma cell lines through mediation of MAPK/JNK/p38 signaling pathways[J].Int J Radiat Oncol,2001, 51(3):102.
[22]	Blirando K, Hneino M, Martelly I. Mast cells and ionizing radiation induce a synergistic expression of inflammatory genes in endothelial cells by a mechanism involving p38α MAP kinase and (p65) NF-κB activation[J].Radiat Res,2012, 178(6):556.

[1]	陈静, 何瑞华, 翁月, 徐熠, 刘静, 黄瑾. 基于网络药理学和分子对接技术探究定清片活性成分治疗白血病的作用机制 . 药学实践与服务, 2024, 42(11): 1-8. doi: 10.12206/j.issn.2097-2024.202401073
[2]	张广雨, 杜晶, 刘梦珍, 朱丹妮, 闫慧, 刘冲. 新斯的明与山莨菪碱联合应用对肺型氧中毒的保护作用及其机制的研究 . 药学实践与服务, 2024, 42(10): 433-438, 444. doi: 10.12206/j.issn.2097-2024.202310049
[3]	岳春华, 贲永光, 王海桥. 基于NLRP1炎症小体探讨百合知母汤抗抑郁的作用机制 . 药学实践与服务, 2024, 42(8): 325-333. doi: 10.12206/j.issn.2097-2024.202401033
[4]	景凯, 杨慈荣, 张圳, 臧艺蓓, 刘霞. 黄芪甲苷衍生物治疗慢性心力衰竭小鼠的药效评价及作用机制研究 . 药学实践与服务, 2024, 42(5): 190-197. doi: 10.12206/j.issn.2097-2024.202310004
[5]	钱淑雨, 李铁军. 耐碳青霉烯类肠杆菌耐药机制的研究进展 . 药学实践与服务, 2024, 42(10): 419-425. doi: 10.12206/j.issn.2097-2024.202405005
[6]	杨彬, 王作君, 陈菡, 张敬一. 基于DRGs的医院合理用药管理机制探索实践 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404030
[7]	李清, 郭宜银, 陈颖, 瞿发林, 董文燊, 戈煜. 夜宁胶囊对小鼠镇静催眠作用及其机制的研究 . 药学实践与服务, 2024, 42(8): 346-349. doi: 10.12206/j.issn.2097-2024.202211047
[8]	徐飞, 陈瑾, 鲁育含, 李志勇. 肠道菌群参与糖尿病肾病的机制研究进展 . 药学实践与服务, 2024, 42(5): 181-184, 197. doi: 10.12206/j.issn.2097-2024.202312023
[9]	刘丽艳, 余小翠, 孙传铎. 纳武利尤单抗治疗非小细胞肺癌有效性及安全性的Meta分析 . 药学实践与服务, 2024, 42(10): 451-456. doi: 10.12206/j.issn.2097-2024.202310044
[10]	宋雨桐, 夏德润, 顾珩, 唐少文, 易洪刚, 沃红梅. 帕博利珠单抗与铂类化疗方案在晚期非小细胞肺癌一线治疗中的药物经济学评价 . 药学实践与服务, 2024, 42(8): 334-340. doi: 10.12206/j.issn.2097-2024.202303023
[11]	杨媛媛, 安晓强, 许佳捷, 江键, 梁媛媛. 正极性驻极体联合5-氟尿嘧啶对瘢痕成纤维细胞生长抑制的协同作用 . 药学实践与服务, 2024, 42(6): 244-247. doi: 10.12206/j.issn.2097-2024.202310027
[12]	陈莹, 许子华, 胡北, 崔亚玲, 高欢, 吴琼. 通便灵胶囊治疗便秘的药效与机制研究 . 药学实践与服务, 2024, 42(): 1-7. doi: 10.12206/j.issn.2097-2024.202404008
[13]	李想, 陆鸿远, 张明玉, 高欢, 姚东, 许子华. 米格列醇激活UCP1介导棕色脂肪对冷暴露小鼠损伤的研究 . 药学实践与服务, 2024, 42(): 1-6. doi: 10.12206/j.issn.2097-2024.202404005
[14]	修建平, 杨朝爱, 刘禧澳, 潘乾禹, 韦广旭, 王卫星. 全反式维甲酸对肝星状细胞活化及氧化应激的作用和机制探索 . 药学实践与服务, 2024, 42(7): 291-296. doi: 10.12206/j.issn.2097-2024.202312054
[15]	张岩, 李炎君, 刘家荟, 邓娇, 原苑, 张敬一. 药物性肝损伤不良反应分析 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404034
[16]	冯志惠, 邓仪卿, 叶冰, 安培, 张宏, 张海军. 雀梅藤石油醚提取物诱导三阴性乳腺癌细胞凋亡的实验研究 . 药学实践与服务, 2024, 42(6): 253-259. doi: 10.12206/j.issn.2097-2024.202311055
[17]	迟文雅, 袁艳, 李伟林, 吴茼妤, 俞媛. 负载骨髓间充质干细胞/白藜芦醇脂质体的水凝胶支架用于创伤性脑损伤治疗 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202406034
[18]	姜涛, 徐卫凡, 蒋益萍, 夏天爽, 辛海量. 巴戟天丸组方对Aβ损伤成骨细胞的作用及基于网络药理学的机制研究 . 药学实践与服务, 2024, 42(7): 285-290, 296. doi: 10.12206/j.issn.2097-2024.202305011

点击查看大图

计量

文章访问数: 3145
HTML全文浏览量: 428
PDF下载量: 91
被引次数: 0

辐射致组织损伤凋亡机制的研究概况

doi: 10.3969/j.issn.1006-0111.2014.02.005

第二军医大学附属长征医院药学部, 上海 200003

收稿日期: 2013-03-11
修回日期: 2013-06-14

关键词:

摘要: 辐射能够导致组织损伤,其机制通常与细胞凋亡、坏死、炎症等相关。其中细胞凋亡是辐射损伤的主要特征之一,但是凋亡发生的具体机制仍不清楚。研究表明,有多条通路涉及其中,代表性的通路有:聚ADP核糖聚合酶(PARP)、p53、自由基、神经酰胺、p38通路等。本文围绕上述蛋白质分子,综述了凋亡途径在辐射致组织损伤的作用。