留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

知母皂苷及其苷元的药理作用研究进展

蔡飞 王维泓 高守红 陈万生

蔡飞, 王维泓, 高守红, 陈万生. 知母皂苷及其苷元的药理作用研究进展[J]. 药学实践与服务, 2011, 29(5): 331-335.
引用本文: 蔡飞, 王维泓, 高守红, 陈万生. 知母皂苷及其苷元的药理作用研究进展[J]. 药学实践与服务, 2011, 29(5): 331-335.
CAI Fei, WANG Wei-hong, GAO Shou-hong, CHEN Wan-sheng. Advances in the pharmacological studies on timosaponins and their sapogenins[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 331-335.
Citation: CAI Fei, WANG Wei-hong, GAO Shou-hong, CHEN Wan-sheng. Advances in the pharmacological studies on timosaponins and their sapogenins[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 331-335.

知母皂苷及其苷元的药理作用研究进展

Advances in the pharmacological studies on timosaponins and their sapogenins

  • 摘要: 知母皂苷及其苷元是临床常用中药材知母的最主要活性成分,具有广泛的生物活性和药理作用。研究表明,知母皂苷及其苷元具有防治老年痴呆症、保护脑缺血损伤、抗凝血、抗氧化、抗肿瘤、抗骨质疏松、抗炎、降血压、降血糖及降血脂等药理活性。本文对知母皂苷及其苷元的上述药理作用研究进展进行综述,为进一步开发利用提供参考。
  • [1] 廖洪利,王伟新,赵福胜,等. 知母化学成分研究进展[J]. 药学实践杂志,2005,23(1):12.
    [2] 夏宗勤,胡雅儿,陈曹林. 知母皂苷元及其异构体对老年大鼠学习记忆和脑内M1受体密度的影响[J]. 中国药理学通报,2004,20(5):561.
    [3] Hu Y,Xia Z,Sun Q,et al. A new approach to the pharmacological regulation of memory: Sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models[J]. Brain Res,2005,1060(1-2):26.
    [4] Hu H,Zhang R,Zhang Y,et al. Role of CREB in the regulatory action of sarsasapogenin on muscarinic M1 receptor density during cell aging[J]. FEBS Lett,2010,584(8):1549.
    [5] 王顺宫,徐江平. 知母皂苷对衰老大鼠脑乙酰胆碱受体的调节作用[J]. 解放军药学学报,2001,17(2):71.
    [6] 欧阳石,孙莉莎,徐江平. 知母总皂苷对大鼠脑皮质乙酰胆碱酯酶的抑制作用[J]. 中国药学杂志,2006,41(19):1472.
    [7] Lee B,Jung K,Kim DH. Timosaponin A-III,a saponin isolated from Anemarrhena asphodeloides,ameliorates learning and memory deficits in mice[J]. Pharmacol Biochem Behav,2009,93(2):121.
    [8] Ouyang S,Sun L,Guo S,et al. Effects of timosaponins on learning and memory abilities of rats with dementia induced by lateral cerebral ventricular injection of amyloid beta-peptide[J]. 第一军医大学学报,2005,25(2):121.
    [9] 钟 雷,谭 洁,欧阳石,等. 知母皂苷B对大鼠海马注射β-AP (25~35)致tau蛋白磷酸化的影响[J]. 南方医科大学学报,2006,26(8):1106.
    [10] Li TJ,Qiu Y,Yang PY,et al. Timosaponin B-II improves memory and learning dysfunction induced by cerebral ischemia in rats[J]. Neurosci Lett,2007,421(2):147.
    [11] Oh JK,Hyun SY,Oh HR,et al. Effects of Anemarrhena asphodeloides on focal ischemic brain injury induced by middle cerebral artery occlusion in rats[J]. Biol Pharm Bull,2007,30(1):38.
    [12] 原 源. 知母防治缺血性脑中风的物质基础及品质评价[D]. 上海:第二军医大学,2005.
    [13] 邓 云,徐秋萍,刘振权,等. 知母皂苷化合物对脑缺血再灌注大鼠的保护作用[J]. 北京中医药大学学报,2005,28(2):33.
    [14] 吴 非,黎红华,陈文军. 脑缺血再灌注损伤后一氧化氮合酶表达变化及知母总皂苷对其影响[J]. 中华神经医学杂志,2006,5(8):757.
    [15] Niwa A,Takeda O,Ishimaru M,et al. Screening test for platelet aggregation inhibitor in natural products. The active principle of Anemarrhenae Rhizoma[J]. Yakugaku Zasshi,1988,108(6):555.
    [16] 李素燕,赵振虎,裴海云,等. 知母皂苷AⅢ抗血栓作用研究[J]. 军事医学科学院院刊,2006,30(004):340.
    [17] Dong JX,Han GY. A new active steroidal saponin from Anemarrhena asphodeloides[J]. Planta Med,1991,57(5):460.
    [18] Zhang J,Meng Z,Zhang M,et al. Effect of six steroidal saponins isolated from Anemarrhenae rhizoma on platelet aggregation and hemolysis in human blood[J]. Clin Chim Acta,1999,289(1-2):79.
    [19] Kaname N,Zhang J,Meng Z,et al. Effect of timosaponin E1 and E2 on superoxide generation induced by various stimuli in human neutrophils and on platelet aggregation in human blood[J]. Clin Chim Acta,2000,295(1-2):129.
