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2023 Vol. 41, No. 1

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Research progress of immunotherapies on correction of immunoparalysis in sepsis
XING Xinhao, CHEN Linlin, LING Zhongyi, WANG Yan
2023, 41(1): 1-7, 35. doi: 10.12206/j.issn.2097-2024.202203113
Abstract(6289) HTML (4088) PDF (1384KB)(49)
Abstract:
Immunoparalysis is the main cause of death in patients with intermediate and terminal sepsis. The correction of immunoparalysis is an important direction of sepsis treatment. In the pathological process of sepsis, a variety of factors contribute to the imbalanced secretion of cytokines, weakened function of antigen-presenting cells, apoptosis and depletion of lymphocytes, and ultimately lead to immunoparalysis, secondary infection, and even patient deaths. Cytokines such as GM-CSF, IFN-γ, IL-7, and IL-15, immune checkpoint-related therapies such as PD-1/PD-L1 antibodies, CTLA-4 antibodies, TIM-3 antibodies, and LAG-3 antibodies, and immunoreactive substances such as thymosin α1 and immunoglobulin might be beneficial to correct the immune paralysis of patients. the progress of immunotherapy to correct immune paralysis in sepsis were reviewed in this article.
Research overview of anti-osteoporosis effects of traditional animal medicines
ZHANG Jingwen, XIA Tianshuang, JIANG Yiping, XIN Hailiang
2023, 41(1): 8-13. doi: 10.12206/j.issn.2097-2024.202101032
Abstract(5130) HTML (3144) PDF (986KB)(34)
Abstract:
Osteoporosis is a systemic bone metabolism disease characterized by low bone mass, bone microstructure destruction, increased bone fragility, and easy fracture, which is more common in the elderly. Animal medicine, as an important part of natural medicines, has the characteristics of wide resources, complex chemical components, and broad pharmacological effects. It has been extensively used in the field of anti-osteoporosis. This article summarizes the pharmacological effects and applications of several major animal medicines for osteoporosis, and discusses the existing problems, aiming to provide a reference for the development of animal drugs against osteoporosis.
Application progress of ROS-responsive liposomes in anti-tumor research
GAO Xiqing, LU Guangzhao, LU Ying, ZOU Hao
2023, 41(1): 14-17. doi: 10.12206/j.issn.2097-2024.202105086
Abstract(6356) HTML (2344) PDF (880KB)(108)
Abstract:
Reactive oxygen species(ROS) responsive liposomes are prepared based on the high level of ROS expression in the tumor microenvironment, enabling precise drug delivery to the tumor site. With the addition of photosensitizer, the controllability of drugs in liposomes can be further enhanced.
Design, synthesis and degradation activity of BRD4-targeting ATTECs
ZHOU Luozhu, SHENG Chunquan
2023, 41(1): 18-25. doi: 10.12206/j.issn.2097-2024.202206050
Abstract(2957) HTML (1175) PDF (1461KB)(30)
Abstract:
  Objective   To design and synthesize autophagic degraders targeting BRD4 based on autophagosome tethering compound (ATTEC) strategy and test their BRD4 degradation activity.   Methods   BRD4-targeting ATTECs were constructed by conjugating ispinesib that used as a LC3 ligand and JQ1 through a variety of alkane linkers. The final compounds were confirmed by 1H NMR, 13C NMR and ESI-MS, and their degradation activity in different cell lines were tested by Western Blot.   Results   Five BRD4-ATTEC molecules were successfully synthesized for the first time. Compound 4 showed moderate BRD4 degradation activity in different cell lines.   Conclusion   The novel BRD4 autophagic degraders were discovered, which expanded the applicability of targeted autophagic degradation via ATTEC.
Preparation and anti-Vibrio vulnificus hemolysin A of macrophage membrane hybrid liposome
DAI Yu, GUO Lingyi, WANG Hongbo, BIAN Kangqing, YU Yuan
2023, 41(1): 26-30, 55. doi: 10.12206/j.issn.2097-2024.202207001
Abstract(3636) HTML (1350) PDF (3163KB)(26)
Abstract:
  Objective  To prepare a biomimetic nano carrier macrophage membrane hybrid liposome by heterozygous macrophage membrane and liposome, which could be used for the clearance and toxicity inhibition of Vibrio vulnificus hemolysin A (VvhA).   Methods  Macrophage membrane was extracted and hybridized with liposome by thin-film evaporation combined extrusion method. The hybridized liposome of macrophage membrane was constructed and characterized. The in vitro detoxification ability of the hybridized vector was evaluated by hemolysis test and cytotoxicity test. The detoxification ability of the vector was evaluated by mouse skin infection model.   Results  Anti toxoid studies in vivo and in vitro showed that the anti-hemolysis rate of macrophage membrane heterozygous liposomes in vitro reached 97.03%, which could effectively inhibit the skin ulceration in subcutaneous infected mice and make the survival rate of abdominal infected mice reach 80%.   Conclusion  The constructed macrophage membrane hybrid liposome had high detoxification ability, which could provide a potential solution and research basis for the prevention and treatment of Vibrio vulnificus infection.
