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心脑血管疾病是心脏血管和脑血管疾病的统称,泛指由于高脂血症、血液黏稠、动脉粥样硬化、高血压等所导致的心脏、大脑及全身组织发生的缺血性或出血性疾病。心脑血管疾病是一种严重威胁人类健康的常见病,具有高患病率、高致残率和高死亡率的特点。这种疾病也对我国人民的健康和医疗卫生事业的发展带来了巨大的挑战。而在心脑血管疾病中,又以缺血性心脏病和缺血性脑卒中最为常见[1-3]。
黄酮类化合物(flavonoids)是一类广泛存在于自然界植物中的次生代谢产物。是一种以黄酮(2-苯基色原酮)为母核而衍生的一类黄色色素,其中包括黄酮的同分异构体及其氢化和还原产物[4]。它在植物的生长、发育、开花、结果以及抗菌防病等方面起着重要的作用。本文将对目前黄酮类化合物抗心脑血管疾病的作用研究进展作一综述。
Research progress of the effect of flavonoids on cardiovascular and cerebrovascular ischemic diseases
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摘要: 黄酮类化合物是一种广泛存在于传统中药中的次生代谢产物,拥有许多生物活性和药理作用。近年来,研究发现黄酮类化合物可以通过多种途径在缺血性脑卒中和缺血性心脏病的治疗中发挥有效的保护作用,同时对于其保护作用的机制也有了较为详细系统的阐释。比如黄酮类化合物可以在抗氧化、抑制炎症反应、细胞凋亡和自噬等病理生理机制中发挥有效作用。本文通过查阅国内外的相关文献,对黄酮类化合物抗心脑血管缺血性疾病的保护作用及其机制进行综述。旨在为抗心脑血管疾病药物的研究开发提供参考。Abstract: Flavonoids are secondary metabolites that widely existing in traditional Chinese medicine. They have many biological activities and pharmacological effects. In recent years, studies have found that flavonoids can play an effective protective role in the treatments of ischemic stroke and ischemic heart disease through various ways. The mechanisms of their protective effects have been systematically explained in detail. For example, flavonoids can affect pathophysiological mechanisms such as antioxidant, inhibition of inflammatory response, apoptosis and autophagy pathway. This paper reviews the protective effect and mechanisms of the treatments of flavonoids on cardiovascular and cerebrovascular ischemic diseases by referring to relevant literatures. The purpose is to provide reference for future research and development of drugs for the treatments of cardiovascular and cerebrovascular diseases.
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Key words:
- flavonoids /
- ischemic heart disease /
- ischemic stroke /
- protective effect /
- mechanism of action
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