    [20] Chen ND,Yue L,Zhang J,et al. One unique steroidal sapogenin obtained through the microbial transformation of ruscogenin by Phytophthora cactorum ATCC 32134 and its potential inhibitory effect on tissue factor (TF) procoagulant activity[J]. Bioorg Med Chem Lett,2010,20(14):4015.
    [21] Meng ZY,Zhang JY,Xu SX,et al. Steroidal Saponins from Anemarrhena asphodeloides and their Effects on Supberoxide Generation[J]. Planta Med,1999,65(7):661.
    [22] 邓 云,马百平,从玉文,等. 知母皂苷BⅡ对Aβ25-35诱导的原代大鼠神经细胞损伤的保护作用[J]. 中国药理学通报,2009,25(2):244.
    [23] Li PM,Zhong JL,Chen RQ,et al. Zhi-mu saponin inhibits [alpha]-fetoprotein gene expression in developing rat liver[J]. Int J Biochem,1989,21(1):15.
    [24] 王丽娟,付 勤. 薯蓣皂苷元体内、外的抗肿瘤作用[J]. 中国中药杂志,2002,27(10):777.
    [25] Trouillas P,Corbiere C,Liagre B,et al. Structure-function relationship for saponin effects on cell cycle arrest and apoptosis in the human 1547 osteosarcoma cells: a molecular modelling approach of natural molecules structurally close to diosgenin[J]. Bioorg Med Chem,2005,13(4):1141.
    [26] Ni Y,Gong X,Lu M,et al. Mitochondrial ROS burst as an early sign in sarsasapogenin-induced apoptosis in HepG2 cells[J]. Cell Biol Int,2008,32(3):337.
    [27] Huang XF,Lin YY,Kong LY. Steroids from the roots of Asparagus officinalis and their cytotoxic activity[J]. J Integr Plant Biol,2008,50(6):717.
    [28] Sy LK,Yan SC,Lok CN,et al. Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells[J]. Cancer Res,2008,68(24):10229.
    [29] King FW,Fong S,Griffin C,et al. Timosaponin A-III is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress[J]. PloS One,2009,4(9):1221.
    [30] Kang YJ,Chung HJ,Nam JW,et al. Cytotoxic and Antineoplastic Activity of Timosaponin A-III for Human Colon Cancer Cells[J]. J Nat Prod,2011,74(4):701.
    [31] 杨 茗,季 晖,张树平,等. 知母皂苷元对成骨细胞活性和破骨细胞分化及功能的影响[J]. 中国药科大学学报,2009,40(6):544.
    [32] Nian H,Qin L,Chen W,et al. Protective effect of steroidal saponins from rhizome of Anemarrhena asphodeloides on ovariectomy-induced bone loss in rats[J]. Acta Pharmacol Sinica,2006,27(6):728.
    [33] Qin L,Han T,Zhang Q,et al. Antiosteoporotic chemical constituents from Er-Xian Decoction,a traditional Chinese herbal formula[J]. J Ethnopharmacol,2008,118(2):271.
    [34] Lu WQ,Qiu Y,Li TJ,et al. Timosaponin B-II inhibits pro-inflammatory cytokine induction by lipopolysaccharide in BV2 cells[J]. Arch Pharm Res,2009,32(9):1301.
    [35] Kim JY,Shin JS,Ryu JH,et al. Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-[kappa] B and p38 pathways[J]. Food Chem Toxicol,2009,47(7):1610.
    [36] 李泽松,李德良,黄 坚,等. 心血管相关基因芯片的制备及其在知母皂苷作用机理研究中的应用[J]. 药学学报,2003,38(7):496.
    [37] 赵树进,韩丽萍. 知母皂苷及其苷元对动物模型β肾上腺素受体的调整作用[J]. 中国医院药学杂志,2000,20(2):70.
    [38] Wang GJ,Lin LC,Chen CF,et al. Effect of timosaponin A-III,from Anemarrhenae asphodeloides Bunge (Liliaceae),on calcium mobilization in vascular endothelial and smooth muscle cells and on vascular tension[J]. Life Sci,2002,71(9):1081.
    [39] Xiao S,Xu M,Ge Y,et al. Inhibitory Effects of Saponins From Anemarrhene asphodeloides Bunge on the Growth of Vascular Smooth Muscle Cells[J]. Biomed Environ Sci,2006,19(3):185.
    [40] Nakashima N,Kimura I,Kimura M,et al. Isolation of pseudoprototimosaponin AIII from rhizomes of Anemarrhena asphodeloides and its hypoglycemic activity in streptozotocin-induced diabetic mice[J]. J Nat Prod,1993,56(3):345.
    [41] 李春梅,高永林,李 敏,等. 知母皂苷对小鼠血糖的影响[J]. 中药药理与临床,2005,21(4):22.