Analysis of medication rules of TCM for perimenopausal syndrome based on literature mining
GAO Min, YANG Yingbo, LIN Li, YING Lingxuan, SUN Lianna, XIAO Wei
2023, 41(1): 31-35. doi: 10.12206/j.issn.2097-2024.202203034
Abstract(3660) HTML (1599) PDF (1112KB)(10)
Abstract:
  Objective  To investigate the rules of Traditional Chinese Medicine in the treatment of perimenopausal syndrome (PMS) and provide a theoretical basis for the clinical treatment of PMS.   Methods  The literature related to PMS were collected from China Knowledge Network (CNKI), Wanfang database and Weipu database in the past 20 years, the herbal compound prescriptions for the treatment of PMS were screened and a relevant database were established and analyzed by SPSS.   Results   The relevant literatures contains 184 Chinese medicine prescriptions/proprietary Chinese medicines, 122 flavors of traditional Chinese medicines, and the drug categories were mainly tonic drugs, antipyretic drugs, astringent drugs, and tranquilizers. The core single-flavor Chinese medicines were Baishao(Radix Paeoniae Alba), Shudihuang(Rehmannia glutinosa ), Danggui(Radix Angelicae Sinensis), Fuling (Indian Buead). The property and flavor covered sweet, bitter, cold, etc.; and the channel tropism belonged to the liver, kidneys, heart, lungs, spleen and meridians. The cluster analysis of high-frequency Traditional Chinese Medicine obtained two main combinations.   Conclusion   TCM treatment of PMS focused on replenishing qi, soothing the liver, nourishing the kidneys, nourishing blood and calming the heart, and then according to clinical compatibility with drugs such as soothing the nerves, clearing heat and removing dampness; most of its clinical treatment were Xiaoyaosan, Liuwei Dihuang pills, and Zhibo Rehmanniae decoction and other prescriptions which were added and subtracted.
Dissolution behavior of aripiprazole tablets based on near infrared spectroscopy
WANG Weiqing, YANG Wen, LU Feng
2023, 41(1): 36-39, 62. doi: 10.12206/j.issn.2097-2024.202108066
Abstract(2460) HTML (938) PDF (1392KB)(29)
Abstract:
  Objective  To establish a near infrared (NIR) quantitative model for the dissolution behavior of aripiprazole tablets.   Methods  The NIR spectra of aripiprazole tablets were collected and the dissolution tests were performed to determine the dissolution of each tablet at 3, 6, 9, 12, 15 and 30 min. The near infrared spectra regions of 4 000.00-4 396.90, 5 326.43-12 000.00 cm−1 were pretreated by Savitzky-Golay smoothing filter, and the dissolution behavior model was established by partial least squares method.   Results  The root mean square error of calibration (RMSEC) and the root mean square error of prediction (RMSEP) at different time points were analyzed. RMSEP was lower than 8%. The calibration correlation coefficient (RC) and the prediction correlation coefficient (RP) at different time points were above 0.95 (except for the point of 6 min). There was a good correlation between the NIR spectrum and the dissolution at each time point.   Conclusion  NIR spectroscopy could predict the dissolution behavior of aripiprazole tablets, which lays a foundation for online quality monitoring of tablets by NIR spectroscopy.
Therapeutic effects of estrogen-intervened EPCs transplantation on diabetic ischemic stroke rats
DONG Yafen, WANG Jian, CHEN Ye, LI Shushu, LIU Helong, QIU Yan
2023, 41(1): 40-44, 49. doi: 10.12206/j.issn.2097-2024.202111111
Abstract(4570) HTML (1668) PDF (2282KB)(8)
Abstract:
  Objective   To explore the therapeutic effects of estrogen-intervened endothelial progenitor cells( EPCs) transplantation on diabetic ischemic stroke rats.   Methods  PKH26-labeled diabetic EPCs and estrogen-intervened diabetic EPCs were injected into rats via the tail vein 24 h after cerebral ischemia. Cerebral ischemic volume, behavioral changes, ischemic site vascularization and homing of EPCs were measured 3 d after EPCs injection.   Results  Compared with diabetic ischemic rats, estrogen-intervened EPCs transplantation had reduced infarct volumes, improved behavioral scores and ischemic site revascularization and promoted homing of EPCs to sites of injury(P<0.05).   Conclusion  Estrogen-intervened EPCs transplantation had a better therapeutic effect on diabetic ischemic stroke by promoting EPCs homing to injury site and EPCs-medicated neovascularization .
