黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

李小宁; 卫新国; 尚云; 卫洪昌; 朱晓梅; 孙平龙; 严世芸

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黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸

文章导航 > 药学实践与服务 > 2001 > (5): 270-272

李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸. 黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响[J]. 药学实践与服务, 2001, (5): 270-272.

引用本文:

李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸. 黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响[J]. 药学实践与服务, 2001, (5): 270-272.

LI Xiao-ning, WEI Xin-guo, SHANG Yun, WEI Hong-chang, ZHU Xiao-mei, SUN Ping-long, YAN Shi-yun. Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 270-272.

Citation:

LI Xiao-ning, WEI Xin-guo, SHANG Yun, WEI Hong-chang, ZHU Xiao-mei, SUN Ping-long, YAN Shi-yun. Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 270-272.

黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

1.
上海市南汇县光明中医医院, 上海201300
2.
上海中医药大学, 上海200032

Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction

1.
Guangming Hospital of TCM, Nanhui, Shanghai 201300, China
2.
Shanghai University of Traditional Chinese Medicine and Pharmacy, Shanghai 200032, China

摘要: 目的探讨黄芪保心汤地实验性急性心肌缺血大鼠血浆内皮素(ET)、降钙素基因相关肽(CGRP)水平的影响。方法 44只大白鼠随机分为4组:假手术组,模型对照组,黄芪保心汤组,复方丹参滴丸组。结扎左冠状动脉前降支造成急性心肌缺血模型,观察3h后,从腹主动脉取血检测血浆ET、CGRP水平。结果黄芪保心汤组,能显着降低血浆ET含量(P<0.001),升高血浆GGRP水平(P<0.01)。结论以益气活血祛痰化浊为主的黄芪保心汤有调节急性心肌缺血时血浆ET、CGRP水平失衡的作用,改善心肌缺血、缺氧状态,减少心肌缺血损伤,且作用优于复方丹参滴丸。
- 急性实验性心肌缺血 /
- 内皮素 /
- 降钙素基因相关肽 /
- 黄芪保心汤
Abstract: OBJECTIVE To investigate the influence of Astragalus heart keeping decoction on the level of plasma endothelin(El') and calcitonin gene related peptide (CGRP) in rats during the coronary artery occlusion in vivo. METHODS 44 rats were devided randomly into the sham ligation group, the control group, the Astragalus heart -keeping decoction (AHKD) group, the Composite Danshen Droplet Pills (CDDP) group. Various groups of the rats were fed with water, AHKD, CDDP for four weeks, respectively. And then rats were subjected to left anterior descending artery occlusion for 3 hour. for the determination of plasma El' and CGRP. RESULTS the level of plasma ET was lower on average in the group of AHKD than in the control group(P<0.01),and in comparison with the control group there was no significant difference in plasma ET in the group of CDDP (P<0.05). The level of plasma CGRP in the AHKD and CDDP groups was higher than that of plasma CGRP in the control group (P<0.01). CONCLUSION AHKD and CDDP have the function to regulate the level of plasma ET and CGRP in rats during the coronary artery occlusion, to improve myocardial ischemia,and that the efficacy of AHKD is superior to that of CDDP.
- astragalus heart-keeping decoction /
- acute myocardial infarction /
- experimental study /
- ET

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黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

1. 上海市南汇县光明中医医院, 上海201300

2. 上海中医药大学, 上海200032

收稿日期: 2001-04-24

关键词:

急性实验性心肌缺血 /

内皮素 /

降钙素基因相关肽 /

黄芪保心汤

摘要: 目的探讨黄芪保心汤地实验性急性心肌缺血大鼠血浆内皮素(ET)、降钙素基因相关肽(CGRP)水平的影响。方法 44只大白鼠随机分为4组:假手术组,模型对照组,黄芪保心汤组,复方丹参滴丸组。结扎左冠状动脉前降支造成急性心肌缺血模型,观察3h后,从腹主动脉取血检测血浆ET、CGRP水平。结果黄芪保心汤组,能显着降低血浆ET含量(P<0.001),升高血浆GGRP水平(P<0.01)。结论以益气活血祛痰化浊为主的黄芪保心汤有调节急性心肌缺血时血浆ET、CGRP水平失衡的作用,改善心肌缺血、缺氧状态,减少心肌缺血损伤,且作用优于复方丹参滴丸。

English Abstract

Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction

1. Guangming Hospital of TCM, Nanhui, Shanghai 201300, China

2. Shanghai University of Traditional Chinese Medicine and Pharmacy, Shanghai 200032, China

Received Date: 2001-04-24

Keywords:

Abstract: OBJECTIVE To investigate the influence of Astragalus heart keeping decoction on the level of plasma endothelin(El') and calcitonin gene related peptide (CGRP) in rats during the coronary artery occlusion in vivo. METHODS 44 rats were devided randomly into the sham ligation group, the control group, the Astragalus heart -keeping decoction (AHKD) group, the Composite Danshen Droplet Pills (CDDP) group. Various groups of the rats were fed with water, AHKD, CDDP for four weeks, respectively. And then rats were subjected to left anterior descending artery occlusion for 3 hour. for the determination of plasma El' and CGRP. RESULTS the level of plasma ET was lower on average in the group of AHKD than in the control group(P<0.01),and in comparison with the control group there was no significant difference in plasma ET in the group of CDDP (P<0.05). The level of plasma CGRP in the AHKD and CDDP groups was higher than that of plasma CGRP in the control group (P<0.01). CONCLUSION AHKD and CDDP have the function to regulate the level of plasma ET and CGRP in rats during the coronary artery occlusion, to improve myocardial ischemia,and that the efficacy of AHKD is superior to that of CDDP.

李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸. 黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响[J]. 药学实践与服务, 2001, (5): 270-272.

引用本文:

李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸. 黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响[J]. 药学实践与服务, 2001, (5): 270-272.

Citation:

LI Xiao-ning, WEI Xin-guo, SHANG Yun, WEI Hong-chang, ZHU Xiao-mei, SUN Ping-long, YAN Shi-yun. Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 270-272.

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黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction

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黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

1. 上海市南汇县光明中医医院, 上海201300 2. 上海中医药大学, 上海200032

English Abstract

Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction

1. Guangming Hospital of TCM, Nanhui, Shanghai 201300, China 2. Shanghai University of Traditional Chinese Medicine and Pharmacy, Shanghai 200032, China

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目录

1. 上海市南汇县光明中医医院, 上海201300

2. 上海中医药大学, 上海200032

1. Guangming Hospital of TCM, Nanhui, Shanghai 201300, China

2. Shanghai University of Traditional Chinese Medicine and Pharmacy, Shanghai 200032, China