    [42] 韩 兵,李春梅,李 敏,等. 知母皂苷的降脂及抗动脉粥样硬化作用[J]. 上海中医药杂志,2006,40(11):68.
    [43] 付宝才,林 娟,杨林海. 知母总皂苷对高脂血症大鼠肝脏低密度脂蛋白受体活性的影响[J]. 医学综述,2009,15(14):2226.
    [44] Ren LX,Luo YF,Li X,et al. Antidepressant-Like Effects of Sarsasapogenin from Anemarrhena asphodeloides BUNGE (Liliaceae)[J]. Biol Pharm Bull,2006,29(11):2304.
    [45] Takeda O,Tanaka S,Yamasaki K,et al. Screening for molluscicidal activity in crude drugs[J]. Chem Pharm Bull,1989,37(4):1090.
    [46] Lee B,Trinh HT,Jung K,et al. Inhibitory effects of steroidal timosaponins isolated from the rhizomes of Anemarrhena asphodeloides against passive cutaneous anaphylaxis reaction and pruritus[J]. Immunopharmacol Immunotoxicol,2010,32(3):1.
  • [1] 张广雨, 杜晶, 刘梦珍, 朱丹妮, 闫慧, 刘冲.  新斯的明与山莨菪碱联合应用对肺型氧中毒的保护作用及其机制的研究 . 药学实践与服务, 2024, 42(10): 433-438, 444. doi: 10.12206/j.issn.2097-2024.202310049
    [2] 郭灵怡, 刘艳超, 高路, 刘瑞瑶, 吕权真, 俞媛.  醋酸卡泊芬净单硬脂酸甘油酯纳米粒抗白色念珠菌感染的增效作用研究 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202310043
    [3] 丁华敏, 郭羽晨, 秦春霞, 宋志兵, 孙莉莉.  消风止痒颗粒通过降低白三烯水平对小鼠特应性皮炎急性瘙痒的治疗作用研究 . 药学实践与服务, 2024, 42(5): 211-216. doi: 10.12206/j.issn.2097-2024.202306031
    [4] 王晓飞, 张颖, 顾佳钰, 胡馨儿, 张海, 曹岩.  表面等离子共振传感器的识别元件在医药领域中的研究应用进展 . 药学实践与服务, 2024, 42(): 1-9. doi: 10.12206/j.issn.2097-2024.202309014
    [5] 李清, 郭宜银, 陈颖, 瞿发林, 董文燊, 戈煜.  夜宁胶囊对小鼠镇静催眠作用及其机制的研究 . 药学实践与服务, 2024, 42(8): 346-349. doi: 10.12206/j.issn.2097-2024.202211047
    [6] 陈静, 何瑞华, 翁月, 徐熠, 刘静, 黄瑾.  基于网络药理学和分子对接技术探究定清片活性成分治疗白血病的作用机制 . 药学实践与服务, 2024, 42(11): 1-8. doi: 10.12206/j.issn.2097-2024.202401073
    [7] 张成中, 朱雪艳, 卜其涛, 王宏瑞, 黄宝康.  基于网络药理学与分子对接预测鸡骨草特征图谱研究 . 药学实践与服务, 2024, 42(8): 350-358. doi: 10.12206/j.issn.2097-2024.202303048
    [8] 张艺昕, 关欣怡, 王博宁, 闻俊, 洪战英.  二氢吡啶类钙离子拮抗药物手性分析及其立体选择性药动学研究进展 . 药学实践与服务, 2024, 42(8): 319-324. doi: 10.12206/j.issn.2097-2024.202308062
    [9] 岳春华, 贲永光, 王海桥.  基于NLRP1炎症小体探讨百合知母汤抗抑郁的作用机制 . 药学实践与服务, 2024, 42(8): 325-333. doi: 10.12206/j.issn.2097-2024.202401033
    [10] 钱淑雨, 李铁军.  耐碳青霉烯类肠杆菌耐药机制的研究进展 . 药学实践与服务, 2024, 42(10): 419-425. doi: 10.12206/j.issn.2097-2024.202405005
    [11] 刘汝雄, 杨万镇, 涂杰, 盛春泉.  铁死亡调控蛋白GPX4的小分子抑制剂研究进展 . 药学实践与服务, 2024, 42(9): 375-378. doi: 10.12206/j.issn.2097-2024.202312075
    [12] 顾佳钰, 胡馨儿, 王晓飞, 张颖, 张海, 曹岩.  侧流免疫层析定量检测方法的研究进展 . 药学实践与服务, 2024, 42(7): 273-277, 284. doi: 10.12206/j.issn.2097-2024.202307037
    [13] 马兹芬, 许维恒, 金煜翔, 薛磊.  食管癌的靶向治疗与免疫治疗研究进展 . 药学实践与服务, 2024, 42(6): 231-237. doi: 10.12206/j.issn.2097-2024.202306008
    [14] 徐飞, 陈瑾, 鲁育含, 李志勇.  肠道菌群参与糖尿病肾病的机制研究进展 . 药学实践与服务, 2024, 42(5): 181-184, 197. doi: 10.12206/j.issn.2097-2024.202312023
    [15] 杨凤艳, 张月, 陈恩贤, 缪雪蓉, 魏凯.  瑞马唑仑临床应用研究进展 . 药学实践与服务, 2024, 42(9): 365-374. doi: 10.12206/j.issn.2097-2024.202405026
    [16] 姜涛, 徐卫凡, 蒋益萍, 夏天爽, 辛海量.  巴戟天丸组方对Aβ损伤成骨细胞的作用及基于网络药理学的机制研究 . 药学实践与服务, 2024, 42(7): 285-290, 296. doi: 10.12206/j.issn.2097-2024.202305011
    [17] 景凯, 杨慈荣, 张圳, 臧艺蓓, 刘霞.  黄芪甲苷衍生物治疗慢性心力衰竭小鼠的药效评价及作用机制研究 . 药学实践与服务, 2024, 42(5): 190-197. doi: 10.12206/j.issn.2097-2024.202310004
    [18] 宋泽成, 陈林林, 鲁仁义, 刘梦肖, 王彦.  脓毒症治疗的研究进展 . 药学实践与服务, 2024, 42(11): 1-5. doi: 10.12206/j.issn.2097-2024.202405059
    [19] 张林晨, 张小琴, 张俊平.  山楂酸药理作用的研究进展 . 药学实践与服务, 2024, 42(5): 185-189. doi: 10.12206/j.issn.2097-2024.202307052
    [20] 王耀振, 徐灿, 吕顺莉, 田泾, 张东炜.  钾离子竞争性酸阻滞剂的药学特征研究进展 . 药学实践与服务, 2024, 42(7): 278-284. doi: 10.12206/j.issn.2097-2024.202306040
  • 加载中
计量
  • 文章访问数:  3221
  • HTML全文浏览量:  417
  • PDF下载量:  502
  • 被引次数: 0
出版历程
  • 收稿日期:  2011-04-12
  • 修回日期:  2011-07-13

