止消通脉宁颗粒对糖尿病肾病证候的作用机制研究
Study on mechanism of action of Zhixiao Tongmaining granules on diabetic nephropathy
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摘要: 目的:研究止消通脉宁颗粒对糖尿病肾病的治疗作用。方法:用血液流变仪检测血液瘀滞度,观察止消通脉宁颗粒的活血化瘀作用。通过灌胃给予甲状腺素3 mg,利血平(0.01 mg/10 g)来制造小鼠阴虚模型并观察止消通脉宁颗粒对小鼠体重及耐力试验的影响。限制小鼠进食1周,制造气虚模型并观察止消通脉宁颗粒对小鼠体重和外周血中T淋巴细胞百分数的影响。结果:与模型组相比,止消通脉宁颗粒能明显改善大鼠的血液的瘀滞状态,延长小鼠耐力实验存活时间,升高大鼠体重、胸腺指数、脾脏指数。结论:止消通脉宁颗粒能降低血瘀大鼠全血比粘度,有效改善血液瘀滞状态;对阴虚小鼠状态有较好的改善作用;同时对气虚小鼠也有一定治疗作用。Abstract: Objective :To investigate the effects of Zhixiao Tongmaining granules on diabetic nephropathy. Methods : The blood stasis of rats were detected by blood rheometer to investigate the effects of activating blood circulation to dissipate blood stasis of Zhixiao Tongmaining granules.The yin deficiency model of mice were made by intragastric administration of thyroxin(3 mg) and reserpine(0.01 mg/10 g) for investigating the effects of body weight of rats and endurance test.Mice qi-deficiency model of were made by limiting mice food-intake for one week for investigating the effects of body weight of rats and lymphocyte percentage of peripheral blood. Results :Compared with model group,Zhixiao Tongmaining granules can improve condition of blood stasis on rats,extend survival time of mice on staying power experiment,increase body weight of rats,index number of thymus,index number of spleen. Conclusion :Zhixiao Tongmaining granules can decrease whole blood specific viscosity of blood stasis rats,effectively improve condition of blood stasis.Zhixiao Tongmaining granules have the effect of improving the condition of yin deficency mice,also have part of therapeutic action on mice with qi deficiency.
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