Studies on orally disintegrating tablet of diphenhydramine hydrochloride and caffeine
FAN Li, ZENG Yuan, XIE Xiangyang, LIU Hui, XIONG Jing, ZHANG Ying, YUAN Yuan
2023, 41(1): 45-49. doi: 10.12206/j.issn.2097-2024.202108090
Abstract(3714) HTML (1488) PDF (959KB)(27)
Abstract:
  Objective  To optimize the formulation and preparation of diphenhydramine hydrochloride and caffeine orally disintegrating tablet.   Methods   Melt granulation technology of steric acid and API was used to mask the unpleasant tasting of diphenhydramine hydrochloride. The tablets were prepared by direct pressing the dry powder with CCMC-Na as disintegrating agent. The formulation was optimized by orthogonal experiments to achieve the shortest disintegration time and the best taste correction.   Results   The optimized formula of orally disintegrating tablet was as follows: diphenhydramine hydrochloride 25 mg, caffeine 60 mg, stearic acid 25 mg, aspatan 40 mg, blueberry essence 7 mg, mannitol 45 mg, MCC 210 mg, CCMC-NA 25 mg, SDS 8 mg and magnesium stearate 5 mg.  Conclusion  This preparation method for orally disintegrating tablet of diphenhydramine hydrochloride and caffeine is practical and easy for quality control.
Evaluation on genotoxicities of raceanisodamine hydrochloride injection
TIAN Yijun, SHI Wenjing, DONG Yachun, ZHANG Tianbao, ZHU Yuping
2023, 41(1): 50-55. doi: 10.12206/j.issn.2097-2024.202206035
Abstract(3557) HTML (1276) PDF (1149KB)(7)
Abstract:
  Objective  To study the genotoxicities of raceanisodamine hydrochloride injection.   Methods  Bacterial reverse mutation test, in vitro Chromosomal aberration test and in vivo Micronucleus test were performed to investigate the genotoxicities of raceanisodamine hydrochloride injection.   Results  The Ames test showed that raceanisodamine hydrochloride injection did not increase mutagenicity for TA1535, TA102, TA100, TA98 and TA97 strains at the dosage of 0.5, 5, 50, 500, 5000 μg per plate under two parallel system conditions (±S9). Results of CA test indicated that there was no statistical difference between raceanisodamine hydrochloride injection groups (doses of 58.75,117.5 and 235.0 μg/ml) and the solvent control group under two parallel system conditions (±S9). In MNT test, with doses of 7.5, 15.0 and 30.0 mg/kg respectively, the micronucleus induction rate of bone marrow of ICR mice was not statistically significant (P>0.05) when compared with that of vehicle control group in all dose groups.   Conclusion  Under the conditions of these study, the results indicated that raceanisodamine hydrochloride injection had no mutagenicity to Salmonella typhimurium, had no aberration effect on the chromosome of mammalian cultured cells, and had no effect on inducing micronucleus of bone marrow polychromatic erythrocytes in ICR mouse. All test results showed that raceanisodamine hydrochloride injection had no potential carcinogenicities and genetic toxicities under the test conditions.
Clinical effect of compound phellodendron gargle with total glucosides of paeony capsule in the treatment of erosive oral lichen planus
WU Ruihan, MA Yanhong
2023, 41(1): 56-58. doi: 10.12206/j.issn.2097-2024.202208052
Abstract(3171) HTML (1209) PDF (881KB)(4)
Abstract:
  Objective  To observe the short-term clinical effect of compound phellodendron gargle combined with the total glucosides of paeony (TGP) in the treatment of erosive oral lichen planus (OLP).   Methods  62 patients were divided into observation group and control group through a designed parallel randomized controlled study. All the patients used the total glucosides of paeony capsule , the patients in the observation group also used the compound phellodendron gargle. The pain condition, the healing condition of face, and the treatment effective in both group were evaluated through physical signs and VAS scores evaluations by SPSS 22.0, which could further evaluate the short-term clinical efficacy of compound phellodendron.   Results  After 30 days, the scores of VAS and physical signs of each group are much better than before. And the scores of VAS and treatment effective of observation group were significantly better than those of the other control groups (P<0.05).   Conclusion  The application of phellodendron gargle with total glucosides of paeony capsule could improve the treatment effect of OLP patients and reduce the oral pain , which could be used widely in clinical practice.
Pharmaceutical care for a Crohn's disease patient with hypoalbuminemia and non-response to infliximab
LIN Tingting, ZENG Tingting, TIAN Jing
2023, 41(1): 59-62. doi: 10.12206/j.issn.2097-2024.202102009
Abstract(2202) HTML (1277) PDF (911KB)(22)
Abstract:
  Objective  To investigate the role of clinical pharmacists in individualized treatment and pharmaceutical care for a Crohn’s disease patient with non-response to infliximab.   Methods  The clinical pharmacist participated in the pharmaceutical care for a Crohn’s disease patient with hypoalbuminemia. Clinical pharmacists interpreted the blood concentration results of infliximab based on literature review, analyzed the pharmacokinetic process of drugs, and suggested that low serum albumin levels may cause the accelerated drug elimination and resulted in reduced drug concentration and secondary non-response.   Results  Clinical pharmacists assisted clinician adjusting the medication regimen and the patient recovered well after the new treatment plan.   Conclusion  With good understanding in medication pharmacokinetics and the blood test results, clinical pharmacists can help to solve the drug therapy related problems and establish an individual treatment plan to improve the safety and effectiveness of the biological medications.