知母皂苷及其苷元的药理作用研究进展

摘要: 知母皂苷及其苷元是临床常用中药材知母的最主要活性成分,具有广泛的生物活性和药理作用。研究表明,知母皂苷及其苷元具有防治老年痴呆症、保护脑缺血损伤、抗凝血、抗氧化、抗肿瘤、抗骨质疏松、抗炎、降血压、降血糖及降血脂等药理活性。本文对知母皂苷及其苷元的上述药理作用研究进展进行综述,为进一步开发利用提供参考。

English Abstract

蔡飞, 王维泓, 高守红, 陈万生. 知母皂苷及其苷元的药理作用研究进展[J]. 药学实践与服务, 2011, 29(5): 331-335.
引用本文: 蔡飞, 王维泓, 高守红, 陈万生. 知母皂苷及其苷元的药理作用研究进展[J]. 药学实践与服务, 2011, 29(5): 331-335.
CAI Fei, WANG Wei-hong, GAO Shou-hong, CHEN Wan-sheng. Advances in the pharmacological studies on timosaponins and their sapogenins[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 331-335.
Citation: CAI Fei, WANG Wei-hong, GAO Shou-hong, CHEN Wan-sheng. Advances in the pharmacological studies on timosaponins and their sapogenins[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 331-335.
参考文献 (46)

目录

    /

    返回文章
    返回