2021 Vol. 39, No. 1
Display Method:
2021, 39(1): 1-3, 8.
doi: 10.12206/j.issn.1006-0111.202004038
Abstract:
Objective To review the research progress in new formulations of norcantharidin. Methods The foreign and domestic literature search in the new formulations of norcantharidin was conducted. The research and development of norcantharidin formulat...
2021, 39(1): 4-8.
doi: 10.12206/j.issn.1006-0111.202006024
Abstract:
Signal transducer and activator of transcription 3 (STAT3) is a signal transcription protein that exists in the cytoplasm. The abnormal activation of STAT3 is closely related to cell proliferation, differentiation, and canceration. It has abnormal ex...
Signal transducer and activator of transcription 3 (STAT3) is a signal transcription protein that exists in the cytoplasm. The abnormal activation of STAT3 is closely related to cell proliferation, differentiation, and canceration. It has abnormal ex...
2021, 39(1): 9-12, 43.
doi: 10.12206/j.issn.1006-0111.202004030
Abstract:
Baicalein (BE) is an active ingredient derived from the root of Scutellaria baicalensis Georgi. It is a polyhydroxyflavonoid in structure and has many biological activities. Among them, the antitumor effects of baicalein have received widespread atte...
Baicalein (BE) is an active ingredient derived from the root of Scutellaria baicalensis Georgi. It is a polyhydroxyflavonoid in structure and has many biological activities. Among them, the antitumor effects of baicalein have received widespread atte...
2021, 39(1): 13-16, 22.
doi: 10.12206/j.issn.1006-0111.202006077
Abstract:
Objective To investigate the effects of Nicotinamide mononucleotide (NMN) on ulcerative colitis induced by dextran sulfate sodium (DSS) in mice. Methods D SS-induced ulcerative colitis mice were used to evaluate the effects of NMN. After NMN admini...
Mechanism of Sinomenii caulis in the treatment of rheumatoid arthritis based on network pharmacology
2021, 39(1): 17-22.
doi: 10.12206/j.issn.1006-0111.202004117
Abstract:
Objective To explore the molecular targets and associated potential pathways of Sinomenii caulis in the treatment of rheumatoid arthritis (RA) based on network pharmacology. Methods T he constituents of Sinomenii caulis were searched by Traditional...
2021, 39(1): 23-28.
doi: 10.12206/j.issn.1006-0111.202007128
Abstract:
Objective To establish an online quantitative analysis model for moisture content assay of hydroxychloroquine sulfate particles by near infrared (NIR) spectroscopy. Methods T he NIR spectra were collected in real time when the material particles we...
2021, 39(1): 29-34.
doi: 10.12206/j.issn.1006-0111.202008109
Abstract:
Objective Colon-targeting capsules based on gastric pellets and enteric pellets were prepared from Baizhu Huanglian prescription. The formulation composition and preparation process were optimized and the in-vitro release characteristics were invest...
2021, 39(1): 35-37, 57.
doi: 10.12206/j.issn.1006-0111.202007022
Abstract:
Objective To search for novel potent 3-ester derivatives of arenobufagin and test their antitumor activities in vitro. Methods T arget compounds were synthesized by esterification of arenobufagin with acids. CellTiter method was used to assay the i...
2021, 39(1): 38-43.
doi: 10.12206/j.issn.1006-0111.202003191
Abstract:
Objective To study the synergistic effects of aspirin and atorvastatin on cell proliferation of non-small cell lung cancer cell A549 and NCI-H460 and the mechanism of these actions. Methods The proliferation of A549 and NCI-H460 cells t...
2021, 39(1): 44-48, 76.
doi: 10.12206/j.issn.1006-0111.202005030
Abstract:
Objective To prepare an ultra-porous hydrogel capable of controlled release and investigate the drug loading, releasing, administration route and efficacy with insulin as a model drug. Methods T he polymer interpenetrating network method was used t...
2021, 39(1): 49-52.
doi: 10.12206/j.issn.1006-0111.202006043
Abstract:
Objective To study the pharmacokinetic differences of pure salidroside and Kunfukang pills in rats and explore the pharmacokinetic changes of salidroside as a pure form or in the mixture. Methods T he rats were divided into two groups. One group re...
2021, 39(1): 53-57.
doi: 10.12206/j.issn.1006-0111.202005038
Abstract:
Objective To establish an assay method for monohydroxy carbamazepine, the active metabolite of oxcarbazepine, in human plasma. Methods O rnidazole was used as the internal standard. Plasma samples were processed with methanol and analyzed by HPLC. ...
2021, 39(1): 58-61, 72.
doi: 10.12206/j.issn.1006-0111.202008062
Abstract:
Objective To screen and identify the penetration enhancer in pharmacy prepared compound terbinafine ointment. Methods I n vitro percutaneous penetration test was conducted with vertical Franz diffusion pool. The SD rat's abdomen skin was used for p...
2021, 39(1): 62-67, 96.
doi: 10.12206/j.issn.1006-0111.202012001
Abstract:
Objective To develop a HPLC-MS/MS method for the absolute bioavailability study of salidroside in Beagle dogs. Methods G astrodin was used as internal standard. Plasma samples were treated by protein precipitation and separated by Symmetry RP18 col...
2021, 39(1): 68-72.
doi: 10.12206/j.issn.1006-0111.202003189
Abstract:
Objective To improve the quality control of Dilong Shenmai oral liquid. Methods TLC was used for the qualitative identification of Astragali Radix, Ophiopogonis Radix and Schisandrae Chinensis Fructus in Dilong Shenmai oral liquid. HPLC was use...
2021, 39(1): 73-76.
doi: 10.12206/j.issn.1006-0111.202003085
Abstract:
Objective To establish a UPLC-MS/MS method for the determination of dexmedetomidine in human plasma and investigate the effect of obstructive jaundice on pharmacokinetics of dexmedetomidine in vivo. Methods S amples were obtained by liquid-liquid e...
2021, 39(1): 77-81.
doi: 10.12206/j.issn.1006-0111.202005041
Abstract:
Objective To screen the macroporous adsorption resin suitable for the separation and purification of total polyphenols from purple tea and establish the purification process parameters to prepare high-purity total polyphenols from purple tea. Metho...
2021, 39(1): 82-85, 93.
doi: 10.12206/j.issn.1006-0111.202003107
Abstract:
Objective To study the clinical effects of Yinlian Qufeng decoction in the treatment of chronic urticaria (CU) and the effects on the changes of serum IgE and T cell subsets (CD4+, CD8+). Methods 9 6 patients were randomly divided into two groups, ...
2021, 39(1): 86-89.
doi: 10.12206/j.issn.1006-0111.202004025
Abstract:
Objective To explore the treatment of pancytopenia and liver injury induced by methimazole and provide medication therapy reference for clinical pharmacists in clinical practice. Methods T he clinical pharmacists provided clinical interventions by ...
2021, 39(1): 90-93.
doi: 10.12206/j.issn.1006-0111.202004087
Abstract:
Objective To analyze the characteristics and trends of adverse drug reactions (ADR) induced by anti-infective drugs in Shanghai Prison General Hospital and provide a guideline of rational drug use and pharmacovigilance for detainees. Methods T he a...
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